Often, the emergence of unified and seamless integration of digital images within contemporary radiology workflow models is held as the exemplar by which any possible future states of an all-digital workflow model in pathology should be compared. Indeed, there is strong evidence to suggest that pathology will ultimately transform into what could be properly termed as a ‘digital diagnostic modality’, but it is important to distinguish between the prior transformative process within radiology, with its own set of operational challenges (elimination of film, modality workflow management, Digital Imaging and Communications in Medicine (DICOM) harmonization, antitrust, and proprietary file format issues, to name a few), and those challenges that now face pathology, with there being only partial overlap.