Adrenogenital syndrome caused by an androgen-producing adrenocortical tumor.

We describe here a typical case of virilizing adrenocortical tumor. A 23-year-old Japanese woman had her male-like musculature, hirsutism, the absence of breast development and marked clitoromegaly. Adrenal androgens were remarkably elevated, with plasma dehydroepiandrosterone sulfate 2,752 micrograms/dl, plasma testosterone 250 ng/dl and urinary 17-ketosteroids 203.4 mg/day. A well-encapsulated tumor approximately 7 cm in diameter was detected in the left adrenal gland by computed tomography, magnetic resonance imaging and arteriography. The tumor was surgically resected and histologically diagnosed as a benign adrenocortical adenoma. The elevated adrenal androgens returned to normal postoperatively with amelioration of her masculinized clinical features.

[1]  Y. Homma,et al.  A survey on incidental adrenal tumors in Japan. , 1992, The Journal of urology.

[2]  D. Aron,et al.  Hormonal evaluation of the patient with an incidentally discovered adrenal mass. , 1990, The New England journal of medicine.

[3]  G. Mufti,et al.  An unusual case of adrenal cortical carcinoma. , 1990, Postgraduate medical journal.

[4]  E. Okajima,et al.  [A case of infantile virilizing adrenocortical tumor]. , 1989, Hinyokika kiyo. Acta urologica Japonica.

[5]  R. Gonda,et al.  Adrenal cortical carcinoma with hepatic metastasis: preoperative radiological evaluation. , 1989, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[6]  E. Fishman,et al.  Primary adrenocortical carcinoma: CT evaluation with clinical correlation. , 1987, AJR. American journal of roentgenology.

[7]  A. Megibow,et al.  Non-functioning adrenal adenomas discovered incidentally on computed tomography. , 1983, Radiology.

[8]  P M Copeland,et al.  The incidentally discovered adrenal mass. , 1983, Annals of surgery.

[9]  R. Halvorsen,et al.  CT Appearance of Adrenal Cortical Carcinoma , 1982, Journal of computer assisted tomography.

[10]  R. Levitt,et al.  Nonfunctioning adrenal masses: incidental discovery on computed tomography. , 1982, AJR. American journal of roentgenology.

[11]  D. Orth,et al.  Clinical and laboratory findings and results of therapy in 58 patients with adrenocortical tumors admitted to a single medical center (1951 to 1978). , 1981, The American journal of medicine.

[12]  E. Elias,et al.  Natural history of adrenal cortical carcinoma: A clinicopathologic study of 42 patients , 1981, Cancer.

[13]  D. Fukushima,et al.  STEROID PRODUCTION IN "NONFUNCTIONING" ADRENAL CORTICAL TUMOR. , 1963, The Journal of clinical endocrinology and metabolism.

[14]  G. Ross,et al.  CLINICAL AND PATHOPHYSIOLOGIC ASPECTS OF ADRENOCORTICAL CARCINOMA. , 1963, The American journal of medicine.

[15]  J. Legrand,et al.  Hypoaldosteronism accompanied by normal or elevated mineralocorticosteroid pathway steroid: a marker of adrenal carcinoma. , 1993, The Journal of clinical endocrinology and metabolism.

[16]  T. Ichikawa,et al.  [Statistical review of adrenal cortical carcinoma]. , 1993, Nihon rinsho. Japanese journal of clinical medicine.

[17]  David A. Turner,et al.  Magnetic resonance imaging of adrenal cortical carcinoma , 1989, Urologic radiology.

[18]  E. Schuller,et al.  [The adrenogenital syndrome]. , 1958, Acta endocrinologica.