Manipulation Using Microrobot Driven by Optothermally Generated Surface Bubble

A manipulation technique based on optothermally generated surface bubbles is proposed in this paper. The manipulation and assembly of microstructures are completed by using bubbles. In addition, the hydrogel microstructures are also used as microrobots driven by the bubble to operate and pattern the microspheres. Considering that many materials and lasers with different wavelength have been used for generating bubbles by optothermal effects, absorptivity and transmissivity are used as indicators of selections. Besides, the size of the bubble can be controlled by the frequency and time of the laser. This technique is supposed to be applied for manipulation of cells, microparticles and microstructures.

[1]  Wenqi Hu,et al.  An opto-thermocapillary cell micromanipulator. , 2013, Lab on a chip.

[2]  Qihui Fan,et al.  Laser-induced microbubble poration of localized single cells. , 2014, Lab on a chip.

[3]  Lianqing Liu,et al.  High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues. , 2017, Small.

[4]  Daniel Ahmed,et al.  A millisecond micromixer via single-bubble-based acoustic streaming. , 2009, Lab on a chip.

[5]  Wenqi Hu,et al.  Micro-assembly using optically controlled bubble microrobots , 2011 .

[6]  Hsan-Yin Hsu,et al.  Optically actuated thermocapillary movement of gas bubbles on an absorbing substrate. , 2007, Applied physics letters.

[7]  S. Gedney.  An anisotropic perfectly matched layer-absorbing medium for the truncation of FDTD lattices , 1996 .

[8]  Lianqing Liu,et al.  A Micromanipulator and Transporter Based on Vibrating Bubbles in an Open Chip Environment , 2017, Micromachines.

[9]  Mengxi Wu,et al.  Mixing high-viscosity fluids via acoustically driven bubbles , 2017, Journal of micromechanics and microengineering : structures, devices, and systems.

[10]  Yuliang Xie,et al.  An optothermally generated surface bubble and its applications. , 2017, Nanoscale.

[11]  Axel Günther,et al.  Bubble gate for in-plane flow control. , 2011, Lab on a chip.

[12]  Wenqi Hu,et al.  Efficient single-cell poration by microsecond laser pulses. , 2015, Lab on a chip.

[13]  Sang Kug Chung,et al.  On-chip manipulation of objects using mobile oscillating bubbles , 2008 .

[14]  Wenqi Hu,et al.  Hydrogel microrobots actuated by optically generated vapour bubbles. , 2012, Lab on a chip.

[15]  Zhidong Wang,et al.  Cooperative Micromanipulation Using the Independent Actuation of Fifty Microrobots in Parallel , 2017, Scientific Reports.

[16]  Claus-Dieter Ohl,et al.  Laser-induced cavitation based micropump. , 2008, Lab on a chip.

[17]  Sang Kug Chung,et al.  On-chip micromanipulation by AC-EWOD driven twin bubbles , 2013 .

[18]  Lianqing Liu,et al.  Particle manipulation via opto-thermally generated bubbles in open chip environment , 2016, 2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO).

[19]  Steven G. Johnson,et al.  Meep: A flexible free-software package for electromagnetic simulations by the FDTD method , 2010, Comput. Phys. Commun..

[20]  Kai Zhang,et al.  Laser-induced thermal bubbles for microfluidic applications. , 2011, Lab on a chip.

[21]  Yuechao Wang,et al.  Mask-free fabrication of a versatile microwell chip for multidimensional cellular analysis and drug screening. , 2017, Lab on a chip.

[22]  Xueliang Li,et al.  A bubble-assisted electroosmotic micropump for a delivery of a droplet in a microfluidic channel combined with a light-addressable potentiometric sensor , 2017 .

[23]  Lei Wang,et al.  A microfluidic device with passive air-bubble valves for real-time measurement of dose-dependent drug cytotoxicity through impedance sensing. , 2012, Biosensors & bioelectronics.

[24]  Khashayar Khoshmanesh,et al.  A multi-functional bubble-based microfluidic system , 2015, Scientific Reports.

[25]  Shikuan Yang,et al.  Theory and experiment on particle trapping and manipulation via optothermally generated bubbles. , 2014, Lab on a chip.