Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

The authors describe a new approach to studying cellular lipid profiles and propose a compensatory mechanism that may help maintain the normal membrane function of adipocytes in the context of obesity.

[1]  Ronald J A Wanders,et al.  Functions and biosynthesis of plasmalogens in health and disease. , 2004, Biochimica et biophysica acta.

[2]  A. Rissanen,et al.  ACQUIRED OBESITY INCREASES CD68 AND TNF-α AND DECREASES ADIPONECTIN GENE EXPRESSION IN ADIPOSE TISSUE. A study in monozygotic twins. , 2006 .

[3]  Tom Britton,et al.  Dynamics of fat cell turnover in humans , 2008, Nature.

[4]  A. Rissanen,et al.  Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity. , 2004, Twin research : the official journal of the International Society for Twin Studies.

[5]  R. Zoeller,et al.  Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. , 1999, Journal of lipid research.

[6]  W. Lieberthal,et al.  Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether. , 1999, The Biochemical journal.

[7]  F. Snyder,et al.  The retention of arachidonic acid in ethanolamine plasmalogens of rat testes during essential fatty acid deficiency. , 1973, Biochimica et biophysica acta.

[8]  Xianlin Han,et al.  Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. , 2003, Journal of lipid research.

[9]  Marko Sysi-Aho,et al.  Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin Study , 2007, PloS one.

[10]  A. Fonteh,et al.  Rapid remodeling of arachidonate from phosphatidylcholine to phosphatidylethanolamine pools during mast cell activation. , 1992, Journal of immunology.

[11]  A. Vidal-Puig,et al.  Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. , 2010, Biochimica et biophysica acta.

[12]  Charles N. Serhan,et al.  Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators , 2008, Nature Reviews Immunology.

[13]  A. Rissanen,et al.  Improving the Accuracy of Self-Reports on Diet and Physical Exercise: The Co-Twin Control Method , 2009, Twin Research and Human Genetics.

[14]  Adrian E. Raftery,et al.  Model-based Methods of Classification: Using the mclust Software in Chemometrics , 2007 .

[15]  M. Orešič,et al.  Role of cardiolipins in the inner mitochondrial membrane: insight gained through atom-scale simulations. , 2009, The journal of physical chemistry. B.

[16]  T. Sørensen,et al.  Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? , 2010, Biochimica et biophysica acta.

[17]  N. Abumrad,et al.  Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. , 2002, Annual review of nutrition.

[18]  A. Häkkinen,et al.  Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. , 2005, American journal of physiology. Endocrinology and metabolism.

[19]  A. Holt,et al.  Lateral diffusion of membrane proteins. , 2009, Journal of the American Chemical Society.

[20]  A. Häkkinen,et al.  Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins , 2006, Obesity.

[21]  M. Zeidel,et al.  The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons , 1995, The Journal of general physiology.

[22]  Ilpo Vattulainen,et al.  Assessing the Nature of Lipid Raft Membranes , 2007, PLoS Comput. Biol..

[23]  Leena Peltonen,et al.  Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity , 2008, PLoS medicine.

[24]  R. Murphy,et al.  Susceptibility of plasmenyl glycerophosphoethanolamine lipids containing arachidonate to oxidative degradation. , 1999, Free radical biology & medicine.

[25]  K. Gawrisch,et al.  The structure of polyunsaturated lipid bilayers important for rhodopsin function: a neutron diffraction study. , 2006, Biophysical journal.

[26]  S. Gogg,et al.  Thiazolidinediones (PPARγ agonists) but not PPAR α agonists increase IRS‐2 gene expression in 3T3‐L1 and human adipocytes 1 , 2001 .

[27]  Ilpo Vattulainen,et al.  Lessons of slicing membranes: interplay of packing, free area, and lateral diffusion in phospholipid/cholesterol bilayers. , 2004, Biophysical journal.

[28]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[29]  Carsten Kutzner,et al.  GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. , 2008, Journal of chemical theory and computation.

[30]  B. Kowalski,et al.  Partial least-squares regression: a tutorial , 1986 .

[31]  A. Vidal-Puig,et al.  It's Not How Fat You Are, It's What You Do with It That Counts , 2008, PLoS biology.

[32]  Matej Oresic,et al.  MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data , 2006, Bioinform..

[33]  I. Vattulainen,et al.  Collective Dynamics in Lipid Membranes: From Pore Formation to Flip-Flops , 2009 .

[34]  D. Huster,et al.  Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. , 1998, Biochemistry.

[35]  Laxman Yetukuri,et al.  PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism , 2007, PLoS genetics.

[36]  Robert Castelo,et al.  Reverse Engineering Molecular Regulatory Networks from Microarray Data with qp-Graphs , 2009, J. Comput. Biol..

[37]  M. Orešič,et al.  Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra‐abdominal Adipose Tissue, and Serum , 2010, Obesity.

[38]  I. Vattulainen,et al.  Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles. , 2007, The journal of physical chemistry. B.

[39]  A. Rissanen,et al.  Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. , 2004, The Journal of clinical endocrinology and metabolism.

[40]  G. Reaven.  Role of Insulin Resistance in Human Disease , 1988, Diabetes.

[41]  R. Murphy.  Free-radical-induced oxidation of arachidonoyl plasmalogen phospholipids: antioxidant mechanism and precursor pathway for bioactive eicosanoids. , 2001, Chemical research in toxicology.

[42]  Jacques van Helden,et al.  Network Analysis Tools: from biological networks to clusters and pathways , 2008, Nature Protocols.

[43]  Matej Oresic,et al.  Lipidomics: a new window to biomedical frontiers. , 2008, Trends in biotechnology.

[44]  Matej Oresic,et al.  Systems biology strategy to study lipotoxicity and the metabolic syndrome. , 2010, Biochimica et biophysica acta.

[45]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[46]  E. Goetzl,et al.  Mediation of leukocyte components of inflammatory reactions by lipoxygenase products of arachidonic acid. , 1982, Advances in prostaglandin, thromboxane, and leukotriene research.

[47]  Matej Oresic,et al.  Processing methods for differential analysis of LC/MS profile data , 2005, BMC Bioinformatics.

[48]  G. Shulman,et al.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.

[49]  Matej Oresic,et al.  Application of lipidomics and metabolomics to the study of adipose tissue. , 2008, Methods in molecular biology.

[50]  G. Reaven.  Banting lecture 1988. Role of insulin resistance in human disease. , 1988, Diabetes.

[51]  Michael L. Creech,et al.  Integration of biological networks and gene expression data using Cytoscape , 2007, Nature Protocols.

[52]  Jaakko Kaprio,et al.  Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families. , 2002, Twin research : the official journal of the International Society for Twin Studies.

[53]  Pascal G. P. Martin,et al.  The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. , 2010, Progress in lipid research.

[54]  A. Rissanen,et al.  Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance , 2004, Diabetologia.

[55]  A. Rissanen,et al.  Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins. , 2006, The Journal of clinical endocrinology and metabolism.

[56]  C. Raetz,et al.  Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation. , 1988, The Journal of biological chemistry.

[57]  D. Vance,et al.  Biochemistry.of.Lipids,.Lipoproteins.and.Membranes,.4th.edition , 2002 .

[58]  R. Murphy,et al.  Analysis of stable oxidized molecular species of glycerophospholipids following treatment of red blood cell ghosts with t-butylhydroperoxide. , 1998, Analytical biochemistry.

[59]  John D. Storey.  A direct approach to false discovery rates , 2002 .