Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression.

[1]  Man Zhao,et al.  HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression. , 2023, Cancer research.

[2]  Jia Li,et al.  Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a-induced liver cell damage. , 2022, Toxicology in vitro : an international journal published in association with BIBRA.

[3]  Weiwei Tang,et al.  Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing , 2022, Redox biology.

[4]  Xinrui Zhao,et al.  SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma , 2022, Cell Death & Differentiation.

[5]  Qi Wu,et al.  Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[6]  B. Stockwell.  Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications , 2022, Cell.

[7]  Lin Sun,et al.  Saikosaponin-A Exhibits Antipancreatic Cancer Activity by Targeting the EGFR/PI3K/Akt Pathway. , 2022, Current pharmaceutical biotechnology.

[8]  J. R. Peterson,et al.  The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells , 2022, Cell death discovery.

[9]  H. Zhang,et al.  Saikosaponin A inhibits growth of human bladder carcinoma T24 and 5637 cells both in vitro and in vivo. , 2022, Biological & pharmaceutical bulletin.

[10]  M. Ocker,et al.  Ferroptosis in Hepatocellular Carcinoma: Mechanisms, Drug Targets and Approaches to Clinical Translation , 2022, Cancers.

[11]  T. Lan,et al.  Limonin, an AMPK Activator, Inhibits Hepatic Lipid Accumulation in High Fat Diet Fed Mice , 2022, Frontiers in Pharmacology.

[12]  Xiaopeng Li,et al.  The multifaceted role of ferroptosis in liver disease , 2022, Cell Death & Differentiation.

[13]  Q. Lu,et al.  Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway , 2021, Frontiers in Pharmacology.

[14]  Lin Dong,et al.  A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway. , 2021, Journal of ethnopharmacology.

[15]  Jikun Du,et al.  Saikosaponin-A induces apoptosis of cervical cancer through mitochondria- and endoplasmic reticulum stress-dependent pathway in vitro and in vivo: involvement of PI3K/AKT signaling pathway , 2021, Cell cycle.

[16]  Juan Wang,et al.  Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells , 2021, International journal of biological sciences.

[17]  Shan Lu,et al.  ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron , 2021, Acta Pharmacologica Sinica.

[18]  Chunxiao Wang,et al.  Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling , 2021, Cellular & molecular biology letters.

[19]  T. Lan,et al.  Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization , 2021, Frontiers in Physiology.

[20]  Yihan Yao,et al.  Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management , 2021, Frontiers in Oncology.

[21]  Si-wei Wang,et al.  Hesperetin promotes DOT1L degradation and reduces histone H3K79 methylation to inhibit gastric cancer metastasis. , 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[22]  G. Kroemer,et al.  Broadening horizons: the role of ferroptosis in cancer , 2021, Nature Reviews Clinical Oncology.

[23]  L. Zhuang,et al.  Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy , 2020, Protein & Cell.

[24]  Lijuan Li,et al.  Role of ATF3 as a prognostic biomarker and correlation of ATF3 expression with macrophage infiltration in hepatocellular carcinoma , 2020, BMC Medical Genomics.

[25]  Ching-Feng Cheng,et al.  Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer , 2020, Frontiers in Endocrinology.

[26]  D. Tang,et al.  Transcription factors in ferroptotic cell death , 2020, Cancer Gene Therapy.

[27]  A. Villanueva,et al.  Tumour evolution in hepatocellular carcinoma , 2019, Nature Reviews Gastroenterology & Hepatology.

[28]  T. Du,et al.  ATF3 promotes erastin-induced ferroptosis by suppressing system Xc– , 2019, Cell Death & Differentiation.

[29]  A. Villanueva.  Hepatocellular Carcinoma. , 2019, The New England journal of medicine.

[30]  Ming Yao,et al.  ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression , 2018, Journal of Experimental & Clinical Cancer Research.

[31]  B. Kim,et al.  Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells , 2017, Oncotarget.

[32]  R. Teschke,et al.  Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study , 2017, World journal of hepatology.

[33]  B. Stockwell,et al.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.

[34]  Young Ho Suh,et al.  Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis. , 2017, Journal of hepatology.

[35]  Jie Min,et al.  Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines , 2017, Cancer Cell International.

[36]  M. Rauh,et al.  ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner , 2017, Oncogene.

[37]  G. Danan,et al.  RUCAM in Drug and Herb Induced Liver Injury: The Update , 2015, International journal of molecular sciences.

[38]  Z. Ronai,et al.  UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. , 2015, Trends in biochemical sciences.

[39]  Matthew E. Welsch,et al.  Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis , 2014, eLife.

[40]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[41]  J. Ao,et al.  ATF3 activates Stat3 phosphorylation through inhibition of p53 expression in skin cancer cells. , 2013, Asian Pacific journal of cancer prevention : APJCP.

[42]  John Calvin Reed,et al.  ER stress-induced cell death mechanisms. , 2013, Biochimica et biophysica acta.

[43]  R. Kaufman,et al.  ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death , 2013, Nature Cell Biology.

[44]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[45]  Stephen A. Ramsey,et al.  ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells , 2010, Journal of Cell Science.

[46]  Arnd Hengstermann,et al.  Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival. , 2008, Free radical biology & medicine.

[47]  Yoon-Koo Kang,et al.  Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. , 2009, The Lancet. Oncology.