Raf-1 and protein kinase B regulate cell survival through the activation of NF-kappaB in hepatitis B virus X-expressing cells.

[1]  S. Kaneko,et al.  Molecular functions and biological roles of hepatitis B virus x protein , 2006, Cancer science.

[2]  P. Dent,et al.  Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role. , 2006, Human gene therapy.

[3]  H. Kiyokawa,et al.  Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. , 2006, Diabetes.

[4]  H. Will,et al.  Induction of anti-proliferative mechanisms in hepatitis B virus producing cells. , 2005, Journal of hepatology.

[5]  S. Jeon,et al.  Both ERK and Wnt/β-catenin pathways are involved in Wnt3a-induced proliferation , 2005, Journal of Cell Science.

[6]  W. Roesler,et al.  Effect of overexpression and nuclear translocation of constitutively active PKB‐α on cellular survival and proliferation in HepG2 cells , 2004, Journal of cellular biochemistry.

[7]  T. Mohanakumar,et al.  Pre‐exposure to sub‐saturating concentrations of HLA class I antibodies confers resistance to endothelial cells against antibody complement‐mediated lysis by regulating Bad through the phosphatidylinositol 3‐kinase/Akt pathway , 2004, European journal of immunology.

[8]  S. Curley,et al.  Role of Rel/NF‐κB transcription factors in apoptosis of human hepatocellular carcinoma cells , 2002, Cancer.

[9]  Sun Park,et al.  NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival. , 2002, Cancer letters.

[10]  B. Slagle,et al.  Stimulation of Cellular Proliferation by Hepatitis B Virus X Protein , 2002, Disease markers.

[11]  S. Murakami.  Hepatitis B virus X protein: a multifunctional viral regulator , 2001, Journal of Gastroenterology.

[12]  Y. Yun,et al.  Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers. , 2001, Biochemical and biophysical research communications.

[13]  S. Thorgeirsson,et al.  Roles of Akt/PKB and IKK complex in constitutive induction of NF‐κB in hepatocellular carcinomas of transforming growth factor α/c‐myc transgenic mice , 2001 .

[14]  P. Arbuthnot,et al.  A cellular gene up‐regulated by hepatitis B virus–encoded X antigen promotes hepatocellular growth and survival , 2001, Hepatology.

[15]  S. Do,et al.  The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade* , 2001, The Journal of Biological Chemistry.

[16]  J. Woodgett,et al.  X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway* , 2001, The Journal of Biological Chemistry.

[17]  S. Thorgeirsson,et al.  Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice. , 2001, Hepatology.

[18]  J. McCubrey,et al.  Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells. , 2001, Cancer detection and prevention.

[19]  J. Pan,et al.  Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. , 2001, The Journal of general virology.

[20]  L. Duan,et al.  Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-κB , 2001 .

[21]  Y. Liaw,et al.  Constitutive activation of nuclear factor κB in hepatocellular carcinoma , 2000 .

[22]  Kyoungsook Park,et al.  Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells , 2000, Oncogene.

[23]  M. Kuo,et al.  Hepatitis B Virus X Protein Inhibits Transforming Growth Factor-β-induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway* , 2000, The Journal of Biological Chemistry.

[24]  Y. I. Lee,et al.  Hepatitis B virus-X protein upregulates the expression of p21wafl/cipl and prolongs G1→S transition via a p53-independent pathway in human hepatoma cells , 2000, Oncogene.

[25]  Y. Lee,et al.  Disruption of actin cytoskeleton induces chondrogenesis of mesenchymal cells by activating protein kinase C-alpha signaling. , 2000, Biochemical and biophysical research communications.

[26]  Y. Liaw,et al.  Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. , 2000, Cancer.

[27]  M. Kuo,et al.  Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. , 2000, The Journal of biological chemistry.

[28]  T. Gilmore,et al.  Control of apoptosis by Rel/NF-κB transcription factors , 1999, Oncogene.

[29]  A. Israël,et al.  Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-κB Inhibitor IκBα , 1999, Molecular and Cellular Biology.

[30]  S. Murakami.  Hepatitis B Virus X Protein: Structure, Function and Biology , 1999, Intervirology.

[31]  T. Gilmore,et al.  Control of apoptosis by Rel/NF-kappaB transcription factors. , 1999, Oncogene.

[32]  A. Israël,et al.  Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. , 1999, Molecular and cellular biology.

[33]  P. Tsichlis,et al.  AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. , 1999, Annual review of biochemistry.

[34]  W. Zong,et al.  Rel blocks both anti-Fas- and TNFα-induced apoptosis and an intact Rel transactivation domain is essential for this effect , 1998, Cell Death and Differentiation.

[35]  Y. Yun,et al.  HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling* , 1998, The Journal of Biological Chemistry.

[36]  J. Troppmair,et al.  Activation of NF-κB by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade , 1998, Oncogene.

[37]  C. Rudin,et al.  Bcl-xL is phosphorylated in malignant cells following microtubule disruption. , 1998, Cancer research.

[38]  K. Kaestner,et al.  p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between Ras‐mutated and Ras‐wild‐type lesions , 1998, Hepatology.

[39]  R. Schmid,et al.  Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. , 1998, The Journal of clinical investigation.

[40]  R. Schneider,et al.  Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras , 1997, Molecular and cellular biology.

[41]  S. Roche,et al.  Src and Ras are involved in separate pathways in epithelial cell scattering , 1997, The EMBO journal.

[42]  Michael Karin,et al.  Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death , 1996, Cell.

[43]  F. Su,et al.  Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins , 1996, Journal of virology.

[44]  M. Andjelkovic,et al.  Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  G. Natoli,et al.  Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway , 1996, Journal of virology.

[46]  L. Zon,et al.  c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine (*) , 1995, The Journal of Biological Chemistry.

[47]  F. Bertrand,et al.  Insulin Activates Nuclear Factor κB in Mammalian Cells through a Raf-1-mediated Pathway (*) , 1995, The Journal of Biological Chemistry.

[48]  R. Lucito,et al.  The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. , 1995, The EMBO journal.

[49]  K. Koike.  Hepatitis B virus HBx gene and hepatocarcinogenesis. , 1995, Intervirology.

[50]  S. Krajewski,et al.  Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. , 1994, Oncogene.

[51]  J. Cleveland,et al.  v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. , 1994, Oncogene.

[52]  P. Hofschneider,et al.  Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway , 1993, Nature.

[53]  P. Hofschneider,et al.  The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C. , 1993, Research in virology.

[54]  D. Baltimore,et al.  I kappa B: a specific inhibitor of the NF-kappa B transcription factor. , 1988, Science.

[55]  R. Beasley.  Hepatitis B virus. The major etiology of hepatocellular carcinoma , 1988, Cancer.

[56]  Lu-Yu Hwang,et al.  HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS A Prospective Study of 22 707 Men in Taiwan , 1981, The Lancet.

[57]  G. M. Iverson,et al.  Expression of liver and placental alkaline phosphatases in Chang liver cells , 1977, Journal of cellular physiology.