Stimulating action of catecholamines on isolated preparations of the rat colon and human and rabbit taeniae coli

1 Adrenaline and noradrenaline induced dose related relaxations of the superfused rat colon. The relaxations were progressively transformed into contractions when β‐adrenoceptors were blocked with increasing doses of oxprenolol. 2 Since phentolamine or phenoxybenzamine inhibited the contractions induced by adrenaline or noradrenaline in the presence of oxprenolol, it is assumed that the contractions are caused by stimulation of excitatory α‐adrenoceptors. 3 Human and rabbit taeniae coli showed responses that were qualitatively similar to those observed with the rat colon.

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