Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.

[1]  E. Masliah,et al.  Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease , 2011, PloS one.

[2]  S. Love,et al.  Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia , 2010, Brain Research.

[3]  Masaki Tanaka,et al.  Extracellular neurosin degrades α-synuclein in cultured cells , 2010, Neuroscience Research.

[4]  E. Masliah,et al.  A Pathologic Cascade Leading to Synaptic Dysfunction in α-Synuclein-Induced Neurodegeneration , 2010, The Journal of Neuroscience.

[5]  D. Galasko,et al.  Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy , 2010, PloS one.

[6]  E. Masliah,et al.  Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases , 2009, The Journal of Neuroscience.

[7]  M. Blaber,et al.  Activation profiles of human kallikrein‐related peptidases by proteases of the thrombostasis axis , 2008, Protein science : a publication of the Protein Society.

[8]  Yoshihisa Watanabe,et al.  Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro , 2008, Neuroscience Letters.

[9]  Q. Hou,et al.  Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats , 2008, Brain Research.

[10]  M. Menéndez-González,et al.  Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease. , 2008, Journal of Alzheimer's disease : JAD.

[11]  E. Masliah,et al.  Novel strategies for Alzheimer's disease treatment , 2007, Expert opinion on biological therapy.

[12]  M. Blaber,et al.  The autolytic regulation of human kallikrein-related peptidase 6. , 2007, Biochemistry.

[13]  Bernardino Ghetti,et al.  Pathological Changes in Dopaminergic Nerve Cells of the Substantia Nigra and Olfactory Bulb in Mice Transgenic for Truncated Human α-Synuclein(1–120): Implications for Lewy Body Disorders , 2006, The Journal of Neuroscience.

[14]  I. Verma,et al.  Production and purification of lentiviral vectors , 2006, Nature Protocols.

[15]  S. M. Park,et al.  Proteolytic Cleavage of Extracellular Secreted α-Synuclein via Matrix Metalloproteinases* , 2005, Journal of Biological Chemistry.

[16]  Smita Patel,et al.  Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates , 2005, The Journal of Neuroscience.

[17]  S. M. Park,et al.  Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. , 2005, The Journal of biological chemistry.

[18]  Giuseppe Battaglia,et al.  Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Peter T. Lansbury,et al.  Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy , 2004, Science.

[20]  Robert Edwards,et al.  Lipid Rafts Mediate the Synaptic Localization of α-Synuclein , 2004, The Journal of Neuroscience.

[21]  Leonidas Stefanis,et al.  Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. , 2004, Science.

[22]  R. Edwards,et al.  Lipid rafts mediate the synaptic localization of alpha-synuclein. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  Tsutomu Hashikawa,et al.  Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. , 2003, Human molecular genetics.

[24]  E. Diamandis,et al.  Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. , 2003, Biochemical and biophysical research communications.

[25]  John Q. Trojanowski,et al.  Distinct cleavage patterns of normal and pathologic forms of α‐synuclein by calpain I in vitro , 2003 .

[26]  P. Axelsen,et al.  Role of α-Synuclein Carboxy-Terminus on Fibril Formation in Vitro† , 2003 .

[27]  Makoto Hashimoto,et al.  Transgenic Models of α‐Synuclein Pathology , 2003 .

[28]  J. Trojanowski,et al.  Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. , 2003, Journal of neurochemistry.

[29]  J. Trojanowski,et al.  Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. , 2003, Biochemistry.

[30]  P. Lansbury,et al.  Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. , 2002, Journal of molecular biology.

[31]  Vladimir N Uversky,et al.  Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T. , 2002, Neurotoxicology.

[32]  Makoto Hashimoto,et al.  Differential neuropathological alterations in transgenic mice expressing α‐synuclein from the platelet‐derived growth factor and Thy‐1 promoters , 2002, Journal of neuroscience research.

[33]  G. Yousef,et al.  The Spectrum of Human Kallikrein 6 (Zyme/Protease M/Neurosin) Expression in Human Tissues as Assessed by Immunohistochemistry , 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[34]  Rebecca A. Betensky,et al.  α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Nobutaka Hattori,et al.  Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease , 2001, Science.

[36]  J Q Trojanowski,et al.  A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly* , 2001, The Journal of Biological Chemistry.

[37]  E. Masliah.  The Role of Synaptic Proteins in Alzheimer's Disease , 2000, Annals of the New York Academy of Sciences.

[38]  J. Trojanowski,et al.  Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. , 2000, Science.

[39]  T Yamamoto,et al.  Localization of a novel type trypsin‐like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease , 2000, Psychiatry and clinical neurosciences.

[40]  H. Braak,et al.  Pathoanatomy of Parkinson’s disease , 2000, Journal of Neurology.

[41]  P J McLean,et al.  Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. , 2000, The Journal of biological chemistry.

[42]  K. Matsumoto,et al.  Protease M/neurosin mRNA is expressed in mature oligodendrocytes. , 1999, Brain research. Molecular brain research.

[43]  R. Anthony Crowther,et al.  Synthetic filaments assembled from C‐terminally truncated α‐synuclein , 1998 .

[44]  E. Masliah,et al.  Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment. , 1998, Laboratory investigation; a journal of technical methods and pathology.

[45]  R A Crowther,et al.  Synthetic filaments assembled from C-terminally truncated alpha-synuclein. , 1998, FEBS letters.

[46]  K. Jellinger,et al.  Neuropathology of Alzheimer's disease: a critical update. , 1998, Journal of neural transmission. Supplementum.

[47]  R. Krüger,et al.  Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. , 1998, Nature genetics.

[48]  Hitoshi Takahashi,et al.  NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease , 1997, Neuroscience Letters.

[49]  James R. Miller,et al.  Zyme, a Novel and Potentially Amyloidogenic Enzyme cDNA Isolated from Alzheimer’s Disease Brain* , 1997, The Journal of Biological Chemistry.

[50]  Robert L. Nussbaum,et al.  Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .

[51]  T. Tanaka,et al.  Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. , 1997, Biochimica et biophysica acta.

[52]  S E Ide,et al.  Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. , 1997, Science.

[53]  E. Masliah,et al.  Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. , 1996, The American journal of pathology.

[54]  K. Jellinger,et al.  Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. , 1996, Neurology.

[55]  Akihiko Iwai,et al.  The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system , 1995, Neuron.

[56]  E. Masliah,et al.  Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[57]  E. Masliah,et al.  Entorhinal neurofibrillary tangles in Alzheimer disease with Lewy bodies , 1991, Neuroscience Letters.