Alzheimer's disease: neuropathologic findings and recent advances in imaging.

[1]  Myfanwy Thomas,et al.  Alois Alzheimer: A memoir , 1987, Trends in Neurosciences.

[2]  Nick C Fox,et al.  Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images , 2001, The Lancet.

[3]  B. Yankner.  Mechanisms of Neuronal Degeneration in Alzheimer's Disease , 1996, Neuron.

[4]  D. Leibfritz,et al.  Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. , 1993, Developmental neuroscience.

[5]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[6]  K. Ishii,et al.  Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images. , 2000, Radiology.

[7]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[8]  J. Kramer,et al.  Alzheimer's Disease and Its Focal Variants , 2000, Seminars in neurology.

[9]  L. Grimaldi,et al.  Pharmacogenomics of neurodegenerative diseases. , 2001, European journal of pharmacology.

[10]  J. Mazziotta,et al.  Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J. Hoffman,et al.  FDG PET imaging in patients with pathologically verified dementia. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  D. Blacker,et al.  The genetics of Alzheimer disease: current status and future prospects. , 1998, Archives of neurology.

[13]  Mark S. Cohen,et al.  Patterns of brain activation in people at risk for Alzheimer's disease. , 2000, The New England journal of medicine.

[14]  W. Jagust,et al.  The diagnosis of dementia with single photon emission computed tomography. , 1987, Archives of neurology.

[15]  Tau Protein and the Neurofibrillary Pathology of Alzheimer's Disease , 1996, Annals of the New York Academy of Sciences.

[16]  I. Mena,et al.  SPECT in Dementia: Clinical and Pathological Correlation , 1995, Journal of the American Geriatrics Society.

[17]  I. Lemahieu,et al.  Differential Regional Cerebral Uptake of 18F-Fluoro-2-Deoxy-D-Glucose in Alzheimer’s Disease and Frontotemporal Dementia at Initial Diagnosis , 2001, European Neurology.

[18]  B D Ross,et al.  Probable Alzheimer disease: diagnosis with proton MR spectroscopy. , 1995, Radiology.

[19]  Paolo Vitali,et al.  Hippocampal perfusion in mild Alzheimer's disease , 2000, Psychiatry Research: Neuroimaging.

[20]  Thomas E. Nichols,et al.  Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease , 1996, Neurology.

[21]  A. R. Damasio,et al.  Memory‐related neural systems in Alzheimer's disease , 1990, Neurology.

[22]  P F Renshaw,et al.  Dynamic susceptibility contrast MR imaging of regional cerebral blood volume in Alzheimer disease: a promising alternative to nuclear medicine. , 1998, AJNR. American journal of neuroradiology.

[23]  E G Tangalos,et al.  Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease , 2000, Neurology.

[24]  P. Doraiswamy,et al.  Current Status of Antioxidant Therapy for Alzheimer's Disease , 1998, Journal of the American Geriatrics Society.

[25]  Charles D. Smith,et al.  Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease. , 1999, Neurology.

[26]  N. Foster,et al.  Mild cognitive impairments predict dementia in nondemented elderly patients with memory loss. , 2001, Archives of neurology.

[27]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[28]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[29]  A. Kaszniak,et al.  Clinical trial of indomethacin in Alzheimer's disease , 1993, Neurology.

[30]  J. Morris.  The Clinical Dementia Rating (CDR) , 1993, Neurology.

[31]  Claudio Soto,et al.  β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy , 1998, Nature Medicine.

[32]  C. Jack,et al.  Mild cognitive impairment and Alzheimer disease: regional diffusivity of water. , 2001, Radiology.

[33]  D M Doddrell,et al.  A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. , 1999, Magnetic resonance imaging.

[34]  H. Braak,et al.  Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories , 1997, Neurobiology of Aging.

[35]  Comparative quantitation of cerebral blood volume: SPECT versus PET. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[36]  P Pietrini,et al.  The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease. , 2001, Archives of neurology.

[37]  D T Lowenthal,et al.  1H‐MRS, MRI‐Based Hippocampal Volumetry, and 99mTc‐HMPAO‐SPECT in Normal Aging, Age‐Associated Memory Impairment, and Probable Alzheimer's Disease , 1996, Journal of the American Geriatrics Society.

[38]  P. Mcgeer,et al.  The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases , 1995, Brain Research Reviews.

[39]  R. Bronen,et al.  Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[40]  Michael W Weiner,et al.  Spectroscopic Metabolic Abnormalities in mTLE with and without MRI Evidence for Mesial Temporal Sclerosis Using Hippocampal Short‐TE MRSI , 2003, Epilepsia.

[41]  Gwenn S. Smith,et al.  The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. , 1993, AJNR. American journal of neuroradiology.

[42]  R. Floris,et al.  Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load. , 2001, AJNR. American journal of neuroradiology.

[43]  D. Selkoe,et al.  The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Protein a , 1996 .

[44]  J. Baron,et al.  The neural substrates of memory systems impairment in Alzheimer's disease. A PET study of resting brain glucose utilization. , 1998, Brain : a journal of neurology.

[45]  A. Hofman,et al.  Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. , 2001, The New England journal of medicine.

[46]  E. Sullivan,et al.  Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease , 2000, The Lancet.

[47]  T Sandor,et al.  Statistical assessment of perceptual CT scan ratings in patients with Alzheimer type dementia. , 1986, Journal of computer assisted tomography.

[48]  E F Halpern,et al.  Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18. , 1995, AJNR. American journal of neuroradiology.

[49]  P. Pietrini,et al.  Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. , 2001, Brain : a journal of neurology.

[50]  J. Voyvodic,et al.  Functional MR imaging using a visually guided saccade paradigm for comparing activation patterns in patients with probable Alzheimer's disease and in cognitively able elderly volunteers. , 2000, AJNR. American journal of neuroradiology.

[51]  K. Krishnan,et al.  Prediction of cognitive decline in early Alzheimer's disease , 1998, The Lancet.

[52]  S Minoshima,et al.  Quantitative assessment of cerebral blood flow in patients with Alzheimer's disease by SPECT. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[53]  Jeffrey L. Cummings,et al.  Cognitive and behavioral heterogeneity in Alzheimer’s disease: seeking the neurobiological basis , 2000, Neurobiology of Aging.

[54]  J. Price,et al.  Mild cognitive impairment represents early-stage Alzheimer disease. , 2001, Archives of neurology.

[55]  D. Selkoe,et al.  Translating cell biology into therapeutic advances in Alzheimer's disease , 1999, Nature.

[56]  J. Vickers.  A Vaccine Against Alzheimer’s Disease , 2002 .

[57]  R. Motter,et al.  Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse , 1999, Nature.

[58]  M. Witter,et al.  Functional MR imaging in Alzheimer's disease during memory encoding. , 2000, AJNR. American journal of neuroradiology.

[59]  Nick C Fox,et al.  Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects. , 2000, Archives of neurology.

[60]  G. Alexander,et al.  Association between brain functional failure and dementia severity in Alzheimer's disease: resting versus stimulation PET study. , 1999, The American journal of psychiatry.

[61]  J. Corwin,et al.  Nicotinic treatment of Alzheimer’s disease , 2001, Biological Psychiatry.

[62]  R. V. Van Heertum,et al.  SPECT perfusion imaging in the diagnosis of Alzheimer’s disease , 2001, Neurology.

[63]  R. Mahley,et al.  Apolipoprotein E. Structure, Function, and Possible Roles in Alzheimer's Disease a , 1996, Annals of the New York Academy of Sciences.

[64]  I. Grundke‐Iqbal,et al.  Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. , 1996, Brain research. Molecular brain research.

[65]  G. Multhaup,et al.  Alzheimer's disease: genesis of amyloid. , 1996, Ciba Foundation symposium.

[66]  G. Small,et al.  Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. , 2002, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[67]  T Ernst,et al.  Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. , 1997, Radiology.

[68]  T. Ohnishi,et al.  Longitudinal Evaluation of Early Alzheimer's Disease Using Brain Perfusion Spect the Recruitment Was For , 2000 .

[69]  S Kobashi,et al.  Frontotemporal dementia and Alzheimer disease: evaluation of cortical atrophy with automated hemispheric surface display generated with MR images. , 1998, Radiology.

[70]  G. Alexander,et al.  Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. , 2001, JAMA.

[71]  C. Jack,et al.  Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment , 1999, Neurology.

[72]  Sarah Tomlin,et al.  Microtechnology: Laying it on thick , 1999, Nature.