Mitochondrially targeted anti-cancer agents.

[1]  N. Sassi,et al.  Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes. , 2010, Biochimica et biophysica acta.

[2]  M. Zoratti,et al.  Electrophysiology clarifies the megariddles of the mitochondrial permeability transition pore , 2010, FEBS letters.

[3]  M. Zoratti,et al.  Contribution of voltage‐gated potassium channels to the regulation of apoptosis , 2010, FEBS letters.

[4]  S. Pervaiz,et al.  The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. , 2010, The international journal of biochemistry & cell biology.

[5]  J. Neuzil,et al.  α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels , 2010, Apoptosis.

[6]  A. Scheepens,et al.  Improving the oral bioavailability of beneficial polyphenols through designed synergies , 2010, Genes & Nutrition.

[7]  T. Fujiwara,et al.  Intracellular fate of octaarginine-modified liposomes in polarized MDCK cells. , 2010, International journal of pharmaceutics.

[8]  Qingming Luo,et al.  HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting. , 2010, Small.

[9]  R. Moreno-Sánchez,et al.  Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. , 2010, Molecular aspects of medicine.

[10]  Yaping Li,et al.  The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model. , 2010, Biomaterials.

[11]  N. Sassi,et al.  Impact of mitochondriotropic quercetin derivatives on mitochondria. , 2010, Biochimica et biophysica acta.

[12]  K. Murao,et al.  Inhibition of cytochrome c release by 10-N-nonyl acridine orange, a cardiolipin-specific dye, during myocardial ischemia-reperfusion in the rat. , 2010, American journal of physiology. Heart and circulatory physiology.

[13]  P. Bernardi,et al.  Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition , 2009, Proceedings of the National Academy of Sciences.

[14]  W. Craigen,et al.  VDAC2 is required for truncated BID‐induced mitochondrial apoptosis by recruiting BAK to the mitochondria , 2009, EMBO reports.

[15]  M. Zoratti,et al.  Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols. , 2009, Biochimica et biophysica acta.

[16]  J. Klein-Seetharaman,et al.  Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. , 2009, Advanced drug delivery reviews.

[17]  Divya Pathania,et al.  Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism. , 2009, Advanced drug delivery reviews.

[18]  Y. Yeo,et al.  Nanoparticles for tumor-specific intracellular drug delivery , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[19]  D. Hedley,et al.  Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer , 2009, Molecular Pharmacology.

[20]  Zhiwei Wang,et al.  Cellular signaling perturbation by natural products. , 2009, Cellular signalling.

[21]  Carlotta Giorgi,et al.  Ca(2+) transfer from the ER to mitochondria: when, how and why. , 2009, Biochimica et biophysica acta.

[22]  L. Galluzzi,et al.  Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery , 2009, Cell Death and Differentiation.

[23]  S. Pervaiz,et al.  Resveratrol: its biologic targets and functional activity. , 2009, Antioxidants & redox signaling.

[24]  W. Craigen,et al.  Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax , 2009, Oncogene.

[25]  M. Klingenberg Cardiolipin and mitochondrial carriers. , 2009, Biochimica et biophysica acta.

[26]  S. Claypool Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function. , 2009, Biochimica et Biophysica Acta.

[27]  Joaquín Jordán,et al.  Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria‐mediated cell death , 2009, British journal of pharmacology.

[28]  G. Kroemer,et al.  Targeting mitochondrial apoptosis by betulinic acid in human cancers. , 2009, Drug discovery today.

[29]  R. O. Poyton,et al.  Mitochondrial generation of free radicals and hypoxic signaling , 2009, Trends in Endocrinology & Metabolism.

[30]  A. Vercesi,et al.  Mitochondria and reactive oxygen species. , 2009, Free radical biology & medicine.

[31]  R. Bellamkonda,et al.  Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors. , 2009, Biomaterials.

[32]  Benjamin Thierry,et al.  Drug nanocarriers and functional nanoparticles: applications in cancer therapy. , 2009, Current drug delivery.

[33]  P. Matarrese,et al.  The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis , 2009, Cell Death and Differentiation.

[34]  S. Sollott,et al.  Regulation and pharmacology of the mitochondrial permeability transition pore. , 2009, Cardiovascular research.

[35]  M. Ristow,et al.  Small‐Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag , 2009, Chembiochem : a European journal of chemical biology.

[36]  Peng Huang,et al.  Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.

[37]  K. Burgess,et al.  New cytotoxic rosamine derivatives selectively accumulate in the mitochondria of cancer cells , 2009, Anti-cancer drugs.

[38]  H. Bayır,et al.  Mitochondria‐targeted (2‐hydroxyamino‐vinyl)‐triphenyl‐phosphonium releases NO and protects mouse embryonic cells against irradiation‐induced apoptosis , 2009, FEBS letters.

[39]  David R Bickers,et al.  Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. , 2009, Archives of biochemistry and biophysics.

[40]  T. Miura,et al.  GSK-3β, a Therapeutic Target for Cardiomyocyte Protection , 2009 .

[41]  S. Sollott,et al.  Role of Glycogen Synthase Kinase-3β in Cardioprotection , 2009, Circulation research.

[42]  A. Halestrap What is the mitochondrial permeability transition pore? , 2009, Journal of molecular and cellular cardiology.

[43]  V. Shoshan-Barmatz,et al.  The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins , 2009, Journal of Cell Science.

[44]  Chonglin Yang,et al.  Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery To Promote Apoptosis in Caenorhabditis elegans , 2009, Molecular and Cellular Biology.

[45]  D. Wallace,et al.  Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults. , 2009, Biochimica et biophysica acta.

[46]  L. A. Obukhova,et al.  An attempt to prevent senescence: a mitochondrial approach. , 2009, Biochimica et biophysica acta.

[47]  M. Rapoport,et al.  TAT-based drug delivery system – new directions in protein delivery for new hopes? , 2009 .

[48]  V. Shoshan-Barmatz,et al.  Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase. , 2009, Biochimica et biophysica acta.

[49]  M. Zoratti,et al.  Novel channels of the inner mitochondrial membrane. , 2009, Biochimica et biophysica acta.

[50]  Peng Huang,et al.  Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate. , 2009, Biochimica et biophysica acta.

[51]  Y. Yeo,et al.  Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. , 2009, Molecular pharmaceutics.

[52]  P. Pinton,et al.  Mitochondria, calcium and cell death: a deadly triad in neurodegeneration. , 2009, Biochimica et biophysica acta.

[53]  Laurent Schwartz,et al.  Novel therapy for malignant pleural mesothelioma based on anti-energetic effect: an experimental study using 3-Bromopyruvate on nude mice. , 2009, Anticancer research.

[54]  R. Moreno-Sánchez,et al.  Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II , 2009, Clinical Cancer Research.

[55]  M. Giorgio,et al.  Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase , 2009, Basic Research in Cardiology.

[56]  V. Shoshan-Barmatz,et al.  Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity* , 2009, Journal of Biological Chemistry.

[57]  A. Lena,et al.  Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells , 2009, Journal of Translational Medicine.

[58]  Saroj P. Mathupala,et al.  Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. , 2009, Seminars in cancer biology.

[59]  N. Hay,et al.  Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. , 2009, Seminars in cancer biology.

[60]  Jayanth Panyam,et al.  Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery. , 2009, Biomaterials.

[61]  R. Mumper,et al.  Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. , 2009, Cancer treatment reviews.

[62]  J. Medema,et al.  Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion , 2009, Apoptosis.

[63]  A. Mukherjee,et al.  Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability. , 2009, Anti-cancer agents in medicinal chemistry.

[64]  Nathan R. Perron,et al.  A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding , 2009, Cell Biochemistry and Biophysics.

[65]  K. Ying,et al.  Down‐regulation of adenine nucleotide translocase 3 and its role in camptothecin‐induced apoptosis in human hepatoma QGY7703 cells , 2009, FEBS letters.

[66]  S. Futaki,et al.  Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment , 2009, The AAPS Journal.

[67]  X. Weng,et al.  Novel anthraquinone derivatives: synthesis via click chemistry approach and their induction of apoptosis in BGC gastric cancer cells via reactive oxygen species (ROS)-dependent mitochondrial pathway. , 2008, Bioorganic & medicinal chemistry letters.

[68]  Michael P. Murphy,et al.  How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.

[69]  H. Szeto Development of Mitochondria‐targeted Aromatic‐cationic Peptides for Neurodegenerative Diseases , 2008, Annals of the New York Academy of Sciences.

[70]  M. Lichinitser,et al.  Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells , 2008, Biochemistry (Moscow).

[71]  L. Johannes,et al.  Synthesis and Properties of a Mitochondrial Peripheral Benzodiazepine Receptor Conjugate , 2008, ChemMedChem.

[72]  N. Sassi,et al.  A Mitochondriotropic Derivative of Quercetin: A Strategy to Increase the Effectiveness of Polyphenols , 2008, Chembiochem : a European journal of chemical biology.

[73]  P. Pinton,et al.  Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis , 2008, Oncogene.

[74]  H. Gourdeau,et al.  Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand , 2008, Cancer Chemotherapy and Pharmacology.

[75]  N. Sassi,et al.  Development of mitochondria-targeted derivatives of resveratrol. , 2008, Bioorganic & medicinal chemistry letters.

[76]  J. K. Kundu,et al.  Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. , 2008, Cancer letters.

[77]  Akira Murakami,et al.  Multitargeted cancer prevention by quercetin. , 2008, Cancer letters.

[78]  H. Harashima,et al.  Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. , 2008, Advanced drug delivery reviews.

[79]  F. Lang,et al.  Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes , 2008, Proceedings of the National Academy of Sciences.

[80]  G. Parmigiani,et al.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.

[81]  D. Busam,et al.  An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2008, Science.

[82]  P. Pedersen Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment’s roles together with hexokinase-2 in the “Warburg effect” in cancer , 2008, Journal of bioenergetics and biomembranes.

[83]  E. Hayden Cancer complexity slows quest for cure , 2008, Nature.

[84]  S. Futaki,et al.  Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape* , 2008, Journal of Biological Chemistry.

[85]  B. Halliwell Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? , 2008, Archives of biochemistry and biophysics.

[86]  V. Shoshan-Barmatz,et al.  Methyl jasmonate binds to and detaches mitochondria-bound hexokinase , 2008, Oncogene.

[87]  C. Stein,et al.  Specific VDAC inhibitors: phosphorothioate oligonucleotides , 2008, Journal of bioenergetics and biomembranes.

[88]  V. Shoshan-Barmatz,et al.  Uncovering the role of VDAC in the regulation of cell life and death , 2008, Journal of bioenergetics and biomembranes.

[89]  J. Geschwind,et al.  Development of a new orthotopic animal model of metastatic liver cancer in the rabbit VX2 model: effect on metastases after partial hepatectomy, intra-arterial treatment with 3-bromopyruvate and chemoembolization , 2008, Clinical & Experimental Metastasis.

[90]  F. Domann,et al.  α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II , 2008, Oncogene.

[91]  V. Torchilin,et al.  Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. , 2008, Nano letters.

[92]  S. Sang,et al.  Bioavailability issues in studying the health effects of plant polyphenolic compounds. , 2008, Molecular nutrition & food research.

[93]  Paul Talalay,et al.  Direct and indirect antioxidant properties of inducers of cytoprotective proteins. , 2008, Molecular nutrition & food research.

[94]  M. E. Kenney,et al.  Targeting of mitochondria by 10-N-alkyl acridine orange analogues: role of alkyl chain length in determining cellular uptake and localization. , 2008, Mitochondrion.

[95]  P. Petit,et al.  Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis* , 2008, Journal of Biological Chemistry.

[96]  Robin A. J. Smith,et al.  Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. , 2008, The Biochemical journal.

[97]  K. Sugimura,et al.  DNA polymerase γ inhibition by vitamin K3 induces mitochondria‐mediated cytotoxicity in human cancer cells , 2008, Cancer science.

[98]  C. Zazueta,et al.  Titration of cardiolipin by either 10-N-nonyl acridine orange or acridine orange sensitizes the adenine nucleotide carrier to permeability transition , 2008, Journal of bioenergetics and biomembranes.

[99]  S. Futaki,et al.  Octaarginine-modified liposomes: enhanced cellular uptake and controlled intracellular trafficking. , 2008, International journal of pharmaceutics.

[100]  Shusheng Zhang,et al.  A novel benzotriazole derivative inhibits proliferation of human hepatocarcinoma cells by increasing oxidative stress concomitant mitochondrial damage. , 2008, European journal of pharmacology.

[101]  B. Zhivotovsky,et al.  Mitochondria in cancer cells: what is so special about them? , 2008, Trends in cell biology.

[102]  M. Knopp,et al.  Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor , 2008, Clinical Cancer Research.

[103]  V. Tyurin,et al.  Activation of NO donors in mitochondria: Peroxidase metabolism of (2‐hydroxyamino‐vinyl)‐triphenyl‐phosphonium by cytochrome c releases NO and protects cells against apoptosis , 2008, FEBS letters.

[104]  Yuma Yamada,et al.  Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system. , 2008, Advanced drug delivery reviews.

[105]  Vladimir P Torchilin,et al.  Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers. , 2008, Advanced drug delivery reviews.

[106]  Y. Jeon,et al.  Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo , 2008, Breast Cancer Research.

[107]  Takenori Yamamoto,et al.  MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. , 2008, Biochimica et biophysica acta.

[108]  H. Szeto Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. , 2008, Antioxidants & redox signaling.

[109]  Xiu-fang Wang,et al.  Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress. , 2007, Cancer research.

[110]  D. Albert,et al.  Mitochondria, Calcium, and Calpain are Key Mediators of Resveratrol-Induced Apoptosis in Breast Cancer , 2007, Molecular Pharmacology.

[111]  Shengcai Lin,et al.  Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. , 2007, Molecular biology of the cell.

[112]  M. Sousa,et al.  ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis , 2007, Molecular microbiology.

[113]  Kevin D Cooper,et al.  Photodynamic therapy with the phthalocyanine photosensitizer Pc 4: the case experience with preclinical mechanistic and early clinical-translational studies. , 2007, Toxicology and applied pharmacology.

[114]  S. Dikalov,et al.  Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis. , 2007, Antioxidants & redox signaling.

[115]  V. Baladandayuthapani,et al.  Targeting cell signaling pathways for drug discovery: An old lock needs a new key , 2007, Journal of cellular biochemistry.

[116]  K. Kogure,et al.  Multifunctional envelope-type nano device for non-viral gene delivery: concept and application of Programmed Packaging. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[117]  Xiu-fang Wang,et al.  Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. , 2007, Molecular aspects of medicine.

[118]  N. Pfanner,et al.  Motor-free mitochondrial presequence translocase drives membrane integration of preproteins , 2007, Nature Cell Biology.

[119]  G. Cheon,et al.  Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma , 2007, Molecular Cancer Therapeutics.

[120]  Stefan Trapp,et al.  Mitochondriotropics: a review of their mode of action, and their applications for drug and DNA delivery to mammalian mitochondria. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[121]  A. Leslie,et al.  Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols , 2007, Proceedings of the National Academy of Sciences.

[122]  V. Papadopoulos,et al.  The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. , 2007, Cell calcium.

[123]  Yan Zhao,et al.  Vitamin E Analogs, a Novel Group of “Mitocans,” as Anticancer Agents: The Importance of Being Redox-Silent , 2007, Molecular Pharmacology.

[124]  Y. Tsujimoto,et al.  Role of the mitochondrial membrane permeability transition in cell death , 2007, Apoptosis.

[125]  B. Zhivotovsky,et al.  Role of cardiolipin in cytochrome c release from mitochondria , 2007, Cell Death and Differentiation.

[126]  Marc Birringer,et al.  A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. , 2007, Cancer research.

[127]  Andrew D. Johnson,et al.  Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells , 2007, Molecular Cancer Therapeutics.

[128]  P. Bernardi,et al.  The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis , 2007, Apoptosis.

[129]  Yuma Yamada,et al.  Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria. , 2007, Mitochondrion.

[130]  Feng Yang,et al.  Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin. , 2007, Journal of structural biology.

[131]  Robin A. J. Smith,et al.  Targeting antioxidants to mitochondria by conjugation to lipophilic cations. , 2007, Annual review of pharmacology and toxicology.

[132]  Sten Orrenius,et al.  Mitochondrial oxidative stress: implications for cell death. , 2007, Annual review of pharmacology and toxicology.

[133]  Vladimir P Torchilin,et al.  Enhanced transfection of tumor cells in vivo using “Smart” pH-sensitive TAT-modified pegylated liposomes , 2007, Journal of drug targeting.

[134]  S. Muller,et al.  Peptido-targeting of the mitochondrial transition pore complex for therapeutic apoptosis induction. , 2006, Current pharmaceutical design.

[135]  John Calvin Reed,et al.  Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). , 2006, Blood.

[136]  Xiu-fang Wang,et al.  Molecular mechanism of ‘mitocan’‐induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl‐2 family proteins , 2006, FEBS letters.

[137]  G. Kroemer,et al.  Chemosensitization by knockdown of adenine nucleotide translocase-2. , 2006, Cancer research.

[138]  P. Leder,et al.  Mitochondriotoxic compounds for cancer therapy , 2006, Oncogene.

[139]  D. Nutt,et al.  Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. , 2006, Trends in pharmacological sciences.

[140]  Vladimir P Torchilin,et al.  Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. , 2006, Annual review of biomedical engineering.

[141]  Shishir Shishodia,et al.  Molecular targets of dietary agents for prevention and therapy of cancer. , 2006, Biochemical pharmacology.

[142]  L. Gerweck,et al.  Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics , 2006, Molecular Cancer Therapeutics.

[143]  Fabio Di Lisa,et al.  The mitochondrial permeability transition from in vitro artifact to disease target , 2006, The FEBS journal.

[144]  Catarina R. Oliveira,et al.  Tamoxifen and Estradiol Interact with the Flavin Mononucleotide Site of Complex I Leading to Mitochondrial Failure* , 2006, Journal of Biological Chemistry.

[145]  Shiroh Futaki,et al.  High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression* , 2006, Journal of Biological Chemistry.

[146]  I. Hassinen,et al.  A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates , 2006, British journal of pharmacology.

[147]  Volkmar Weissig,et al.  Liposomes and Liposome-like Vesicles for Drug and DNA Delivery to Mitochondria , 2006, Journal of liposome research.

[148]  M. Zoratti,et al.  Electrophysiological characterization of the Cyclophilin D-deleted mitochondrial permeability transition pore , 2006, Molecular membrane biology.

[149]  V. Torchilin,et al.  Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-alpha-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin. , 2005, International journal of pharmaceutics.

[150]  Yasuo Shinohara,et al.  Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy. , 2005, International journal of pharmaceutics.

[151]  L. Ghibelli,et al.  Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[152]  Qing Zhao,et al.  Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors , 2005, Nature chemical biology.

[153]  P. Witting,et al.  α-Tocopheryl Succinate Inhibits Malignant Mesothelioma by Disrupting the Fibroblast Growth Factor Autocrine Loop , 2005, Journal of Biological Chemistry.

[154]  P. Bernardi,et al.  Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D* , 2005, Journal of Biological Chemistry.

[155]  F. Lang,et al.  A Novel Potassium Channel in Lymphocyte Mitochondria* , 2005, Journal of Biological Chemistry.

[156]  Jeffrey Robbins,et al.  Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death , 2005, Nature.

[157]  V. Shoshan-Barmatz,et al.  Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria. , 2005, The Biochemical journal.

[158]  V. Torchilin Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[159]  A. Girotti,et al.  Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells. , 2005, Archives of biochemistry and biophysics.

[160]  Peng Huang,et al.  Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. , 2005, Cancer research.

[161]  S. Pervaiz,et al.  Hydrogen Peroxide-Mediated Cytosolic Acidification Is a Signal for Mitochondrial Translocation of Bax during Drug-Induced Apoptosis of Tumor Cells , 2004, Cancer Research.

[162]  G. Kroemer,et al.  Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis , 2004, Oncogene.

[163]  D. Decaudin Peripheral benzodiazepine receptor and its clinical targeting. , 2004, Anti-cancer drugs.

[164]  D. Green,et al.  The Pathophysiology of Mitochondrial Cell Death , 2004, Science.

[165]  Kazuo Maruyama,et al.  Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. , 2004, Biochemistry.

[166]  M. Granell,et al.  Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells , 2004, FEBS letters.

[167]  Peng Huang,et al.  ROS stress in cancer cells and therapeutic implications. , 2004, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[168]  Dean P. Jones,et al.  The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore , 2004, Nature.

[169]  V. Shoshan-Barmatz,et al.  In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. , 2004, The Biochemical journal.

[170]  C. Brenner,et al.  The adenine nucleotide translocator: a new potential chemotherapeutic target. , 2003, Current drug targets.

[171]  C. Brenner,et al.  The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. , 2003, Current medicinal chemistry.

[172]  S. Galiègue,et al.  The peripheral benzodiazepine receptor: a promising therapeutic drug target. , 2003, Current medicinal chemistry.

[173]  M. E. Kidd,et al.  The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations. , 2003, Cancer letters.

[174]  J. Folkman,et al.  A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. , 2003, Cancer cell.

[175]  P. Pedersen,et al.  Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. , 2002, Cancer research.

[176]  Luca Scorrano,et al.  A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. , 2002, Cancer cell.

[177]  W. Miller Molecular targets of arsenic trioxide in malignant cells. , 2002, The oncologist.

[178]  J. Eaton,et al.  Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. , 2002, The Biochemical journal.

[179]  G. Kroemer,et al.  Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo. , 2002, Cancer research.

[180]  G. Kroemer,et al.  The adenine nucleotide translocator in apoptosis. , 2002, Biochimie.

[181]  Sten Orrenius,et al.  Cytochrome c release from mitochondria proceeds by a two-step process , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[182]  G. Kroemer,et al.  Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437 , 2001, Oncogene.

[183]  J. Modica-Napolitano,et al.  Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. , 2001, Advanced drug delivery reviews.

[184]  L. Gerweck,et al.  The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics. , 2001, Cancer research.

[185]  Robin A. J. Smith,et al.  Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells , 2001, The Journal of Biological Chemistry.

[186]  R. Coffey,et al.  Induction of cancer cell apoptosis by α‐tocopheryl succinate: molecular pathways and structural requirements , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[187]  Y. Tsujimoto,et al.  Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells , 2001, The Journal of cell biology.

[188]  Paul J Thornalley,et al.  Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro. , 2001, Biochemical pharmacology.

[189]  J. Neuzil,et al.  Selective cancer cell killing by α-tocopheryl succinate , 2001, British Journal of Cancer.

[190]  Y. Tsujimoto,et al.  VDAC regulation by the Bcl-2 family of proteins , 2000, Cell Death and Differentiation.

[191]  G. Kroemer,et al.  Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator , 2000, Cell Death and Differentiation.

[192]  A. Driessen,et al.  The uncoupling efficiency and affinity of flavonoids for vesicles. , 2000, Biochemical pharmacology.

[193]  Jianbiao Zheng,et al.  Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals , 2000, British journal of pharmacology.

[194]  D. Andrews,et al.  Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator , 2000, Oncogene.

[195]  Erkki Ruoslahti,et al.  Anti-cancer activity of targeted pro-apoptotic peptides , 1999, Nature Medicine.

[196]  J. Neuzil,et al.  α‐Tocopheryl succinate‐induced apoptosis in Jurkat T cells involves caspase‐3 activation, and both lysosomal and mitochondrial destabilisation , 1999, FEBS letters.

[197]  M. Peter,et al.  Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid* , 1998, The Journal of Biological Chemistry.

[198]  T. Kubota,et al.  Selective antitumor activity of MKT‐077, a delocalized lipophilic cation, on normal cells and cancer cells in vitro , 1998, Journal of surgical oncology.

[199]  J C Reed,et al.  Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. , 1998, Science.

[200]  H. Tapiero,et al.  Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells , 1997, Leukemia.

[201]  Rakesh K. Jain,et al.  Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.

[202]  R. Jain,et al.  Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. , 1996, British Journal of Cancer.

[203]  E. Levine,et al.  Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[204]  L. Gerweck,et al.  Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. , 1996, Cancer research.

[205]  M. Zoratti,et al.  The mitochondrial permeability transition. , 1995, Biochimica et biophysica acta.

[206]  R K Jain,et al.  Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. , 1994, Cancer research.

[207]  S. Liao,et al.  Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. , 1993, Journal of pharmaceutical sciences.

[208]  H. Tapiero,et al.  Structural requirements of simple organic cations for recognition by multidrug-resistant cells. , 1992, Cancer research.

[209]  J. J. Nadakavukaren,et al.  Increased rhodamine 123 uptake by carcinoma cells. , 1985, Cancer research.

[210]  T. Lampidis,et al.  Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells. , 1985, The Journal of biological chemistry.

[211]  I. Summerhayes,et al.  Selective toxicity of rhodamine 123 in carcinoma cells in vitro. , 1983, Cancer research.

[212]  I. Summerhayes,et al.  Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. , 1982, Science.

[213]  V. Skulachev,et al.  Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria , 1969, Nature.

[214]  D. Rubinsztein,et al.  Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. , 2010, Free radical biology & medicine.

[215]  M. Beal,et al.  Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. , 2010, Biochimica et biophysica acta.

[216]  E. Rieber,et al.  GD3-7-aldehyde is an apoptosis inducer and interacts with adenine nucleotide translocase. , 2010, Biochemical and biophysical research communications.

[217]  G. Di Trapani,et al.  Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy. , 2009, Molecular nutrition & food research.

[218]  M. Shakibaei,et al.  Resveratrol addiction: to die or not to die. , 2009, Molecular nutrition & food research.

[219]  L. Andĕra,et al.  Future use of mitocans against tumour-initiating cells? , 2009, Molecular nutrition & food research.

[220]  J. Neuzil,et al.  Mitochondria as targets for cancer therapy. , 2009, Molecular nutrition & food research.

[221]  R. Moreno-Sánchez,et al.  Targeting of cancer energy metabolism. , 2009, Molecular nutrition & food research.

[222]  Linlin Lu,et al.  Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells , 2009, Cancer Chemotherapy and Pharmacology.

[223]  H. Bayır,et al.  Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. , 2009, Molecular nutrition & food research.

[224]  O. S. E. Dein Role of the permeability transition pore complex in lethal inter-organelle crosstalk , 2009 .

[225]  Y. Jeon,et al.  BMC Cancer BioMed Central Research article Over-expression of Adenine Nucleotide Translocase 1 (ANT1) Induces Apoptosis and Tumor Regression in vivo , 2008 .

[226]  Gary Williamson,et al.  Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. , 2005, The American journal of clinical nutrition.

[227]  Volkmar Weissig,et al.  Mitochondrial-targeted drug and DNA delivery. , 2003, Critical reviews in therapeutic drug carrier systems.

[228]  L. B. Chen,et al.  Mitochondrial membrane potential in living cells. , 1988, Annual review of cell biology.

[229]  G. Azzone,et al.  Determination of the Proton Electrochemical Gradient across Biological Membranes , 1984 .