Seropositivity of Dengue Antibodies during Pregnancy

Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM) using an enzyme-linked immunosorbent assay (ELISA). Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU) were analyzed. Results. Out of 358 women recruited, about 128 (35.8%) patients were seropositive. Twelve patients (3.4%) had recent infections (IgM positive) and another 116 women (32.4%) were with past infections (IgG positive). All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission. Conclusion. In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes.

[1]  A. I. Souza,et al.  Dengue infection in pregnancy and transplacental transfer of anti-dengue antibodies in Northeast, Brazil. , 2014, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[2]  Seetha Panicker,et al.  Maternal and fetal outcome of dengue fever in pregnancy. , 2011, Journal of vector borne diseases.

[3]  S. Omar,et al.  Dengue Infection in Pregnancy: Prevalence, Vertical Transmission, and Pregnancy Outcome , 2008, Obstetrics and gynecology.

[4]  S. Devi,et al.  Rapid detection, serotyping and quantitation of dengue viruses by TaqMan real-time one-step RT-PCR. , 2006, Journal of virological methods.

[5]  G. Malavige,et al.  Dengue infections during pregnancy: a case series from Sri Lanka and review of the literature. , 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[6]  P. Newton,et al.  A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. , 2006, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[7]  Z. Mahdy,et al.  Dengue in pregnancy. , 2006, The Southeast Asian journal of tropical medicine and public health.

[8]  B. Brabin,et al.  Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers. , 2005, The Journal of infection.

[9]  W. S. Chen,et al.  Dengue antibodies in a suburban community in Malaysia. , 2003, The Medical journal of Malaysia.

[10]  D. Gubler,et al.  Dengue and dengue hemorrhagic fever. , 2014 .

[11]  S. Lam,et al.  Vertical transmission of dengue. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  H. Schatzmayr,et al.  Levels of IgM antibodies against dengue virus in Rio de Janeiro, Brazil. , 1992, Research in virology.

[13]  A. Nisalak,et al.  Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. , 1988, The American journal of tropical medicine and hygiene.