Common fragile sites.

[1]  D. Beer,et al.  Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma , 2006, Oncogene.

[2]  T. Glover,et al.  Mechanisms of common fragile site instability. , 2005, Human molecular genetics.

[3]  K. Friend,et al.  Common chromosomal fragile site FRA16D mutation in cancer cells. , 2005, Human molecular genetics.

[4]  T. Ørntoft,et al.  DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis , 2005, Nature.

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[6]  T. Petes,et al.  Chromosomal Translocations in Yeast Induced by Low Levels of DNA Polymerase A Model for Chromosome Fragile Sites , 2005, Cell.

[7]  A. D’Andrea,et al.  The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. , 2005, Human molecular genetics.

[8]  T. Ried,et al.  SMC1 involvement in fragile site expression. , 2005, Human molecular genetics.

[9]  T. Glover,et al.  Chromosomal instability at common fragile sites in Seckel syndrome. , 2004, American journal of human genetics.

[10]  F. Apiou,et al.  Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer , 2004, Oncogene.

[11]  M. Kastan,et al.  BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function , 2004, Molecular and Cellular Biology.

[12]  M. Sasaki,et al.  Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks , 2004, Cytogenetic and Genome Research.

[13]  M. L. Le Beau,et al.  The role of late/slow replication of the FRA16D in common fragile site induction , 2004, Genes, chromosomes & cancer.

[14]  C. Croce,et al.  Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  S. Scherer,et al.  Molecular Basis for Expression of Common and Rare Fragile Sites , 2003, Molecular and Cellular Biology.

[16]  David I. Smith,et al.  Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer , 2003, Genes, chromosomes & cancer.

[17]  M. Z. Limongi,et al.  Characterization of the human common fragile site FRA2G. , 2003, Genomics.

[18]  David I. Smith,et al.  Characterization of the common fragile site FRA9E and its potential role in ovarian cancer , 2003, Oncogene.

[19]  T. Glover,et al.  ATR Regulates Fragile Site Stability , 2002, Cell.

[20]  David I. Smith,et al.  Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors , 2002, Oncogene.

[21]  Bo Xu,et al.  Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. , 2002, Cancer research.

[22]  N. Kleckner,et al.  ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones , 2002, Science.

[23]  R. Espinosa,et al.  Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors. , 2002, Cancer research.

[24]  Jeremy M. Stark,et al.  ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair* , 2002, The Journal of Biological Chemistry.

[25]  E. Calhoun,et al.  The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1 , 2002, Genes, chromosomes & cancer.

[26]  A. Giaccia,et al.  Hypoxia Links ATR and p53 through Replication Arrest , 2002, Molecular and Cellular Biology.

[27]  J. Bartek,et al.  The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways , 2002, Nature Genetics.

[28]  S. Schreiber,et al.  ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint* , 2002, The Journal of Biological Chemistry.

[29]  David I. Smith,et al.  A role for common fragile site induction in amplification of human oncogenes. , 2002, Cancer cell.

[30]  D. Beer,et al.  Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells , 2002, Genes, chromosomes & cancer.

[31]  Junjie Chen,et al.  Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress* , 2001, The Journal of Biological Chemistry.

[32]  C. Croce,et al.  FRA3B and other common fragile sites: the weakest links , 2001, Nature Reviews Cancer.

[33]  Jun Qin,et al.  ATR and ATRIP: Partners in Checkpoint Signaling , 2001, Science.

[34]  A. Brenner,et al.  WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. , 2001, Cancer research.

[35]  S. Lambert,et al.  Role of RAD51 in sister-chromatid exchanges in mammalian cells , 2001, Oncogene.

[36]  D J Porteous,et al.  WWOX: A candidate tumor suppressor gene involved in multiple tumor types , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[37]  C. de la Torre,et al.  Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes. , 2001, Mutagenesis.

[38]  R. Abraham.  Cell cycle checkpoint signaling through the ATM and ATR kinases. , 2001, Genes & development.

[39]  C. Croce,et al.  The tumor spectrum in FHIT-deficient mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Schreiber,et al.  ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Bo Xu,et al.  Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation , 2001, Molecular and Cellular Biology.

[42]  W. Miller,et al.  Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[43]  D. Durocher,et al.  DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? , 2001, Current opinion in cell biology.

[44]  D. Beer,et al.  Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma , 2001, Genes, chromosomes & cancer.

[45]  Y. Shiloh.  ATM and ATR: networking cellular responses to DNA damage. , 2001, Current opinion in genetics & development.

[46]  M. Jasin,et al.  BRCA2 is required for homology-directed repair of chromosomal breaks. , 2001, Molecular cell.

[47]  F. Toledo,et al.  Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility. , 2000, Nucleic acids research.

[48]  S. Elledge,et al.  Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. , 2000, Genes & development.

[49]  M. W. Glynn,et al.  Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. , 2000, American journal of human genetics.

[50]  David I. Smith,et al.  Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites. , 2000, Cancer research.

[51]  D. Gilbert,et al.  Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis , 2000, Nature Cell Biology.

[52]  R. Richards,et al.  Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. , 2000, Human molecular genetics.

[53]  Stephen W. Scherer,et al.  Replication Delay along FRA7H, a Common Fragile Site on Human Chromosome 7, Leads to Chromosomal Instability , 2000, Molecular and Cellular Biology.

[54]  J. Hoeijmakers,et al.  Mouse RAD54 Affects DNA Double-Strand Break Repair and Sister Chromatid Exchange , 2000, Molecular and Cellular Biology.

[55]  A. Bednarek,et al.  WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. , 2000, Cancer research.

[56]  J. Sgouros,et al.  A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D. , 2000, Cancer research.

[57]  D. Baltimore,et al.  ATR disruption leads to chromosomal fragmentation and early embryonic lethality. , 2000, Genes & development.

[58]  J. Sarkaria,et al.  Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. , 1999, Cancer research.

[59]  C. Croce,et al.  Cancer-specific chromosome alterations in the constitutive fragile region FRA3B. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[60]  B. Kerem,et al.  Common fragile sites: G-band characteristics within an R-band. , 1999, American journal of human genetics.

[61]  W. Liu,et al.  Allele-specific late replication and fragility of the most active common fragile site, FRA3B. , 1999, Human molecular genetics.

[62]  Haojie Huang,et al.  Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer , 1999, Genes, chromosomes & cancer.

[63]  R. Richards,et al.  Fragile sites still breaking. , 1998, Trends in genetics : TIG.

[64]  J. Engelman,et al.  Genes encoding human caveolin‐1 and ‐2 are co‐localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers , 1998, FEBS letters.

[65]  F. Li,et al.  The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[66]  D. Beer,et al.  The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. , 1998, Cancer research.

[67]  S. Scherer,et al.  Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[68]  David I. Smith,et al.  FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites , 1998, Oncogene.

[69]  R I Richards,et al.  FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis. , 1998, Molecular cell.

[70]  R. Espinosa,et al.  Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. , 1998, Human molecular genetics.

[71]  L. D. Barnes,et al.  Replacement of Fhit in cancer cells suppresses tumorigenicity. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[72]  D. Beer,et al.  Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas , 1997, Oncogene.

[73]  B. McAllister,et al.  How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus) , 1997, Human Genetics.

[74]  T. Canfield,et al.  A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[75]  F. Toledo,et al.  Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons , 1997, Cell.

[76]  H. Klinger,et al.  Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. , 1997, Human molecular genetics.

[77]  C. Croce,et al.  Structure and expression of the human FHIT gene in normal and tumor cells. , 1997, Cancer research.

[78]  A. C. Chinault,et al.  Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE. , 1996, American journal of human genetics.

[79]  C. Croce,et al.  The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers , 1996, Cell.

[80]  T. Glover,et al.  FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. , 1996, Human molecular genetics.

[81]  S. S. Smith,et al.  Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[82]  T. Glover,et al.  Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3. , 1995, Genomics.

[83]  D. Paslier,et al.  Integrated YAC contig containing the 3pl4.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B , 1994, Genes, chromosomes & cancer.

[84]  W. Hittelman,et al.  Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells , 1994, Molecular and cellular biology.

[85]  T. Glover,et al.  Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma. , 1994, Genomics.

[86]  M. Y. Yang,et al.  Folate sensitive common fragile sites in chromosomes of the domestic pig (Sus scrofa). , 1993, Research in veterinary science.

[87]  J. Testa,et al.  Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. , 1993, Genomics.

[88]  T. Canfield,et al.  Association of fragile X syndrome with delayed replication of the FMR1 gene , 1993, Cell.

[89]  J. Doles,et al.  Folate-sensitive and aphidicolin-inducible fragile sites are expressed in the genome of the domestic cat. , 1993, Cancer genetics and cytogenetics.

[90]  J. McDougall,et al.  Viral integration and fragile sites in human papillomavirus‐lmmortalized human keratinocyte cell lines , 1992, Genes, chromosomes & cancer.

[91]  O. Haas,et al.  Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma. , 1992, Cancer genetics and cytogenetics.

[92]  D. Hancock,et al.  Animal model: Chromosomal fragile site expression in dogs: I. Breed specific differences , 1991 .

[93]  R. Espinosa,et al.  Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[94]  R I Richards,et al.  Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n , 1991, Science.

[95]  A. Carrano,et al.  Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1. , 1991, Mutation research.

[96]  T. Arinami,et al.  Replication patterns of the fragile X in heterozygous carriers: analysis by a BrdUrd antibody method. , 1990, American journal of human genetics.

[97]  Wei-dong Yu,et al.  X chromosome imprinting in fragile×syndrome , 1990, Human Genetics.

[98]  J. DiPaolo,et al.  Preferential sites for viral integration on mammalian genome. , 1989, Cancer genetics and cytogenetics.

[99]  T. J. Robinson,et al.  Rodent common fragile sites: Are they conserved? Evidence from mouse and rat , 1989, Chromosoma.

[100]  T. Glover,et al.  Chromosome breakage and recombination at fragile sites. , 1988, American journal of human genetics.

[101]  F. Hecht.  Fragile sites, cancer chromosome breakpoints, and oncogenes all cluster in light G bands. , 1988, Cancer genetics and cytogenetics.

[102]  R. Painter,et al.  A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication. , 1988, Mutation research.

[103]  T. Glover,et al.  Induction of sister chromatid exchanges at common fragile sites. , 1987, American journal of human genetics.

[104]  R. Schlegel,et al.  Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. , 1986, Science.

[105]  J. Yunis,et al.  Constitutive fragile sites and cancer. , 1984, Science.

[106]  F. Hecht,et al.  Fragile sites and cancer breakpoints. , 1984, Cancer genetics and cytogenetics.

[107]  J. de Grouchy,et al.  A cytogenetic survey of 110 baboons (Papio cynocephalus). , 1981, American journal of physical anthropology.

[108]  S. Jacobs,et al.  Hereditary renal-cell carcinoma associated with a chromosomal translocation. , 1979, The New England journal of medicine.

[109]  T. Taguchi,et al.  Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α , 1978, Nature.

[110]  T. Glover,et al.  DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes , 2004, Human Genetics.

[111]  R. Hansen,et al.  Analysis of replication timing at the FRA10B and FRA16B fragile site loci , 2004, Chromosome Research.

[112]  A. Ruiz-Herrera,et al.  Conservation of aphidicolin-induced fragile sites in Papionini (Primates) species and humans , 2004, Chromosome Research.

[113]  S. Schreiber,et al.  Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints , 1998, The EMBO journal.

[114]  C. Croce,et al.  FHIT in human cancer. , 1998, Advances in cancer research.

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[116]  F. Toledo,et al.  Gene amplification mechanisms: the role of fragile sites. , 1998, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[117]  D. Smeets,et al.  Common fragile sites in man and three closely related primate species. , 1990, Cytogenetics and cell genetics.

[118]  T. Glover,et al.  Fragile sites: overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression. , 1986, Cancer genetics and cytogenetics.

[119]  R. Richards,et al.  Cancer and Dna Instability in Fra16d Chromosomal Fragile Site Updated Version Cited Articles Citing Articles E-mail Alerts Chromosomal Fragile Site Fra16d and Dna Instability in Cancer 1 , 2022 .

[120]  D. Schild,et al.  Mutants of the Five Rad51 Paralogs Recombinational Repair in Knockout Chromosome Instability and Defective , 2022 .