Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle.

[1]  A. Goldberg.  PROTEIN SYNTHESIS DURING WORK-INDUCED GROWTH OF SKELETAL MUSCLE , 1968, The Journal of cell biology.

[2]  A. Goldberg,et al.  Mechanism of work-induced hypertrophy of skeletal muscle. , 1975, Medicine and science in sports.

[3]  D. Goldspink,et al.  The influence of immobilization and stretch on protein turnover of rat skeletal muscle. , 1977, The Journal of physiology.

[4]  H. Vandenburgh,et al.  Stretch‐induced growth of skeletal myotubes correlates with activation of the sodium pump , 1981, Journal of cellular physiology.

[5]  V. Hh.  Motion into mass: how does tension stimulate muscle growth? , 1987 .

[6]  M. Clark,et al.  Exercise-induced translocation of protein kinase C and production of diacylglycerol and phosphatidic acid in rat skeletal muscle in vivo. Relationship to changes in glucose transport. , 1989, The Journal of biological chemistry.

[7]  H. Vandenburgh,et al.  Stretch-induced prostaglandins and protein turnover in cultured skeletal muscle. , 1990, The American journal of physiology.

[8]  H. Lane,et al.  p70s6k function is essential for G1 progression , 1993, Nature.

[9]  J. Heitman,et al.  TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin (*) , 1995, The Journal of Biological Chemistry.

[10]  S. Schreiber,et al.  Control of p70 S6 kinase by kinase activity of FRAP in vivo , 1995, Nature.

[11]  M. Wakelam,et al.  The measurement of phospholipase D-linked signaling in cells. , 1995, Methods in molecular biology.

[12]  F. Haddad,et al.  The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy. , 1996, Journal of applied physiology.

[13]  M. Kai,et al.  Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase* , 1997, The Journal of Biological Chemistry.

[14]  T. Kodaki,et al.  Cloning, Expression, and Characterization of a Novel Phospholipase D Complementary DNA from Rat Brain* , 1997, The Journal of Biological Chemistry.

[15]  K. Nair,et al.  Age-related sarcopenia in humans is associated with reduced synthetic rates of specific muscle proteins. , 1998, The Journal of nutrition.

[16]  M. M. Facchinetti,et al.  Calcitriol transmembrane signalling: regulation of rat muscle phospholipase D activity. , 1998, Journal of lipid research.

[17]  G. Adams,et al.  Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. , 1998, Journal of applied physiology.

[18]  Stefano Fumagalli,et al.  Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.

[19]  T. Kodaki,et al.  Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver. , 1998, The Biochemical journal.

[20]  S. Kritchevsky,et al.  Research hypotheses on muscle wasting, aging, loss of function and disability. , 1998, The journal of nutrition, health & aging.

[21]  K. Lynch,et al.  Identification of a novel human phosphatidic acid phosphatase type 2 isoform , 1998, FEBS letters.

[22]  H. Vandenburgh,et al.  Space travel directly induces skeletal muscle atrophy , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  K. Esser,et al.  Phosphorylation of p70S6kcorrelates with increased skeletal muscle mass following resistance exercise. , 1999, American journal of physiology. Cell physiology.

[24]  L. Shantz,et al.  Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6* , 1999, The Journal of Biological Chemistry.

[25]  R. Fitts,et al.  Physiology of a microgravity environment invited review: microgravity and skeletal muscle. , 2000, Journal of applied physiology.

[26]  O. Meyuhas.  Synthesis of the translational apparatus is regulated at the translational level. , 2000, European journal of biochemistry.

[27]  S B Heymsfield,et al.  Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. , 2000, The American journal of clinical nutrition.

[28]  Jie Chen,et al.  Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling , 2001, Science.

[29]  D. A. Foster,et al.  Role for Phospholipase D in Receptor-Mediated Endocytosis , 2001, Molecular and Cellular Biology.

[30]  G. Yancopoulos,et al.  Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo , 2001, Nature Cell Biology.

[31]  S. Gordon,et al.  Time course of the MAPK and PI3-kinase response within 24 h of skeletal muscle overload. , 2001, Journal of applied physiology.

[32]  S. Bonavaud,et al.  Regulation of Glycogen Synthesis by Amino Acids in Cultured Human Muscle Cells* , 2001, The Journal of Biological Chemistry.

[33]  C. Rommel,et al.  Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways , 2001, Nature Cell Biology.

[34]  Eric P Hoffman,et al.  Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling , 2002, The Journal of physiology.

[35]  J. Blenis,et al.  Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. , 2002, Genes & development.

[36]  E. Calabria,et al.  A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[37]  S. Kimball,et al.  highlighted topics Exercise Effects on Muscle Insulin Signaling and Action Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise , 2002 .

[38]  A. Ball,et al.  Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. , 2003, Molecular cancer therapeutics.

[39]  K. Esser,et al.  Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth. , 2003, The Journal of nutrition.

[40]  L. Goodyear,et al.  AMP-activated protein kinase regulation and action in skeletal muscle during exercise. , 2001, Biochemical Society transactions.

[41]  M. Nanjundan,et al.  Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. , 2003, American journal of physiology. Lung cellular and molecular physiology.

[42]  L. Goodyear,et al.  Akt signaling in skeletal muscle: regulation by exercise and passive stretch. , 2003, American journal of physiology. Endocrinology and metabolism.

[43]  D. Williamson,et al.  Immediate Response of Mammalian Target of Rapamycin (mTOR)‐Mediated Signalling Following Acute Resistance Exercise in Rat Skeletal Muscle , 2003, The Journal of physiology.

[44]  D. A. Foster,et al.  Phospholipase D confers rapamycin resistance in human breast cancer cells , 2003, Oncogene.

[45]  M. Nelson,et al.  The benefits of strength training for older adults. , 2003, American journal of preventive medicine.

[46]  K. Inoki,et al.  Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. , 2003, Genes & development.

[47]  R. Liao,et al.  Deletion of cytosolic phospholipase A2 promotes striated muscle growth , 2003, Nature Medicine.

[48]  M. Hentze,et al.  Molecular mechanisms of translational control , 2004, Nature Reviews Molecular Cell Biology.

[49]  R. Loewith,et al.  Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.

[50]  Stefano Fumagalli,et al.  S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway , 2004, Molecular and Cellular Biology.

[51]  G. Cartee,et al.  Postcontraction insulin sensitivity: relationship with contraction protocol, glycogen concentration, and 5' AMP-activated protein kinase phosphorylation. , 2004, Journal of applied physiology.

[52]  K. Esser,et al.  Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. , 2004, The Biochemical journal.

[53]  J. Blenis,et al.  mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E , 2004, Molecular and Cellular Biology.

[54]  David A Foster,et al.  Alternative phospholipase D/mTOR survival signal in human breast cancer cells , 2005, Oncogene.

[55]  I. Mérida,et al.  Modulation of the Mammalian Target of Rapamycin Pathway by Diacylglycerol Kinase-produced Phosphatidic Acid* , 2005, Journal of Biological Chemistry.

[56]  G. Lienhard,et al.  Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity. , 2005, Diabetes.

[57]  G. Nader.  Molecular determinants of skeletal muscle mass: getting the "AKT" together. , 2005, The international journal of biochemistry & cell biology.

[58]  J. Avruch,et al.  Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency* , 2005, Journal of Biological Chemistry.

[59]  G. Jenkins,et al.  Phospholipase D: a lipid centric review , 2005, Cellular and Molecular Life Sciences CMLS.

[60]  N. Sonenberg,et al.  Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control , 2005, Nature Cell Biology.

[61]  J. Babraj,et al.  Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[62]  F. Natt,et al.  Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  G. Hatch,et al.  Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart , 2005 .

[64]  N. Sonenberg,et al.  Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity* , 2005, Journal of Biological Chemistry.

[65]  D. Bolster,et al.  Resistance Exercise Increases Muscle Protein Synthesis and Translation of Eukaryotic Initiation Factor 2Bϵ mRNA in a Mammalian Target of Rapamycin-dependent Manner* , 2005, Journal of Biological Chemistry.

[66]  E. Spangenburg,et al.  Inhibition of stretch-activated channels during eccentric muscle contraction attenuates p70S6K activation. , 2006, Journal of applied physiology.

[67]  D. Guertin,et al.  Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. , 2006, Developmental cell.

[68]  S. Kimball.  Interaction between the AMP-activated protein kinase and mTOR signaling pathways. , 2006, Medicine and science in sports and exercise.

[69]  M. Topham.  Signaling roles of diacylglycerol kinases , 2006, Journal of cellular biochemistry.

[70]  S. Jang,et al.  PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. , 2006, Cellular signalling.

[71]  S. Chien,et al.  The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[72]  A. Deshmukh,et al.  Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle , 2006, Diabetes.

[73]  F. Haddad,et al.  Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. , 2006, Journal of applied physiology.

[74]  S. Chien,et al.  Mechanical stimuli and nutrients regulate rapamycin‐sensitive signaling through distinct mechanisms in skeletal muscle , 2006, Journal of cellular biochemistry.

[75]  G. Carman,et al.  Roles of phosphatidate phosphatase enzymes in lipid metabolism. , 2006, Trends in biochemical sciences.

[76]  N. Lockhart,et al.  Activation of Akt as a potential mediator of adaptations that reduce muscle injury. , 2006, Medicine and science in sports and exercise.

[77]  Long Yu,et al.  Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. , 2006, Journal of biochemistry and molecular biology.

[78]  N. Fujii,et al.  AMP-activated protein kinase and the regulation of glucose transport. , 2006, American journal of physiology. Endocrinology and metabolism.

[79]  Wenhua Zhang,et al.  Signaling functions of phosphatidic acid. , 2006, Progress in lipid research.

[80]  D. Sabatini,et al.  Stress and mTORture signaling , 2006, Oncogene.

[81]  J. Avruch,et al.  Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase , 2006, Oncogene.

[82]  K. Guan,et al.  Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? , 2006, Oncogene.

[83]  G. Thomas,et al.  Nutrient sensing in the mTOR/S6K1 signalling pathway. , 2007, Biochemical Society transactions.

[84]  T. Okumura,et al.  A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells. , 2007, Biochemical and biophysical research communications.

[85]  C. Lang,et al.  Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass. , 2007, Journal of applied physiology.

[86]  R. Khandelwal,et al.  Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70(S6K) in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB. , 2007, Biochimica et biophysica acta.

[87]  J. Shabanowitz,et al.  Insulin Controls Subcellular Localization and Multisite Phosphorylation of the Phosphatidic Acid Phosphatase, Lipin 1* , 2007, Journal of Biological Chemistry.

[88]  M. Kai,et al.  Diacylglycerol kinases: why so many of them? , 2007, Biochimica et biophysica acta.

[89]  K. Guan,et al.  Expanding mTOR signaling , 2007, Cell Research.

[90]  H. Arai,et al.  Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family. , 2007, Biochimie.

[91]  K. Jakobs,et al.  Dynamic phospholipid signaling by G protein-coupled receptors. , 2007, Biochimica et biophysica acta.

[92]  X. Bai,et al.  Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38 , 2007, Science.

[93]  C. Proud.  Signalling to translation: how signal transduction pathways control the protein synthetic machinery. , 2007, The Biochemical journal.

[94]  D. A. Foster,et al.  Regulation of mTOR by phosphatidic acid? , 2007, Cancer Research.

[95]  S. Chien,et al.  mTOR is the rapamycin‐sensitive kinase that confers mechanically‐induced phosphorylation of the hydrophobic motif site Thr(389) in p70S6k , 2007, FEBS letters.

[96]  M. Carr,et al.  Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR , 2008, Oncogene.

[97]  Marco Sandri,et al.  Signaling in muscle atrophy and hypertrophy. , 2008, Physiology.

[98]  X. Bai,et al.  The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38* , 2008, Journal of Biological Chemistry.

[99]  T. P. Neufeld,et al.  The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila , 2008, The Journal of cell biology.

[100]  B. Manning,et al.  The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. , 2008, The Biochemical journal.

[101]  F. Natt,et al.  Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. , 2008, Cell metabolism.

[102]  T. P. Neufeld,et al.  Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.

[103]  C. Ward,et al.  A functional insulin‐like growth factor receptor is not necessary for load‐induced skeletal muscle hypertrophy , 2008, The Journal of physiology.

[104]  David M. Sabatini,et al.  The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.

[105]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[106]  H. A. Brown,et al.  Phospholipase D1 is an effector of Rheb in the mTOR pathway , 2008, Proceedings of the National Academy of Sciences.

[107]  N. LeBrasseur,et al.  Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. , 2008, Cell metabolism.

[108]  E. Volpi,et al.  Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis , 2009, The Journal of physiology.

[109]  P. M. Taylor,et al.  mVps34 is activated following high‐resistance contractions , 2009, The Journal of physiology.

[110]  Haiyan Wu,et al.  hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells , 2008, The Biochemical journal.

[111]  J. Blenis,et al.  Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. , 2009, Progress in molecular biology and translational science.

[112]  J. Avruch,et al.  Amino acid regulation of TOR complex 1. , 2009, American journal of physiology. Endocrinology and metabolism.

[113]  T. Hornberger,et al.  The role of phosphoinositide 3‐kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions , 2009, The Journal of physiology.

[114]  K. Guan,et al.  RAG GTPases in nutrient-mediated TOR signaling pathway , 2009, Cell cycle.

[115]  M. Gelb,et al.  5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis , 2009, Molecular Pharmacology.

[116]  D. Sabatini,et al.  Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids , 2010, Cell.

[117]  T. Hornberger,et al.  A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy , 2010, Molecular biology of the cell.

[118]  T. Hornberger,et al.  A PI3K/PKB-Independent Activation of mTOR Signaling is Sufficient to Induce Skeletal Muscle Hypertrophy , 2010 .

[119]  M. Kester,et al.  Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. , 2010, American journal of physiology. Cell physiology.

[120]  Philippe Pierre,et al.  Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.