Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.

[1]  D. Jain,et al.  Liver disease in patients with hereditary hemorrhagic telangiectasia. , 2000, The New England journal of medicine.

[2]  N. Pece-Barbara,et al.  Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2. , 2000, Human molecular genetics.

[3]  R. D'Amato,et al.  Genetic heterogeneity of angiogenesis in mice , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  P. Donahoe,et al.  Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Guttmacher,et al.  Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). , 2000, American journal of medical genetics.

[6]  A. Guttmacher,et al.  Endoglin expression is reduced in normal vessels but still detectable in arteriovenous malformations of patients with hereditary hemorrhagic telangiectasia type 1. , 2000, The American journal of pathology.

[7]  D. Dumont,et al.  A murine model of hereditary hemorrhagic telangiectasia. , 1999, The Journal of clinical investigation.

[8]  D. Marchuk,et al.  Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1. , 1999, Human molecular genetics.

[9]  J. Sheehan,et al.  Factors associated with hydrocephalus after aneurysmal subarachnoid hemorrhage. , 1999, Neurosurgery.

[10]  P. Lastres,et al.  Endoglin overexpression modulates cellular morphology, migration, and adhesion of mouse fibroblasts. , 1999, European journal of cell biology.

[11]  C. Shovlin,et al.  Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms , 1999, Thorax.

[12]  E. Kanal,et al.  Development of obstructive hydrocephalus with lumboperitoneal shunting following subarachnoid hemorrhage , 1999, Clinical Neurology and Neurosurgery.

[13]  B. Brooke,et al.  Defective angiogenesis in mice lacking endoglin. , 1999, Science.

[14]  M. Matzuk,et al.  Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. , 1999, Development.

[15]  J. Wrana,et al.  Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily* , 1999, The Journal of Biological Chemistry.

[16]  A. Roberts Molecular and Cell Biology of TGF-β , 1998, Mineral and Electrolyte Metabolism.

[17]  J. Wrana,et al.  Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative. , 1997, The Journal of clinical investigation.

[18]  J. Hughes,et al.  Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. , 1997, American journal of human genetics.

[19]  M. Farrall,et al.  Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice , 1997, Nature Genetics.

[20]  J. Folkman,et al.  Blood Vessel Formation: What Is Its Molecular Basis? , 1996, Cell.

[21]  M. Taketo,et al.  TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. , 1996, Developmental biology.

[22]  P. Lastres,et al.  Endoglin modulates cellular responses to TGF-beta 1 , 1996, The Journal of cell biology.

[23]  D. W. Johnson,et al.  Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2 , 1996, Nature Genetics.

[24]  A. Guttmacher,et al.  Clinical heterogeneity in hereditary haemorrhagic telangiectasia: are pulmonary arteriovenous malformations more common in families linked to endoglin? , 1996, Journal of medical genetics.

[25]  J. Hughes,et al.  Medical complications of pregnancy in hereditary haemorrhagic telangiectasia. , 1995, QJM : monthly journal of the Association of Physicians.

[26]  A. Kulkarni,et al.  Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. , 1995, Development.

[27]  Y. Ikegami,et al.  Central nervous system arteriovenous malformations with hereditary hemorrhagic telangiectasia: report of a family with three cases. , 1994, Surgical neurology.

[28]  M. Kowada,et al.  Vascular malformations of the brain in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease). , 1994, Surgical neurology.

[29]  B. Jacobson,et al.  Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia. , 1990, The Journal of investigative dermatology.

[30]  M. Sporn,et al.  Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex , 1990, Molecular and cellular biology.

[31]  P. Coulson,et al.  Portal shunting and resistance to Schistosoma mansoni in 129 strain mice , 1989, Parasitology.

[32]  D. McLaren,et al.  Schistosoma mansoni: evidence that vascular abnormalities correlate with the ‘non- permissive’ trait in 129/Ola mice , 1989, Parasitology.

[33]  H. Plauchu,et al.  Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population. , 1989, American journal of medical genetics.

[34]  P. Vase,et al.  Gastrointestinal lesions in hereditary hemorrhagic telangiectasia. , 1986, Gastroenterology.

[35]  I. Wanless,et al.  Nodular transformation of the liver in hereditary hemorrhagic telangiectasia. , 1986, Archives of pathology & laboratory medicine.

[36]  G. Martini The liver in hereditary haemorrhagic teleangiectasia: an inborn error of vascular structure with multiple manifestations: a reappraisal. , 1978, Gut.

[37]  K. E. Quickel,et al.  Subarachnoid hemorrhage in a patient with hereditary hemorrhagic telangiectasia , 1967, Neurology.

[38]  Robert I. White,et al.  Identification of Hereditary Hemorrhagic Telangiectasia Type 1 in Newborns by Protein Expression and Mutation Analysis of Endoglin , 2000, Pediatric Research.

[39]  D. Marchuk,et al.  Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. , 2000, Developmental biology.

[40]  L. Greiner,et al.  The liver in hereditary hemorrhagic telangiectasia (Weber-Rendu-Osler disease). , 1999, Scandinavian journal of gastroenterology.

[41]  S. Rossi,et al.  Hepatic vascular malformations in hereditary hemorrhagic telangiectasia: Doppler sonographic screening in a large family. , 1997, Journal of hepatology.

[42]  E. Schrumpf,et al.  Monstrous ascites in hereditary haemorrhagic telangiectasia. , 1995, Scandinavian journal of gastroenterology.

[43]  D. W. Johnson,et al.  Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1 , 1994, Nature Genetics.