Isosterism and molecular modification in drug design: tetrazole analogue of GABA: effects on enzymes of the gamma-aminobutyrate system.

Summary The tetrazole analogue of GABA (γ-aminobutyric acid) has been tested for activity in the γ-aminobutyric-glutamic transaminase and succinic semialdehyde dehydrogenase system from Pseudomonas fluorescens. This analogue was found without activity as substrate but with a specific inhibitory action on the γ-aminobutyric-glutamic transaminase.