In the context of an increased globalisation of sales and procurement markets companies are distributing their manufacturing activities in global networks. A key challenge is to ensure the overall production quality despite distributed value creation processes in complex manufacturing networks. Hence, a simulation model is presented, which allows for an evaluation of quality control strategies in global manufacturing networks. Based on the approach of Value Stream Mapping (VSM), which is enhanced by quality-relevant elements, a simulation approach is developed to dynamically evaluate different quality control strategies taking the individual target systems and site roles of the involved partners in the manufacturing network into account.