Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices

Asthma presents as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyper‐reactivity (AHR). Spleen tyrosine kinase (Syk) mediates allergen‐induced mast cell degranulation, a central component of allergen‐induced inflammation and AHR. However, the role of Syk in IgE‐mediated constriction of human small airways remains unknown. In this study, we addressed whether selective inhibition of Syk attenuates IgE‐mediated constriction and mast cell mediator release in human small airways.

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