Molecular approaches to neural coding.

Information processing in the nervous system is based essentially on the existence of highly organized specific connections. While innate information is coded in terms of prewired circuits, learned information probably involves the creation of new connections between the existing pathways to establish an acquired circuit, representing the memory trace. The persistence of these circuits can be best explained by the formation of specific molecular markers. One of these coded substances has been isolated, identified as a pentadecapeptide and reproduced by synthesis.

[1]  Georges Ungar,et al.  Molecular Mechanisms in Information Processing1 , 1970 .

[2]  E. Kandel,et al.  Cellular neurophysiological approaches in the study of learning. , 1968, Physiological reviews.

[3]  G. Ungar,et al.  Transfer of Habituation by Material extracted from Brain , 1965, Nature.

[4]  G. Brindley.  The classification of modifiable synapses and their use in models for conditioning , 1967, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[5]  Georges Ungar,et al.  Chemical Transfer of Acquired Information , 1971 .

[6]  B. Cragg,et al.  Are there structural alterations in synapses related to functioning? , 1968, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[7]  L. B. Flexner,et al.  A model for the development of retina-cortex connections. , 1966, American Scientist.

[8]  John C. Eccles,et al.  Conscious Experience and Memory , 1966 .

[9]  G. Ungar,et al.  Chemical Nature of the Transfer Factors; RNA or Protein? , 1971 .

[10]  G. Ungar,et al.  Chemical Transfer of Learned Fear , 1968, Nature.

[11]  W R Uttal,et al.  Emerging Principles of Sensory Coding , 2015, Perspectives in biology and medicine.

[12]  L. Szilard,et al.  ON MEMORY AND RECALL. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Jacobson,et al.  Development of specific neuronal connections. , 1969, Science.

[14]  N. RafaelLorenteDe,et al.  ANALYSIS OF THE ACTIVITY OF THE CHAINS OF INTERNUNCIAL NEURONS , 1938 .

[15]  Gardner-Medwin Ar,et al.  Modifiable synapses necessary for learning. , 1969 .

[16]  R M Best,et al.  Encoding of Memory in the Neuron , 1968, Psychological reports.

[17]  R. Sperry.  CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[18]  T. Landauer.  TWO HYPOTHESES CONCERNING THE BIOCHEMICAL BASIS OF MEMORY. , 1964, Psychological review.

[19]  E. Glassman,et al.  The biochemistry of learning: an evaluation of the role of RNA and protein. , 1969, Annual review of biochemistry.

[20]  Wolfgang Parr,et al.  Synthesen von Scotophobin-Analoga. Peptide mit gedächtnisübertragender Wirkung , 1971 .

[21]  David A. Booth,et al.  Neurochemical changes correlated with learning and memory retention , 1970 .

[22]  G Ungar,et al.  Molecular Mechanisms in Learning , 2015, Perspectives in biology and medicine.

[23]  P. Carbone,et al.  Inhibition of Adhesiveness and Aggregation of Dissociated Cells by Inhibitors of Protein and RNA Synthesis , 1963, Science.

[24]  G. Ungar,et al.  The use of mass spectrometry in the structural elucidation of scotophobin–A specific behaviour-inducing brain peptide , 1971 .

[25]  G Chapouthier,et al.  Mécanismes moléculaires de l'utilisation de l'information par le cerveau , 1971 .

[26]  H. Hydén,et al.  Behavior, neural function, and RNA. , 1967, Progress in nucleic acid research and molecular biology.

[27]  C. Sherrington.  Integrative Action of the Nervous System , 1907 .

[28]  G. Ungar,et al.  Isolation, Identification and Synthesis of a specific-behaviour-inducing Brain Peptide , 1972, Nature.