Stereoselective Synthesis of 4H‐5,6‐Dihydro‐1,3‐thiazines by the Reaction of 3‐N‐Acylamino Alcohols with Lawesson’s Reagent

The 4H-5,6-Dihydro-1,3-thiazine derivatives 13−15 were obtained exclusively and stereoselectively in fair yields by treating the 3-N-acylamino alcohols 5−8 with an equimolar amount of Lawesson’s reagent (LR), while the corresponding thiols 9−12 were afforded stereoselectively when only 0.5 equiv. of LR was used in this reaction.

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