Barriers and facilitators to enrollment in cancer clinical trials

The literature continues to report low rates of accrual to cancer clinical trials. Previous studies have examined principally physician‐related or patient‐related barriers. Clinical research associates (CRAs) have a unique perspective on enrollment that has been explored very little. This study sought the views of CRAs on barriers and facilitators to accrual.

[1]  D. Gandara,et al.  Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  Herbert Snyder,et al.  Qualitative interviewing: The art of hearing data , 1996 .

[3]  C. Gotay,et al.  Accrual to cancer clinical trials: directions from the research literature. , 1991, Social science & medicine.

[4]  R. Prescott,et al.  Barriers to participation in randomised controlled trials: a systematic review. , 1999, Journal of clinical epidemiology.

[5]  R. Souhami,et al.  Clinicians' attitudes to clinical trials of cancer therapy. , 1997, European journal of cancer.

[6]  N Colabianchi,et al.  Factors that predict the referral of breast cancer patients onto clinical trials by their surgeons and medical oncologists. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  A. Bowling,et al.  Volunteers or victims: patients' views of randomised cancer clinical trials. , 1995, British Journal of Cancer.

[8]  C. Moertel,et al.  Improving accrual into cancer clinical trials. , 1991, Journal of cancer education : the official journal of the American Association for Cancer Education.

[9]  Winn Rj,et al.  Obstacles to the accrual of patients to clinical trials in the community setting. , 1994 .

[10]  A. Strauss,et al.  The Discovery of Grounded Theory , 1967 .

[11]  M. Aitken,et al.  Why don't cancer patients get entered into clinical trials? Experience of the Sheffield Lymphoma Group's collaboration in British National Lymphoma Investigation studies , 1997, BMJ.

[12]  D. Mayer,et al.  Obstacles to implementing cancer clinical trials. , 1991, Seminars in oncology nursing.

[13]  P. Butow,et al.  Randomized clinical trials in oncology: understanding and attitudes predict willingness to participate. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  J. Tangrea.  Patient Participation and Compliance in Cancer Chemoprevention Trials: Issues and Concerns , 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[15]  Steven Joffe,et al.  Quality of informed consent in cancer clinical trials: a cross-sectional survey , 2001, The Lancet.

[16]  G. Swanson,et al.  Recruiting minorities into clinical trials: toward a participant-friendly system. , 1995, Journal of the National Cancer Institute.

[17]  R. Winn,et al.  Obstacles to the accrual of patients to clinical trials in the community setting. , 1994, Seminars in oncology.