Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis

Levels of alkaline phosphatase were measured in the primary tumor of 26 patients with osteosarcoma. One of seven patients with a tissue alkaline phosphatase level less than 0.6 μM/min/mg developed pulmonary metastases. In contrast, 16 of 17 patients with a tissue alkaline phosphatase level greater than 0.6 μM/min/mg developed pulmonary metastases. It thus appears that tissue alkaline phosphatase levels of primary osteosarcomas are strongly correlated with prognosis (p < .01).

[1]  D. Dahlin.  Prognostic factors in osteosarcoma. , 1980, International journal of radiation oncology, biology, physics.

[2]  C. Rutherford,et al.  A microchemical analysis of alkaline phosphatase in human malignant and benign breast tumours , 1977, International journal of cancer.

[3]  T. Martin,et al.  Radiation induced osteogenic sarcoma in the rat as a model of hormone-responsive differentiated cancer. , 1977, Laboratory animal science.

[4]  D. C. Hurst,et al.  An experimental approach to relate a tumor-associated enzyme marker to tumor cell numbers. , 1977, Cancer research.

[5]  R. Hiramoto,et al.  Monitoring of murine osteosarcoma by serial alkaline phosphatase determinations. , 1976, Journal of the National Cancer Institute.

[6]  P. Scranton,et al.  Prognostic factors in osteosarcoma: A review of 20 years' experience at the university of pittsburgh health center hospitals , 1975 .

[7]  K. Tsang,et al.  An in vitro production of bone specific alkaline phosphatase. , 1975, Experimental cell research.

[8]  H. Miki,et al.  Osteogenic sarcoma. A study of one hundred and thirty cases. , 1975, The Journal of bone and joint surgery. American volume.

[9]  M. Bakowski,et al.  The biochemical activity of fracture callus in relation to bone production. , 1975, Clinical orthopaedics and related research.

[10]  L. Ewen.  Separation of alkaline phosphatase isoenzymes and evaluation of the clinical usefulness of this determination. , 1974, American journal of clinical pathology.

[11]  B. Skrovina,et al.  Biochemical and haematological findings in malignant bone tumours. , 1974, Neoplasma.

[12]  D. Rowe,et al.  Electrophoretic separation of tissue-specific serum alkaline phosphatases , 1970, Journal of clinical pathology.

[13]  H. Woodard,et al.  An analysis of thirty patients surviving longer than ten years after treatment for osteogenic sarcoma. , 1968, The Journal of bone and joint surgery. American volume.

[14]  C. P. Schwinn,et al.  SARCOMATA OF THE OSTEOGENIC SERIES (OSTEOSARCOMA, FIBROSARCOMA, CHONDROSARCOMA, PAROSTEAL OSTEOGENIC SARCOMA, AND SARCOMATA ARISING IN ABNORMAL BONE). AN ANALYSIS OF 552 CASES. , 1966 .

[15]  O. H. Lowry,et al.  The quantitative histochemistry of the retina. , 1956, The Journal of biological chemistry.

[16]  O. H. Lowry,et al.  The quantitative histochemistry of brain. II. Enzyme measurements. , 1954, The Journal of biological chemistry.

[17]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[18]  L. Clark,et al.  Plasma “alkaline” phosphatase activity , 1950 .