Hepatic extraction of exogenous insulin and glucagon in the dog.

Insulin and glucagon were infused simultaneously into anesthetized mongrel dogs in order to assess whether exogenous hormone administration would affect the hepatic extraction of insulin (E1) and/or glucagon (EGG). During an equilibration period and a subsequent control period, saline was infused into the portal circulation via the caudal pancreaticoduodenal artery. Blood samples for insulin, glucagon, and glucose were obtained frequently during the 30-min control period from the portal vein, left common hepatic vein, and femoral artery. Plasma flows were measured in the portal vein and hepatic artery. Then the saline infusion was replaced by insulin (0.035 U/min) and glucagon (0.32 μg/min) which were infused together over a period of 50 min. This caused an 8-fold increase in the portal vein insulin concentration and a 15-fold increase in the corresponding glucagon concentration. E1 decreased significantly during the infusion from a control value of 63 ± 5% to a nadir of 18 ± 8% (P < 0.001). It returned t...

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