The feasibility of maximum length sequences to reduce acquisition time of the middle latency response.

Maximum length sequences (MLS) have been used to improve the signal-to-noise ratio (SNR) of otoacoustic emissions [Thornton, J. Acoust. Soc. Am. 94, 132-136 (1993)] and the auditory brainstem response [Thornton and Slaven, Br. J. Audiol. 27, 205-210 (1993)]. By implication, a shorter recording time would be required to give equal signal-to-noise ratio (SNR). This study aimed to establish whether it is also possible to improve the SNR of the auditory-evoked potential termed the middle latency response (MLR) using maximum length sequences (MLS). Recordings of 180 s each were made using a conventional recording rate and MLS rates of 42, 89, and 185 clicks/s. Three different stimulus intensities were used in the range 30 to 70 dB nHL. The rate of 89 clicks/s was found to produce most improvement in SNR for both the Na-Pa region of the MLR and the Na-Pb region. This improvement in SNR using MLS implies that an MLS rate of 89 clicks/s would produce a fourfold reduction in recording time for equal SNR over conventional recording for the Pa-Nb region of the MLR at a stimulus intensity of 70 dB nHL. The latency of the Nb wave was found to reduce significantly using MLS. An MLR could not be recorded from every subject in this study, but more subjects had an identifiable response for MLS than for conventional recordings. Use of MLS to record the MLR appears to offer the potential for reduction in test time and better wave identification.

[1]  B. V. Veen,et al.  A framework for assessing the relative efficiency of stimulus sequences in evoked response measurements. , 1994, The Journal of the Acoustical Society of America.

[2]  S Cerutti,et al.  Analysis of visual evoked potentials through Wiener filtering applied to a small number of sweeps. , 1987, Journal of biomedical engineering.

[3]  R. Burkard Human brain-stem auditory evoked responses obtained by cross correlation to trains of clicks, noise bursts, and tone bursts. , 1991, The Journal of the Acoustical Society of America.

[4]  U Eysholdt,et al.  Maximum length sequences -- a fast method for measuring brain-stem-evoked responses. , 1982, Audiology : official organ of the International Society of Audiology.

[5]  H. Mantzaridis,et al.  Effects of cardiopulmonary bypass and hypothermia on electroencephalographic variables , 1997, Anaesthesia.

[6]  J. Jones,et al.  Evaluation of the actions of general anaesthetics in the human brain. , 1992, General pharmacology.

[7]  Derek A. Linkens,et al.  Intelligent signal processing of evoked potentials for anaesthesia monitoring and control , 1997 .

[8]  L. Collet,et al.  Auditory-evoked brainstem responses elicited by maximum-length sequences in normal and sensorineural ears. , 1994, Audiology : official organ of the International Society of Audiology.

[9]  A. Wilkinson,et al.  Brainstem Auditory Evoked Response Recorded Using Maximum Length Sequences in Term Neonates , 1999, Neonatology.

[10]  G N Kenny,et al.  Auditory evoked potential index: a quantitative measure of changes in auditory evoked potentials during general anaesthesia , 1997, Anaesthesia.

[11]  F. Musiek,et al.  Conventional and maximum length sequences middle latency response in patients with central nervous system lesions. , 1997, Journal of the American Academy of Audiology.

[12]  T W Picton,et al.  Human auditory evoked potentials recorded using maximum length sequences. , 1992, Electroencephalography and clinical neurophysiology.

[13]  R. Bickford,et al.  Brain stem auditory evoked potentials: the use of noise estimate. , 1980, Electroencephalography and clinical neurophysiology.

[14]  K E Hecox,et al.  Brain-stem auditory-evoked responses elicited by maximum length sequences: effect of simultaneous masking noise. , 1990, The Journal of the Acoustical Society of America.

[15]  A R Thornton,et al.  High rate otoacoustic emissions. , 1993, The Journal of the Acoustical Society of America.

[16]  R. Lasky,et al.  Binaural maximum length sequence auditory-evoked brain-stem responses in human adults. , 1993, The Journal of the Acoustical Society of America.

[17]  P J Cluitmans,et al.  Midlatency auditory evoked potentials as indicators of perceptual processing during general anaesthesia. , 1996, British journal of anaesthesia.

[18]  C Thornton,et al.  Evoked potentials in anaesthesia. , 1991, European journal of anaesthesiology.

[19]  A R Thornton,et al.  Auditory brainstem responses recorded at fast stimulation rates using maximum length sequences. , 1993, British journal of audiology.

[20]  T. Heier,et al.  Assessment of anaesthesia depth , 1996, Acta anaesthesiologica Scandinavica.

[21]  G N Kenny,et al.  Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. , 1998, British journal of anaesthesia.