The SR protein family of splicing factors: master regulators of gene expression.
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[1] A. Lamond,et al. Spatial mapping of splicing factor complexes involved in exon and intron definition , 2008, The Journal of cell biology.
[2] J. Ellenberg,et al. FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35. , 2005, RNA.
[3] D. Barton,et al. The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding. , 1987, Nucleic acids research.
[4] The role of U2AF35 and U2AF65 in enhancer-dependent splicing. , 2001, RNA.
[5] P. Sharp,et al. A coactivator of pre-mRNA splicing. , 1998, Genes & development.
[6] Jinhua Wang,et al. ESEfinder: a web resource to identify exonic splicing enhancers , 2003, Nucleic Acids Res..
[7] Adrian R. Krainer,et al. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2 , 1992, Cell.
[8] Xiang-Dong Fu,et al. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. , 2005, Molecular cell.
[9] A. Krainer,et al. Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. , 2001, RNA.
[10] A. Krainer,et al. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. , 1998, Genes & development.
[11] K. Scotto,et al. Caffeine Regulates Alternative Splicing in a Subset of Cancer-Associated Genes: a Role for SC35 , 2007, Molecular and Cellular Biology.
[12] J. Tazi,et al. Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I , 1996, Nature.
[13] M. Mckeown,et al. Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene , 1987, Cell.
[14] C. Burd,et al. hnRNP proteins and the biogenesis of mRNA. , 1993, Annual review of biochemistry.
[15] Francisco E. Baralle,et al. Regulation of Fibronectin EDA Exon Alternative Splicing: Possible Role of RNA Secondary Structure for Enhancer Display , 1999, Molecular and Cellular Biology.
[16] A. Kornblihtt. Coupling transcription and alternative splicing. , 2007, Advances in experimental medicine and biology.
[17] Xiang-Dong Fu,et al. SR proteins and related factors in alternative splicing. , 2007, Advances in experimental medicine and biology.
[18] A. Krainer,et al. Selection of Alternative 5′ Splice Sites: Role of U1 snRNP and Models for the Antagonistic Effects of SF2/ASF and hnRNP A1 , 2000, Molecular and Cellular Biology.
[19] A. Krainer,et al. Involvement of SR proteins in mRNA surveillance. , 2004, Molecular cell.
[20] N. Gray,et al. A novel role for shuttling SR proteins in mRNA translation. , 2004, Genes & development.
[21] A. Krainer,et al. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. , 1994, Science.
[22] M. Wener,et al. SR proteins are autoantigens in patients with systemic lupus erythematosus. Importance of phosphoepitopes. , 2000, Arthritis and rheumatism.
[23] J. Tazi,et al. Small-Molecule Inhibition of HIV pre-mRNA Splicing as a Novel Antiretroviral Therapy to Overcome Drug Resistance , 2007, PLoS pathogens.
[24] G. Akusjärvi,et al. The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection. , 2004, The Biochemical journal.
[25] J. Tazi,et al. Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing , 1993, Nature.
[26] J. Manley,et al. A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy , 2003, Nature Genetics.
[27] J. Manley,et al. The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. , 2007, RNA.
[28] B. Semler,et al. A nucleo‐cytoplasmic SR protein functions in viral IRES‐mediated translation initiation , 2007, The EMBO journal.
[29] T. Maniatis,et al. Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. , 1996, Genes & development.
[30] J. Manley,et al. A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro , 1990, Cell.
[31] E. Buratti,et al. SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer , 2007, Nucleic acids research.
[32] Jernej Ule,et al. CLIP Identifies Nova-Regulated RNA Networks in the Brain , 2003, Science.
[33] Gene W. Yeo,et al. A regulator of Dscam mutually exclusive splicing fidelity , 2007, Nature Structural &Molecular Biology.
[34] L. Chasin,et al. Computational definition of sequence motifs governing constitutive exon splicing. , 2004, Genes & development.
[35] Dirk G Kieback,et al. Expression of splicing factors in human ovarian cancer. , 2004, Oncology reports.
[36] Eric Verdin,et al. Reduced Mobility of the Alternate Splicing Factor (Asf) through the Nucleoplasm and Steady State Speckle Compartments , 2000, The Journal of cell biology.
[37] H. Amrein,et al. The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein , 1988, Cell.
[38] M. Gabut,et al. The SR Protein SC35 Is Responsible for Aberrant Splicing of the E1α Pyruvate Dehydrogenase mRNA in a Case of Mental Retardation with Lactic Acidosis , 2005, Molecular and Cellular Biology.
[39] H. Jumaa,et al. Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20 , 1999, Current Biology.
[40] J. E. Mermoud,et al. Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. , 1994, The EMBO journal.
[41] C. Stoltzfus,et al. Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicing. , 2006, Current HIV research.
[42] A. Zahler,et al. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer , 1995, Molecular and cellular biology.
[43] S. Stamm,et al. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. , 1997, DNA and cell biology.
[44] S. Niranjanakumari,et al. Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. , 2002, Methods.
[45] Michael R Green,et al. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. , 2005, Molecular cell.
[46] E. Birney,et al. Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. , 1993, Nucleic acids research.
[47] J. Lis,et al. A specific RNA hairpin loop structure binds the RNA recognition motifs of the Drosophila SR protein B52 , 1997, Molecular and cellular biology.
[48] Steven P. Gygi,et al. Comprehensive proteomic analysis of the human spliceosome , 2002, Nature.
[49] J. Ross,et al. Dilated cardiomyopathy caused by tissue‐specific ablation of SC35 in the heart , 2004, The EMBO journal.
[50] T. Maniatis,et al. Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[51] B. Blencowe,et al. SR-related proteins and the processing of messenger RNA precursors. , 1999, Biochemistry and cell biology = Biochimie et biologie cellulaire.
[52] A. Krainer,et al. The gene encoding the splicing factor SF2/ASF is a proto-oncogene , 2007, Nature Structural &Molecular Biology.
[53] B. Blencowe,et al. Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. , 2003, Genes & development.
[54] J. Castle,et al. Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays , 2003, Science.
[55] Xiang-Dong Fu,et al. Splicing Regulator SC35 Is Essential for Genomic Stability and Cell Proliferation during Mammalian Organogenesis , 2007, Molecular and Cellular Biology.
[56] J. Steitz,et al. A molecular link between SR protein dephosphorylation and mRNA export. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[57] H. Urlaub,et al. Isolation of an active step I spliceosome and composition of its RNP core , 2008, Nature.
[58] Xiang-Dong Fu,et al. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. , 2005, Molecular cell.
[59] Xin Wang,et al. Identification of Nuclear and Cytoplasmic mRNA Targets for the Shuttling Protein SF2/ASF , 2008, PloS one.
[60] T. Misteli,et al. High mobility of proteins in the mammalian cell nucleus , 2000, Nature.
[61] L. Wieslander,et al. Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription , 1994, Cell.
[62] C. Murphy,et al. A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle , 1990, The Journal of cell biology.
[63] M. Moore,et al. Spliceosome assembly and composition. , 2007, Advances in experimental medicine and biology.
[64] Xiang-Dong Fu,et al. ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle , 2005, Cell.
[65] C. R. Valentine,et al. The association of nonsense codons with exon skipping. , 1998, Mutation research.
[66] B. Frey,et al. Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. , 2004, Molecular cell.
[67] P. Bingham,et al. Developmental expression of a regulatory gene is programmed at the level of splicing. , 1987, The EMBO journal.
[68] T. Maniatis,et al. An extensive network of coupling among gene expression machines , 2002, Nature.
[69] Steven P. Gygi,et al. mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events , 2005, Cell.
[70] Michael R. Green,et al. RS domain–splicing signal interactions in splicing of U12-type and U2-type introns , 2007, Nature Structural &Molecular Biology.
[71] M. Garcia-Blanco,et al. Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. , 1997, RNA.
[72] L. Cantley,et al. SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells , 1998, The Journal of cell biology.
[73] M. Garcia-Blanco,et al. SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. , 1995, RNA.
[74] Eric Hahnen,et al. Spinal muscular atrophy: from gene to therapy. , 2006, Seminars in pediatric neurology.
[75] C. Lorson,et al. Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[76] Tom Maniatis,et al. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing , 1993, Cell.
[77] A. Krainer,et al. Correction of disease-associated exon skipping by synthetic exon-specific activators , 2003, Nature Structural Biology.
[78] S. Brenner,et al. Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. , 2005, Genes & development.
[79] R. Kole,et al. Strong RNA Splicing Enhancers Identified by a Modified Method of Cycled Selection Interact with SR Protein* , 2001, The Journal of Biological Chemistry.
[80] Phillip A Sharp,et al. Predictive Identification of Exonic Splicing Enhancers in Human Genes , 2002, Science.
[81] Leandro Quadrana,et al. Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT , 2005, Nature Structural &Molecular Biology.
[82] A. Yuryev,et al. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[83] T Pawson,et al. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. , 1996, The EMBO journal.
[84] Brenton R Graveley,et al. RS domains contact the pre-mRNA throughout spliceosome assembly. , 2005, Trends in biochemical sciences.
[85] A. Kornblihtt,et al. Mammary Epithelial-Mesenchymal Interaction Regulates Fibronectin Alternative Splicing via Phosphatidylinositol 3-Kinase* , 2004, Journal of Biological Chemistry.
[86] Martin J. Simard,et al. SRp30c Is a Repressor of 3′ Splice Site Utilization , 2002, Molecular and Cellular Biology.
[87] A. Krainer,et al. Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity , 1997, The Journal of cell biology.
[88] A. Krainer,et al. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. , 1990, Genes & development.
[89] L. Maquat,et al. Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. , 2008, Molecular cell.
[90] B. Dauwalder,et al. A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[91] M B Roth,et al. SR proteins: a conserved family of pre-mRNA splicing factors. , 1992, Genes & development.
[92] M. Moore,et al. The ever-increasing complexities of the exon junction complex. , 2004, Current opinion in cell biology.
[93] Tyson A. Clark,et al. Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. , 2007, Genes & development.
[94] J. Manley,et al. A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. , 2007, Molecular cell.
[95] J. Marie,et al. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer‐dependent splicing of the β‐tropomyosin alternative exon 6A , 1997, The EMBO journal.
[96] L. Shkreta,et al. hnRNP proteins and splicing control. , 2007, Advances in experimental medicine and biology.
[97] Adrian R. Krainer,et al. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites , 1990, Cell.
[98] G. Akusjärvi,et al. Human Splicing Factor ASF/SF2 Encodes for a Repressor Domain Required for Its Inhibitory Activity on Pre-mRNA Splicing* , 2002, The Journal of Biological Chemistry.
[99] Michael R. Green,et al. Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly. , 2004, Molecular cell.
[100] M. Abitbol,et al. Splicing Error in E1α Pyruvate Dehydrogenase mRNA Caused by Novel Intronic Mutation Responsible for Lactic Acidosis and Mental Retardation* , 2003, The Journal of Biological Chemistry.
[101] J. Manley,et al. Primary structure of the human splicing factor asf reveals similarities with drosophila regulators , 1991, Cell.
[102] Xiang-Dong Fu,et al. The superfamily of arginine/serine-rich splicing factors. , 1995, RNA.
[103] R. Reed,et al. Human homologs of yeast Prp16 and Prp17 reveal conservation of the mechanism for catalytic step II of pre‐mRNA splicing , 1998, The EMBO journal.
[104] E. Buratti,et al. Splicing Factors Induce Cystic Fibrosis Transmembrane Regulator Exon 9 Skipping through a Nonevolutionary Conserved Intronic Element* , 2000, The Journal of Biological Chemistry.
[105] H. Schaal,et al. Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer , 2008, Nucleic acids research.
[106] B R Franza,et al. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. , 1998, RNA.
[107] J. Lis,et al. Specific SR protein-dependent splicing substrates identified through genomic SELEX. , 2003, Nucleic acids research.
[108] E. Makarov,et al. The 65 and 110 kDa SR‐related proteins of the U4/U6·U5 tri‐snRNP are essential for the assembly of mature spliceosomes , 2001, The EMBO journal.
[109] J. G. Patton,et al. Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. , 2002, RNA.
[110] A. Krainer,et al. Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1 , 2002, Nature Genetics.
[111] J. Stévenin,et al. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers. , 1999, RNA.
[112] C. Will,et al. Splicing of a rare class of introns by the U12-dependent spliceosome , 2005, Biological chemistry.
[113] Michael Q. Zhang,et al. Exonic Splicing Enhancer Motif Recognized by Human SC35 under Splicing Conditions , 2000, Molecular and Cellular Biology.
[114] Brenda F Baker,et al. Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon , 2007, PLoS biology.
[115] A. Kornblihtt,et al. RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20 , 2006, Nature Structural &Molecular Biology.
[116] B. Rothen‐Rutishauser,et al. Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[117] Jamal Tazi,et al. Eye Development under the control of SRp55/B52-Mediated Alternative Splicing of eyeless , 2007, PloS one.
[118] K. J. Hertel,et al. Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns , 2006, PLoS biology.
[119] J. Cheng,et al. Molecular and Genetic Studies Imply Akt-mediated Signaling Promotes Protein Kinase CβII Alternative Splicing via Phosphorylation of Serine/Arginine-rich Splicing Factor SRp40* , 2005, Journal of Biological Chemistry.
[120] M. Gabut,et al. Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[121] J. Lis,et al. Pre-mRNA Splicing by the EssentialDrosophila Protein B52: Tissue and Target Specificity , 2000, Molecular and Cellular Biology.
[122] Y. Hua,et al. Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. , 2008, American journal of human genetics.
[123] Melissa S Jurica,et al. Pre-mRNA splicing: awash in a sea of proteins. , 2003, Molecular cell.
[124] S. Rowan,et al. The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[125] T. Maniatis,et al. Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus , 1990, Nature.
[126] Thaned Kangsamaksin,et al. Exon Inclusion Is Dependent on Predictable Exonic Splicing Enhancers , 2005, Molecular and Cellular Biology.
[127] J. Steitz,et al. SR splicing factors serve as adapter proteins for TAP-dependent mRNA export. , 2003, Molecular cell.
[128] A. Kornblihtt,et al. A splicing regulator promotes transcriptional elongation , 2008, Nature Structural &Molecular Biology.
[129] Jennifer L. Bachorik,et al. Transportin-SR, a Nuclear Import Receptor for SR Proteins , 1999, The Journal of cell biology.
[130] D. Cooper,et al. The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences , 1992, Human Genetics.
[131] Yoshifumi Watanabe,et al. Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. , 2008, Journal of affective disorders.
[132] M. Lai,et al. A Human Importin-β Family Protein, Transportin-SR2, Interacts with the Phosphorylated RS Domain of SR Proteins* , 2000, The Journal of Biological Chemistry.
[133] A. Krainer,et al. Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators , 1991, Cell.
[134] P. Dorrestein,et al. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. , 2008, Molecular cell.
[135] B. Blencowe,et al. Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans , 2001, Current Biology.
[136] S. Berget,et al. Exon definition may facilitate splice site selection in RNAs with multiple exons. , 1990, Molecular and cellular biology.
[137] A. Krämer,et al. The structure and function of proteins involved in mammalian pre-mRNA splicing. , 1996, Annual review of biochemistry.
[138] J. Steitz,et al. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. , 2001, Molecular cell.
[139] Fergus J. Couch,et al. The 17q23 Amplicon and Breast Cancer , 2003, Breast Cancer Research and Treatment.
[140] William Arbuthnot Sir Lane,et al. A serine kinase regulates intracellular localization of splicing factors in the cell cycle , 1994, Nature.
[141] J. Valcárcel,et al. Alternative pre-mRNA splicing: the logic of combinatorial control. , 2000, Trends in biochemical sciences.
[142] Stephen M. Mount,et al. Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor , 1995, Molecular and cellular biology.
[143] C. Stoltzfus,et al. Negative and Positive mRNA Splicing Elements Act Competitively To Regulate Human Immunodeficiency Virus Type 1 Vif Gene Expression , 2008, Journal of Virology.
[144] J. Manley,et al. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. , 1996, Genes & development.
[145] J. Manley,et al. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[146] J. Manley,et al. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. , 1997, Genes & development.
[147] A. Kornblihtt,et al. A slow RNA polymerase II affects alternative splicing in vivo. , 2003, Molecular cell.
[148] Oliver Mühlemann,et al. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA , 1996, Nature.
[149] Peter J. Shepard,et al. Conserved RNA secondary structures promote alternative splicing. , 2008, RNA.
[150] Tom Misteli,et al. The dynamics of a pre-mRNA splicing factor in living cells , 1997, Nature.
[151] P. Sharp,et al. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA* , 1977, Proceedings of the National Academy of Sciences.
[152] C. Ghigna,et al. Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas. , 1998, Cancer research.
[153] A. Zahler,et al. Distinct functions of SR proteins in alternative pre-mRNA splicing. , 1993, Science.
[154] F. Kittrell,et al. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis , 1999, Oncogene.
[155] P. Sharp,et al. The SRm160/300 splicing coactivator is required for exon-enhancer function. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[156] Y. Osheim,et al. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. , 1988, Genes & development.
[157] L. Gold,et al. Libraries for genomic SELEX. , 1997, Nucleic acids research.
[158] Xiang-Dong Fu,et al. The splicing factor SC35 has an active role in transcriptional elongation , 2008, Nature Structural &Molecular Biology.
[159] David L. Spector,et al. Nuclear speckles: a model for nuclear organelles , 2003, Nature Reviews Molecular Cell Biology.
[160] A. Krämer,et al. A Role for SRp54 during Intron Bridging of Small Introns with Pyrimidine Tracts Upstream of the Branch Point , 1998, Molecular and Cellular Biology.
[161] H. Jumaa,et al. The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation , 1997, The EMBO journal.
[162] G. Screaton,et al. Serine-Arginine (SR) Protein-like Factors That Antagonize Authentic SR Proteins and Regulate Alternative Splicing* , 2001, The Journal of Biological Chemistry.
[163] Michael R Green,et al. A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly. , 2004, Molecular cell.
[164] M. Mann,et al. Large-scale Proteomic Analysis of the Human Spliceosome References , 2006 .
[165] J. Lis,et al. The SR protein B52/SRp55 is essential for Drosophila development , 1994, Molecular and cellular biology.
[166] Tom Maniatis,et al. Selection and Characterization of Pre-mRNA Splicing Enhancers: Identification of Novel SR Protein-Specific Enhancer Sequences , 1999, Molecular and Cellular Biology.
[167] J. Steitz,et al. Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses. , 2004, RNA.
[168] A. Krainer,et al. Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. , 2001, Molecular cell.
[169] L. Lian,et al. Structural and functional analysis of RNA and TAP binding to SF2/ASF , 2007, EMBO reports.
[170] J. Howard,et al. HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages , 2008, Retrovirology.
[171] A. Krainer,et al. Identification and characterization of three members of the human SR family of pre‐mRNA splicing factors. , 1995, The EMBO journal.
[172] Yiannis A. Savva,et al. A Regulator of Dscam Mutually Exclusive Splicing , 2007 .
[173] M. Carmo-Fonseca,et al. Splicing Factors SF1 and U2AF Associate in Extraspliceosomal Complexes , 2008, Molecular and Cellular Biology.
[174] A. Krainer,et al. Listening to silence and understanding nonsense: exonic mutations that affect splicing , 2002, Nature Reviews Genetics.
[175] K. Lynch. Regulation of alternative splicing by signal transduction pathways. , 2007, Advances in experimental medicine and biology.
[176] M. Garcia-Blanco,et al. Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors , 1994, Nature.
[177] M. Gabut,et al. SR proteins as potential targets for therapy. , 2006, Progress in molecular and subcellular biology.
[178] F. Muntoni,et al. Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[179] C. Will,et al. Spliceosomal UsnRNP biogenesis, structure and function. , 2001, Current opinion in cell biology.
[180] J. G. Patton,et al. Growth Hormone Deficiency and Splicing Fidelity , 2008, Journal of Biological Chemistry.
[181] J. Manley,et al. Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability , 2005, Cell.
[182] P. Argos,et al. Cloning of the human cDNA for the U1 RNA‐associated 70K protein. , 1986, The EMBO journal.
[183] James Stévenin,et al. Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA. , 2004, Progress in nucleic acid research and molecular biology.
[184] A. Krainer,et al. Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF. , 1993, The EMBO journal.
[185] Brenton R Graveley,et al. Mutually Exclusive Splicing of the Insect Dscam Pre-mRNA Directed by Competing Intronic RNA Secondary Structures , 2005, Cell.
[186] J. Steitz,et al. SRprises along a messenger's journey. , 2005, Molecular cell.
[187] Xiang-Dong Fu,et al. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. , 2005, Molecular biology of the cell.
[188] J. Cáceres,et al. Functional characterization of SR and SR‐related genes in Caenorhabditis elegans , 2000, The EMBO journal.
[189] L. Gold,et al. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. , 1990, Science.
[190] M. Frolov,et al. Specific Role of the SR Protein Splicing Factor B52 in Cell Cycle Control in Drosophila , 2006, Molecular and Cellular Biology.
[191] C. Shin,et al. Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock , 2004, Nature.
[192] Tyson A. Clark,et al. Nova regulates brain-specific splicing to shape the synapse , 2005, Nature Genetics.
[193] J. Manley,et al. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. , 1995, The EMBO journal.
[194] M. Tohyama,et al. Human Tra2 Proteins Are Sequence-Specific Activators of Pre-mRNA Splicing , 1998, Cell.
[195] J. Sanford,et al. Developmental regulation of SR protein phosphorylation and activity. , 1999, Genes & development.
[196] A. Krainer,et al. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[197] Douglas L. Black,et al. Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1 , 2003, Molecular and Cellular Biology.
[198] Andrea Scozzafava,et al. Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome. , 2005, Current pharmaceutical design.
[199] Y. Shimura,et al. A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. , 1996, Genes & development.
[200] D. Rekosh,et al. The Shuttling SR Protein 9G8 Plays a Role in Translation of Unspliced mRNA Containing a Constitutive Transport Element* , 2007, Journal of Biological Chemistry.
[201] J. Cáceres,et al. The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1. , 2008, Molecular cell.
[202] A. Krainer,et al. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. , 2007, Molecular cell.
[203] T. Cooper,et al. Identification of a new class of exonic splicing enhancers by in vivo selection , 1997, Molecular and cellular biology.
[204] Jane Y. Wu,et al. Functional properties of p54, a novel SR protein active in constitutive and alternative splicing , 1996, Molecular and cellular biology.
[205] Xiangdong Xu,et al. SC35 plays a role in T cell development and alternative splicing of CD45. , 2001, Molecular cell.
[206] S. Brenner,et al. Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements , 2007, Nature.
[207] E. Buratti,et al. Exon Enhancer Elements in the Fibronectin EDA Proteins by Mouse and Human Polypurinic RNA Folding Affects the Recruitment of SR , 2004 .
[208] H. Lou,et al. Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20 , 1998, Molecular and Cellular Biology.
[209] R. Roberts,et al. An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA , 1977, Cell.
[210] B. Blencowe,et al. An RNA map predicting Nova-dependent splicing regulation , 2006, Nature.
[211] Anton J. Enright,et al. A genome-wide survey of RS domain proteins. , 2001, RNA.
[212] D. Cazalla,et al. Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[213] A. Krainer,et al. Identification of Functional Exonic Splicing Enhancer Motifs Recognized by Individual Sr Proteins Using an in Vitro Randomization and Functional Selection Procedure, We Have Identified Three Novel Classes of Exonic Splicing Enhancers (eses) Recognized by Human Sf2/asf, Srp40, and Srp55, Respectively , 2022 .
[214] C. Lorenz,et al. Genomic systematic evolution of ligands by exponential enrichment (Genomic SELEX) for the identification of protein-binding RNAs independent of their expression levels , 2006, Nature Protocols.
[215] J. Manley,et al. Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. , 1995, RNA.
[216] T. Möröy,et al. The impact of alternative splicing in vivo: mouse models show the way. , 2007, RNA.
[217] B. Graveley. Sorting out the complexity of SR protein functions. , 2000, RNA.