Role of VEGF and VEGFR2 Receptor in Reversal of ALS-CSF Induced Degeneration of NSC-34 Motor Neuron Cell Line

[1]  G. Olmos,et al.  Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons , 2013, Front. Cell. Neurosci..

[2]  P. Carmeliet,et al.  VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration , 2013, Cellular and Molecular Life Sciences.

[3]  R. Tapia,et al.  Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo , 2012, ASN neuro.

[4]  C. Ruhrberg,et al.  VEGF Signaling through Neuropilin 1 Guides Commissural Axon Crossing at the Optic Chiasm , 2011, Neuron.

[5]  T. Raju,et al.  Vascular Endothelial Growth Factor Attenuates Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line Induced by Cerebrospinal Fluid of Sporadic Amyotrophic Lateral Sclerosis Patients , 2011, Neurodegenerative Diseases.

[6]  Tamar Licht,et al.  Reversible modulations of neuronal plasticity by VEGF , 2011, Proceedings of the National Academy of Sciences.

[7]  T. Raju,et al.  Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients , 2011, Neurobiology of Disease.

[8]  T. Raju,et al.  Down regulation of trophic factors in neonatal rat spinal cord after administration of cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients , 2011, Journal of Neural Transmission.

[9]  W. Robberecht,et al.  VEGF protects motor neurons against excitotoxicity by upregulation of GluR2 , 2010, Neurobiology of Aging.

[10]  R. Tapia,et al.  VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3‐K pathway and inhibition of p38MAPK , 2010, Journal of neurochemistry.

[11]  Paul Antoine Salin,et al.  Matrix-Binding Vascular Endothelial Growth Factor (VEGF) Isoforms Guide Granule Cell Migration in the Cerebellum via VEGF Receptor Flk1 , 2010, The Journal of Neuroscience.

[12]  Christiana Ruhrberg,et al.  VEGF in the nervous system , 2010, Organogenesis.

[13]  T. Raju,et al.  Exposure to CSF from sporadic amyotrophic lateral sclerosis patients induces morphological transformation of astroglia and enhances GFAP and S100β expression , 2010, Neuroscience Letters.

[14]  I. Goshen,et al.  VEGF is required for dendritogenesis of newly born olfactory bulb interneurons , 2010, Development.

[15]  E. Feldman,et al.  Vascular endothelial growth factor prevents G93A‐SOD1‐induced motor neuron degeneration , 2009, Developmental neurobiology.

[16]  P. Carmeliet,et al.  Role and therapeutic potential of VEGF in the nervous system. , 2009, Physiological reviews.

[17]  T. Raju,et al.  Cerebrospinal Fluid from sporadic Amyotrophic Lateral Sclerosis patients induces degeneration of a cultured motor neuron cell line , 2009, Brain Research.

[18]  A. Mahadevan,et al.  Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: Relevance to lower incidence of Parkinson's disease , 2009, Neuroscience.

[19]  T. Raju,et al.  Exposure to cerebrospinal fluid of sporadic Amyotrophic Lateral Sclerosis patients alters Nav1.6 and Kv1.6 channel expression in rat spinal motor neurons , 2009, Brain Research.

[20]  G. Olmos,et al.  Vascular endothelial growth factor protects motoneurons from serum deprivation–induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition , 2009, Neuroscience.

[21]  H. Mitsumoto,et al.  Outcomes research in amyotrophic lateral sclerosis: Lessons learned from the amyotrophic lateral sclerosis clinical assessment, research, and education database , 2009, Annals of neurology.

[22]  J. Rosenstein,et al.  Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury , 2008, Experimental Neurology.

[23]  G. Olmos,et al.  Vascular endothelial growth factor protects spinal cord motoneurons against glutamate‐induced excitotoxicity via phosphatidylinositol 3‐kinase , 2008, Journal of neurochemistry.

[24]  Honglin Li,et al.  Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: impact of duration of untreated disease. , 2007, Clinical immunology.

[25]  A. Zepeda,et al.  Vascular Endothelial Growth Factor Prevents Paralysis and Motoneuron Death in a Rat Model of Excitotoxic Spinal Cord Neurodegeneration , 2007, Journal of neuropathology and experimental neurology.

[26]  G. Savettieri,et al.  Neurons produce FGF2 and VEGF and secrete them at least in part by shedding extracellular vesicles , 2007, Journal of cellular and molecular medicine.

[27]  S. W. Kim,et al.  Hypoxia-inducible expression of vascular endothelial growth factor for the treatment of spinal cord injury in a rat model. , 2007, Journal of neurosurgery. Spine.

[28]  T. Raju,et al.  Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients , 2007, Journal of the Neurological Sciences.

[29]  T. Raju,et al.  Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord , 2007, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[30]  M. Fernando,et al.  Expression of Vascular Endothelial Growth Factor and Its Receptors in the Central Nervous System in Amyotrophic Lateral Sclerosis , 2006, Journal of neuropathology and experimental neurology.

[31]  P. Shaw,et al.  Characterization of the caspase cascade in a cell culture model of SOD1‐related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition , 2005, Neuropathology and applied neurobiology.

[32]  Christoph Schmitz,et al.  Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS , 2005, Nature Neuroscience.

[33]  P. Carmeliet,et al.  VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS? , 2004, Trends in molecular medicine.

[34]  P. Carmeliet,et al.  VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model , 2004, Nature.

[35]  J. Rosenstein,et al.  Neurotrophic Effects of Vascular Endothelial Growth Factor on Organotypic Cortical Explants and Primary Cortical Neurons , 2003, The Journal of Neuroscience.

[36]  Peter Carmeliet,et al.  Blood vessels and nerves: common signals, pathways and diseases , 2003, Nature Reviews Genetics.

[37]  Zhu Yonghua,et al.  Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[38]  P. Alladi,et al.  Effect of prenatal auditory enrichment on developmental expression of synaptophysin and syntaxin 1 in chick brainstem auditory nuclei , 2002, Neuroscience.

[39]  K. Jin,et al.  Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[40]  W. Stewart,et al.  Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System* , 2002, The Journal of Biological Chemistry.

[41]  Till Acker,et al.  Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration , 2001, Nature Genetics.

[42]  M. Vitek,et al.  Vascular endothelial growth factor rescues hippocampal neurons from glutamate‐induced toxicity: signal transduction cascades , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  T. Raju,et al.  Cyclophosphamide attenuates the degenerative changes induced by CSF from patients with amyotrophic lateral sclerosis in the neonatal rat spinal cord , 2001, Journal of the Neurological Sciences.

[44]  M. Kanje,et al.  Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor , 2000, The European journal of neuroscience.

[45]  F. Menzies,et al.  Development and Characterisation of a Glutamate‐Sensitive Motor Neurone Cell Line , 2000, Journal of neurochemistry.

[46]  P. Stieg,et al.  Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. , 2000, Science.

[47]  Napoleone Ferrara,et al.  VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation , 1999, Nature Medicine.

[48]  L J Martin,et al.  Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism. , 1999, Journal of neuropathology and experimental neurology.

[49]  M. Schwab,et al.  VEGF mRNA Induction Correlates With Changes in the Vascular Architecture Upon Spinal Cord Damage in the Rat , 1997, The European journal of neuroscience.

[50]  A. Nalini,et al.  Temporary amelioration of symptoms with intravenous cyclophosphamide in amyotrophic lateral sclerosis , 1997, Journal of the Neurological Sciences.

[51]  C. Portera-Cailliau,et al.  Excitotoxic neuronal death in the immature brain is an apoptosis‐necrosis morphological continuum , 1997, The Journal of comparative neurology.

[52]  L. Colom,et al.  Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[53]  P. Tofilon,et al.  Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures , 1995, Glia.