Activation of retinoid X receptors induces apoptosis in HL-60 cell lines

Retinoids induce myeloblastic leukemia (HL-60) cells to differentiate into granulocytes, which subsequently die by apoptosis. Retinoid action is mediated through at least two classes of nuclear receptors: retinoic acid receptors, which bind both all-trans retinoic acid and 9-cis retinoic acid, and retinoid X receptors, which bind only 9-cis retinoic acid. Using receptor-selective synthetic retinoids and HL-60 cell sublines with different retinoid responsiveness, we have investigated the contribution that each class of receptors makes to the processes of cellular differentiation and death. Our results demonstrate that ligand activation of retinoic acid receptors is sufficient to induce differentiation, whereas ligand activation of retinoid X receptors is essential for the induction of apoptosis in HL-60 cell lines.

[1]  R. Chandraratna,et al.  Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs , 1994 .

[2]  M. Cleary,et al.  Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. , 1994, Blood.

[3]  D. Mangelsdorf,et al.  Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. , 1994, Journal of medicinal chemistry.

[4]  S. Pemrick,et al.  The retinoid receptors. , 1994, Leukemia.

[5]  S. Collins,et al.  Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes. , 1994, Blood.

[6]  J. Pike,et al.  Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism. , 1993, The Journal of biological chemistry.

[7]  J. Lehmann,et al.  Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity. , 1993, Journal of medicinal chemistry.

[8]  G. van Zant,et al.  Apoptosis and hematopoiesis in murine fetal liver. , 1993, Blood.

[9]  J. Lehmann,et al.  Retinoids selective for retinoid X receptor response pathways. , 1992, Science.

[10]  G. Folkers,et al.  A cyclic AMP response element is involved in retinoic acid-dependent RAR beta 2 promoter activation. , 1992, Nucleic acids research.

[11]  C. Haslett.  Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. , 1992, Clinical science.

[12]  R. Stockley,et al.  The induction by human interleukin-6 of apoptosis in the promonocytic cell line U937 and human neutrophils. , 1992, The Journal of biological chemistry.

[13]  K. Robertson,et al.  Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. , 1992, Blood.

[14]  K. Robertson,et al.  Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells , 1992, Molecular and cellular biology.

[15]  J. Lehmann,et al.  Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid , 1992, Nature.

[16]  P. Lemotte,et al.  A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Z. Parandoosh,et al.  Interaction of glucocorticoid analogues with the human glucocorticoid receptor , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[18]  D. Green,et al.  Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. , 1992, Cancer research.

[19]  Gregor Eichele,et al.  9-cis retinoic acid is a high affinity ligand for the retinoid X receptor , 1992, Cell.

[20]  J. Grippo,et al.  9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα , 1992, Nature.

[21]  M. Pierotti,et al.  bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. , 1992, Blood.

[22]  G. Morriss-Kay.  Retinoids in normal development and teratogenesis , 1992 .

[23]  L. Fésüs,et al.  Apoptosis: molecular mechanisms in programmed cell death. , 1991, European journal of cell biology.

[24]  T. Suda,et al.  Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. , 1991, Blood.

[25]  B. Shroot,et al.  Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. , 1991, Molecular pharmacology.

[26]  K. Umesono,et al.  A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR , 1991, Cell.

[27]  D. van der Helm,et al.  Novel heteroarotinoids: synthesis and biological activity. , 1991, Journal of medicinal chemistry.

[28]  M. Lanotte,et al.  Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line , 1991, Journal of cellular physiology.

[29]  A. Wyllie,et al.  Apoptosis: mechanisms and roles in pathology. , 1991, International review of experimental pathology.

[30]  J. Spivak,et al.  Erythropoietin is both a mitogen and a survival factor. , 1991, Blood.

[31]  T. Cotter,et al.  Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL‐60 cells , 1990, Cell and tissue kinetics.

[32]  R. Evans,et al.  Nuclear receptor that identifies a novel retinoic acid response pathway , 1990, Nature.

[33]  S. Collins,et al.  Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha) , 1990, Molecular and cellular biology.

[34]  M. Koury,et al.  Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. , 1990, Science.

[35]  T G Cotter,et al.  HL‐60 cells induced to differentiate towards neutrophils subsequently die via apoptosis , 1990, Clinical and experimental immunology.

[36]  Y. Hashimoto,et al.  Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR's). , 1990, Biochemical and biophysical research communications.

[37]  N. Hogg,et al.  Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis , 1990, Nature.

[38]  K. Sulik,et al.  Retinoic-acid-induced limb-reduction defects: perturbation of zones of programmed cell death as a pathogenetic mechanism. , 1989, Teratology.

[39]  Y. Hashimoto,et al.  Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids. , 1989, Journal of medicinal chemistry.

[40]  M. Walport,et al.  Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. , 1989, The Journal of clinical investigation.

[41]  A. Dejean,et al.  Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. , 1989, The EMBO journal.

[42]  K. Umesono,et al.  Retinoic acid and thyroid hormone induce gene expression through a common responsive element , 1988, Nature.

[43]  V. Giguère,et al.  Identification of a receptor for the morphogen retinoic acid , 1987, Nature.

[44]  S. Collins,et al.  The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. , 1987, Blood.

[45]  M. Summers,et al.  A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures. , 1987 .

[46]  M. Sporn,et al.  Structure-activity relationships of a new series of retinoidal benzoic acid derivatives as measured by induction of differentiation of murine F9 teratocarcinoma cells and human HL-60 promyelocytic leukemia cells. , 1983, Cancer research.

[47]  S. Collins,et al.  Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[48]  A. Norman,et al.  An hydroxylapatite batch assay for the quantitation of 1alpha,25-dihydroxyvitamin D3-receptor complexes. , 1979, Analytical biochemistry.

[49]  S. Collins,et al.  Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Collins,et al.  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture , 1977, Nature.