Molecular principles of metastasis: a hallmark of cancer revisited

[1]  D. Munn,et al.  Role of the Tumor Microenvironment , 2021, Cancer Immunotherapy Principles and Practice.

[2]  D. Vigetti,et al.  Revisiting the hallmarks of cancer: the role of hyaluronan. , 2020, Seminars in cancer biology.

[3]  Deepak Kanojia,et al.  Landscape of Combination Therapy Trials in Breast Cancer Brain Metastasis. , 2020, International journal of cancer.

[4]  Yujie Huang,et al.  Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models , 2020, Nature Communications.

[5]  S. E. Harvey,et al.  The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing , 2020, Nature Communications.

[6]  N. Birkbak,et al.  Cancer Genome Evolutionary Trajectories in Metastasis. , 2020, Cancer cell.

[7]  Qiang Yu,et al.  ULK1 phosphorylates Exo70 to suppress breast cancer metastasis , 2020, Nature Communications.

[8]  Xiao Wang,et al.  Identification of FOXN4 as a tumor suppressor of breast carcinogenesis via the activation of TP53 and deactivation of Notch signaling. , 2020, Gene.

[9]  M. Salmerón-Sánchez,et al.  The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis , 2020, Nature Metabolism.

[10]  Ashley M. Laughney,et al.  L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer , 2020, Nature Cancer.

[11]  Ming Li,et al.  LOXL1-AS1 Drives The Progression Of Gastric Cancer Via Regulating miR-142-5p/PIK3CA Axis , 2019, OncoTargets and therapy.

[12]  I. Gögenur,et al.  Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery , 2019, International journal of cancer.

[13]  Atique U. Ahmed,et al.  Diagnostic Clinical Trials in Breast Cancer Brain Metastases: Barriers and Innovations. , 2019, Clinical breast cancer.

[14]  I. Ulasov,et al.  Editing Cytoprotective Autophagy in Glioma: An Unfulfilled Potential for Therapy. , 2019, Trends in molecular medicine.

[15]  D. Schadendorf,et al.  Metabolic heterogeneity confers differences in melanoma metastatic potential , 2019, Nature.

[16]  Junfeng Wang,et al.  VN-NDP: A Neighbor Discovery Protocol Based on Virtual Nodes in Mobile WSNs , 2019, Sensors.

[17]  Joel S. Bader,et al.  E-cadherin is required for metastasis in multiple models of breast cancer , 2019, Nature.

[18]  R. Iozzo,et al.  Dissecting the role of hyaluronan synthases in the tumor microenvironment , 2019, The FEBS journal.

[19]  Inti Zlobec,et al.  Synaptic proximity enables NMDAR signaling to promote brain metastasis , 2019, Nature.

[20]  L. Wessels,et al.  Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis , 2019, Nature.

[21]  Mazen A. Juratli,et al.  In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma , 2019, Science Translational Medicine.

[22]  G. Lu,et al.  MicroRNA-340-5p suppresses non-small cell lung cancer cell growth and metastasis by targeting ZNF503 , 2019, Cellular & Molecular Biology Letters.

[23]  A. Kikuchi.  Faculty Opinions recommendation of Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[24]  Y. Allory,et al.  Progenitors from the central nervous system drive neurogenesis in cancer , 2019, Nature.

[25]  H. Kuipers,et al.  Hyaluronan in immune dysregulation and autoimmune diseases. , 2019, Matrix biology : journal of the International Society for Matrix Biology.

[26]  Y. Bao,et al.  Partial nephrectomy vs cryoablation for T1a renal cell carcinoma: A comparison of survival benefit stratified by tumour size. , 2019, Cancer epidemiology.

[27]  H. Kohler,et al.  Glucocorticoids promote breast cancer metastasis , 2019, Nature.

[28]  M. Fares,et al.  Natural killer cells in the brain tumor microenvironment: Defining a new era in neuro-oncology , 2019, Surgical neurology international.

[29]  Yibin Kang,et al.  Bone Vascular Niche E-selectin Induces Mesenchymal-Epithelial Transition and Wnt Activation in Cancer Cells to Promote Bone Metastasis , 2019, Nature Cell Biology.

[30]  Jianming Xu,et al.  Surufatinib in Advanced Well-Differentiated Neuroendocrine Tumors: A Multicenter, Single-Arm, Open-Label, Phase Ib/II Trial , 2019, Clinical Cancer Research.

[31]  Xianwei Yang,et al.  Transhepatic-intrahepatic branches of the portal vein catheterization for ex vivo liver resection and autotransplantation , 2019, Medicine.

[32]  B. Helmink,et al.  The microbiome, cancer, and cancer therapy , 2019, Nature Medicine.

[33]  A. Maitra.  Molecular envoys pave the way for pancreatic cancer to invade the liver , 2019, Nature.

[34]  C. Verfaillie,et al.  Breast cancer cells rely on environmental pyruvate to shape the metastatic niche , 2019, Nature.

[35]  M. Borad,et al.  Hepatocytes direct the formation of a pro-metastatic niche in the liver. , 2019, Nature.

[36]  Atique U. Ahmed,et al.  Current state of clinical trials in breast cancer brain metastases. , 2019, Neuro-oncology practice.

[37]  G. Koh,et al.  Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation , 2019, Science.

[38]  N. Beerenwinkel,et al.  Neutrophils escort circulating tumour cells to enable cell cycle progression , 2019, Nature.

[39]  M. Fares,et al.  Immune checkpoint inhibitors: Advances and impact in neuro-oncology , 2019, Surgical neurology international.

[40]  G. Christofori,et al.  Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis. , 2019, Cancer cell.

[41]  M. Inoue,et al.  Dormancy in cancer , 2019, Cancer science.

[42]  K. Khosrotehrani,et al.  Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis , 2019, Nature Communications.

[43]  B. Goh,et al.  Role of tumor-derived exosomes in cancer metastasis. , 2019, Biochimica et biophysica acta. Reviews on cancer.

[44]  F. Castro-Giner,et al.  Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding , 2019, Cell.

[45]  I. Keklikoglou,et al.  Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models , 2018, Nature Cell Biology.

[46]  Jawad Fares,et al.  Neurogenesis in the adult hippocampus: history, regulation, and prospective roles , 2018, The International journal of neuroscience.

[47]  Qin Li,et al.  MiR-137 suppresses migration and invasion by targeting EZH2-STAT3 signaling in human hepatocellular carcinoma. , 2018, Pathology, research and practice.

[48]  P. Sassone-Corsi,et al.  The emerging link between cancer, metabolism, and circadian rhythms , 2018, Nature Medicine.

[49]  Yun Xu,et al.  miR-10b Downregulated by DNA Methylation Acts as a Tumor Suppressor in HPV-Positive Cervical Cancer via Targeting Tiam1 , 2018, Cellular Physiology and Biochemistry.

[50]  J. Goetz.  Metastases go with the flow , 2018, Science.

[51]  Li-Yu Daisy Liu,et al.  Determination of the Pseudoscalar Decay Constant f_{D_{s}^{+}} via D_{s}^{+}→μ^{+}ν_{μ}. , 2018, Physical review letters.

[52]  Stephen T. C. Wong,et al.  The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. , 2018, Cancer cell.

[53]  Wei Zhang,et al.  MicroRNA-135a-3p is downregulated and serves as a tumour suppressor in ovarian cancer by targeting CCR2. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[54]  Z. Werb,et al.  Tumour heterogeneity and metastasis at single-cell resolution , 2018, Nature Cell Biology.

[55]  Stephen M. Douglass,et al.  Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. , 2018, Cancer discovery.

[56]  Stephen M. Douglass,et al.  Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. , 2018, Cancer discovery.

[57]  R. Iozzo,et al.  Extracellular matrix: The driving force of mammalian diseases. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[58]  Michael S. Goldberg,et al.  Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice , 2018, Science.

[59]  Hua Xu,et al.  MicroRNA-3619-5p suppresses bladder carcinoma progression by directly targeting β-catenin and CDK2 and activating p21 , 2018, Cell Death & Disease.

[60]  A. Kundaje,et al.  Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin. , 2018, Cancer discovery.

[61]  S. Ricard-Blum,et al.  Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics. , 2018, Chemical reviews.

[62]  Hongye Zhu,et al.  Downregulation of MiR-1297 predicts poor prognosis and enhances gastric cancer cell growth by targeting CREB1. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[63]  M. Atkins,et al.  Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain , 2018, The New England journal of medicine.

[64]  J. Tie,et al.  MiR-340-5p is a potential prognostic indicator of colorectal cancer and modulates ANXA3. , 2018, European review for medical and pharmacological sciences.

[65]  K. Pantel,et al.  miRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis-Associated Genes. , 2018, Cancer research.

[66]  Lifeng Lao,et al.  miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma , 2018, International journal of immunopathology and pharmacology.

[67]  Hellyeh Hamidi,et al.  Every step of the way: integrins in cancer progression and metastasis , 2018, Nature Reviews Cancer.

[68]  M. Touvier,et al.  Circadian nutritional behaviours and cancer risk: New insights from the NutriNet‐santé prospective cohort study: Disclaimers , 2018, International journal of cancer.

[69]  Ting Wang,et al.  MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma. , 2018, Cancer letters.

[70]  C. Iacobuzio-Donahue,et al.  Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases , 2017, Science.

[71]  A. Moustakas,et al.  Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[72]  A. Andriulli,et al.  Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies , 2018, Microbiome.

[73]  Zhijin Zhang,et al.  Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling , 2018, Cellular Physiology and Biochemistry.

[74]  T. Voet,et al.  Identification of the tumour transition states occurring during EMT , 2018, Nature.

[75]  N. Paul,et al.  Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells , 2017, bioRxiv.

[76]  S. Pushalkar,et al.  The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. , 2018, Cancer discovery.

[77]  Goberdhan P Dimri,et al.  Timosaponin A‐III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells , 2018, Molecular carcinogenesis.

[78]  Z. Bago-Horvath,et al.  Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice , 2018, Science.

[79]  Eelco F. J. Meijer,et al.  Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice , 2018, Science.

[80]  Xiaoping Zhou,et al.  The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts , 2018, Genome Biology.

[81]  Li-Yu Daisy Liu,et al.  Observation of the Semileptonic Decay D^{0}→a_{0}(980)^{-}e^{+}ν_{e} and Evidence for D^{+}→a_{0}(980)^{0}e^{+}ν_{e}. , 2018, Physical review letters.

[82]  J. Aguirre-Ghiso,et al.  Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis , 2018 .

[83]  Kai Chen,et al.  Targeting of NT5E by miR-30b and miR-340 attenuates proliferation, invasion and migration of gallbladder carcinoma. , 2018, Biochimie.

[84]  G. Bhanot,et al.  Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. , 2018, Journal of the National Cancer Institute.

[85]  Charles M. Perou,et al.  Asparagine bioavailability governs metastasis in a model of breast cancer , 2018, Nature.

[86]  Chen Huang,et al.  HOXD3 targeted by miR-203a suppresses cell metastasis and angiogenesis through VEGFR in human hepatocellular carcinoma cells , 2018, Scientific Reports.

[87]  P. Steeg,et al.  Metastasis suppressors: functional pathways , 2018, Laboratory Investigation.

[88]  Wei Jia,et al.  LINC00473 antagonizes the tumour suppressor miR‐195 to mediate the pathogenesis of Wilms tumour via IKKα , 2018, Cell proliferation.

[89]  Junhui Wan,et al.  MicroRNA-381 inhibits cell proliferation and invasion in endometrial carcinoma by targeting the IGF-1R. , 2017, Molecular medicine reports.

[90]  Samuel F. Bakhoum,et al.  Chromosomal instability drives metastasis through a cytosolic DNA response , 2017, Nature.

[91]  P. Hinds.  Faculty of 1000 evaluation for Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression. , 2017 .

[92]  Katarzyna Pietraszek-Gremplewicz,et al.  Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners? , 2017, Matrix biology : journal of the International Society for Matrix Biology.

[93]  O. Sansom,et al.  Neutrophils: Homing in on the myeloid mechanisms of metastasis , 2017, Molecular immunology.

[94]  J. Condeelis,et al.  A permanent window for the murine lung enables high-resolution imaging of cancer metastasis , 2017, Nature Methods.

[95]  Peter C Searson,et al.  Mitosis-Mediated Intravasation in a Tissue-Engineered Tumor-Microvessel Platform. , 2017, Cancer research.

[96]  Alissa M. Weaver,et al.  Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin , 2017, The Journal of cell biology.

[97]  G. Zambruno,et al.  Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

[98]  Alberto Martin,et al.  Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer. , 2017, Cancer research.

[99]  Zhigang Zhang,et al.  Kaposi’s Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes , 2017, mBio.

[100]  H. T. Park,et al.  Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response , 2017, Nature Communications.

[101]  Noam Shental,et al.  Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine , 2017, Science.

[102]  Stefan Offermanns,et al.  Intravascular Survival and Extravasation of Tumor Cells. , 2017, Cancer cell.

[103]  S. Smola.  Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy , 2017, Viruses.

[104]  Richard J. Jones,et al.  Chondroitin sulfate proteoglycan serglycin influences protein cargo loading and functions of tumor-derived exosomes , 2017, Oncotarget.

[105]  Laurie J. Gay,et al.  The sleeping ugly: Tumour microenvironment's act to make or break the spell of dormancy. , 2017, Biochimica et biophysica acta. Reviews on cancer.

[106]  Fangfang Guo,et al.  Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy , 2017, Cell.

[107]  Priya Bhardwaj,et al.  Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF , 2017, Nature Cell Biology.

[108]  William A. Flavahan,et al.  Epigenetic plasticity and the hallmarks of cancer , 2017, Science.

[109]  Shao-Cong Sun,et al.  NF-κB signaling in inflammation , 2017, Signal Transduction and Targeted Therapy.

[110]  Johannes G. Reiter,et al.  Origins of lymphatic and distant metastases in human colorectal cancer , 2017, Science.

[111]  Robert J. Lonigro,et al.  Integrative Clinical Genomics of Metastatic Cancer , 2017, Nature.

[112]  Jonathan J. Chen,et al.  Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration , 2017, Nature Communications.

[113]  Ashwini Naik,et al.  Phylogenetic ctDNA analysis depicts early stage lung cancer evolution , 2017, Nature.

[114]  A. Mastro,et al.  Role of Megakaryocytes in Breast Cancer Metastasis to Bone. , 2017, Cancer research.

[115]  M. Franchi,et al.  Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition , 2017, Scientific Reports.

[116]  Thomas R. Cox,et al.  Pre-metastatic niches: organ-specific homes for metastases , 2017, Nature Reviews Cancer.

[117]  J. Massagué,et al.  Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis , 2017, Cell.

[118]  Ian D. Wilson,et al.  Gut microbiota modulation of chemotherapy efficacy and toxicity , 2017, Nature Reviews Gastroenterology &Hepatology.

[119]  Jung-Joon Min,et al.  Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin , 2017, Science Translational Medicine.

[120]  M. Mori,et al.  The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. , 2017, Cancer discovery.

[121]  R. Weinberg,et al.  Emerging Biological Principles of Metastasis , 2017, Cell.

[122]  V. Orian-Rousseau,et al.  A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer , 2017, Oncotarget.

[123]  Edward Ryder,et al.  Genome-wide in vivo screen identifies novel host regulators of metastatic colonization , 2017, Nature.

[124]  R. Gomis,et al.  Tumor cell dormancy , 2017, Molecular oncology.

[125]  Camille Stephan-Otto Attolini,et al.  Targeting metastasis-initiating cells through the fatty acid receptor CD36 , 2016, Nature.

[126]  Gerhard Christofori,et al.  Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe? , 2016, Current opinion in cell biology.

[127]  Ping Zhang,et al.  Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion , 2016, Journal of experimental & clinical cancer research : CR.

[128]  Christian M. Metallo,et al.  CRY2 and FBXL3 Cooperatively Degrade c-MYC. , 2016, Molecular cell.

[129]  H. Hsu,et al.  Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner , 2016, Oncogene.

[130]  Liang Xu,et al.  Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis , 2016, Cell Death & Disease.

[131]  C. Sonnenschein,et al.  Carcinogenesis explained within the context of a theory of organisms. , 2016, Progress in biophysics and molecular biology.

[132]  Yan Du,et al.  Low-molecular-weight hyaluronan (LMW-HA) accelerates lymph node metastasis of melanoma cells by inducing disruption of lymphatic intercellular adhesion , 2016, Oncoimmunology.

[133]  K. Macleod,et al.  Autophagy in cancer metastasis , 2016, Oncogene.

[134]  M. Pasparakis,et al.  Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis , 2016, Nature.

[135]  J. Thiery,et al.  Exosome-Mediated Metastasis: From Epithelial-Mesenchymal Transition to Escape from Immunosurveillance. , 2016, Trends in pharmacological sciences.

[136]  P. Stadler,et al.  MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation , 2016, Nature Communications.

[137]  Simak Ali,et al.  Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts , 2016, Clinical Cancer Research.

[138]  I. Garkavtsev,et al.  Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer , 2016, Oncotarget.

[139]  N. Itano,et al.  Hyaluronan: A modulator of the tumor microenvironment. , 2016, Cancer letters.

[140]  D. Pardoll,et al.  The Myeloid Immune Signature of Enterotoxigenic Bacteroides Fragilis-Induced Murine Colon Tumorigenesis , 2016, Mucosal Immunology.

[141]  T. Martin,et al.  Bone metastasis: the importance of the neighbourhood , 2016, Nature Reviews Cancer.

[142]  D. Spillmann,et al.  Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma , 2016, PloS one.

[143]  J. Massagué,et al.  Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer , 2016, Nature.

[144]  Klaus Pantel,et al.  Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy. , 2016, Cancer discovery.

[145]  Jan Lammerding,et al.  Nuclear envelope rupture and repair during cancer cell migration , 2016, Science.

[146]  E. Rankin,et al.  Hypoxic control of metastasis , 2016, Science.

[147]  Andrew J. Ewald,et al.  A collective route to metastasis: Seeding by tumor cell clusters , 2016, Science.

[148]  A. Carnero,et al.  The hypoxic microenvironment: A determinant of cancer stem cell evolution , 2016, BioEssays : news and reviews in molecular, cellular and developmental biology.

[149]  P. Steeg,et al.  Targeting metastasis , 2016, Nature Reviews Cancer.

[150]  Hailong Fu,et al.  The emerging roles of exosomes in tumor–stroma interaction , 2016, Journal of Cancer Research and Clinical Oncology.

[151]  M. Headley,et al.  Visualization of immediate immune responses to pioneer metastatic cells in the lung , 2016, Nature.

[152]  M R Speicher,et al.  The biology of circulating tumor cells , 2016, Oncogene.

[153]  M. Kowalska,et al.  Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity , 2016, PloS one.

[154]  Michael R. Speicher,et al.  The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis , 2016, Science Translational Medicine.

[155]  A. Theocharis,et al.  Extracellular matrix structure. , 2016, Advanced drug delivery reviews.

[156]  J. Massagué,et al.  Metastatic colonization by circulating tumour cells , 2016, Nature.

[157]  Y. H. Soung,et al.  Emerging roles of exosomes in cancer invasion and metastasis , 2016, BMB reports.

[158]  C. Dang,et al.  MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. , 2015, Cell Metabolism.

[159]  S. Ramaswamy,et al.  Mechanisms of Cancer Cell Dormancy--Another Hallmark of Cancer? , 2015, Cancer research.

[160]  V. LeBleu,et al.  EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer , 2015, Nature.

[161]  R. Weinberg,et al.  Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression. , 2015, Trends in cell biology.

[162]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[163]  Jun Yao,et al.  Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth , 2015, Nature.

[164]  J. Chen,et al.  Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis , 2015, Cancer science.

[165]  M. Bergo,et al.  Antioxidants can increase melanoma metastasis in mice , 2015, Science Translational Medicine.

[166]  Andrew G. Clark,et al.  Modes of cancer cell invasion and the role of the microenvironment. , 2015, Current opinion in cell biology.

[167]  Stephen T. C. Wong,et al.  EMT is not required for lung metastasis but contributes to chemoresistance , 2016 .

[168]  G. Reid,et al.  Local bacteria affect the efficacy of chemotherapeutic drugs , 2015, Scientific Reports.

[169]  M. Kogevinas,et al.  Night shift work, chronotype and prostate cancer risk in the MCC‐Spain case‐control study , 2015, International journal of cancer.

[170]  F. Xu,et al.  Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance. , 2015, Genetics and molecular research : GMR.

[171]  R. Blackwell,et al.  Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes , 2015, Oncogenesis.

[172]  J. Bayo,et al.  4-methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis. , 2015, Glycobiology.

[173]  K. Polyak,et al.  Tumorigenesis: it takes a village , 2015, Nature Reviews Cancer.

[174]  V. Lokeshwar,et al.  Dietary supplement 4-methylumbelliferone: an effective chemopreventive and therapeutic agent for prostate cancer. , 2015, Journal of the National Cancer Institute.

[175]  Cancer biology: Cancer-cell transfer filmed , 2015, Nature.

[176]  Jacco van Rheenen,et al.  In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior , 2015, Cell.

[177]  Michael A. Hollingsworth,et al.  Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver , 2015, Nature Cell Biology.

[178]  R. Markwald,et al.  Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer , 2015, Front. Immunol..

[179]  Steffen Dickopf,et al.  A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis , 2015, Nature.

[180]  Yan Du,et al.  A novel role of low molecular weight hyaluronan in breast cancer metastasis , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[181]  W. Westbroek,et al.  Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement , 2015, PloS one.

[182]  M. Nykter,et al.  The Evolutionary History of Lethal Metastatic Prostate Cancer , 2015, Nature.

[183]  S. Jonjić,et al.  Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. , 2015, Immunity.

[184]  J. Jonkers,et al.  IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis , 2015, Nature.

[185]  A. Carnero,et al.  Genetic modification of hypoxia signaling in animal models and its effect on cancer , 2015, Clinical and Translational Oncology.

[186]  M. Zöller,et al.  The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding , 2014, Oncotarget.

[187]  F. Maquart,et al.  Lumican: A new inhibitor of matrix metalloproteinase‐14 activity , 2014, FEBS letters.

[188]  Y. Mo,et al.  Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer , 2014, Molecular Cancer.

[189]  Klaus Pantel,et al.  Biology, detection, and clinical implications of circulating tumor cells , 2014, EMBO molecular medicine.

[190]  J. Redzic,et al.  Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro. , 2014, Biochimica et biophysica acta.

[191]  Yali Hou,et al.  The role of GPC5 in lung metastasis of salivary adenoid cystic carcinoma. , 2014, Archives of oral biology.

[192]  S. Chouaib,et al.  Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment , 2014, Cancer Microenvironment.

[193]  Amy E. Robertson,et al.  Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. , 2014, Cell reports.

[194]  Sridhar Ramaswamy,et al.  Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis , 2014, Cell.

[195]  P. Bragado,et al.  Mechanisms of disseminated cancer cell dormancy: an awakening field , 2014, Nature Reviews Cancer.

[196]  Jiang Li,et al.  Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma , 2014, Oncotarget.

[197]  M. Rothley,et al.  Accumulation of small hyaluronan oligosaccharides in tumour interstitial fluid correlates with lymphatic invasion and lymph node metastasis , 2014, British Journal of Cancer.

[198]  T. Burnouf,et al.  Regulation of Tumor Growth and Metastasis: The Role of Tumor Microenvironment , 2014, Cancer growth and metastasis.

[199]  K. O'Byrne,et al.  Functions and Therapeutic Roles of Exosomes in Cancer , 2014, Front. Oncol..

[200]  B. Nieswandt,et al.  Mechanistic explanation for platelet contribution to cancer metastasis. , 2014, Thrombosis research.

[201]  Wenyang Pang,et al.  Thrombocytosis is a significant indictor of hypercoagulability, prognosis and recurrence in gastric cancer , 2014, Experimental and therapeutic medicine.

[202]  J. Filmus,et al.  The role of glypicans in Hedgehog signaling. , 2014, Matrix biology : journal of the International Society for Matrix Biology.

[203]  S. Kondo,et al.  Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes , 2014, Oncogene.

[204]  T. Ørntoft,et al.  Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors , 2014, Proteomics.

[205]  J. Karp,et al.  Mesenchymal stem cells: immune evasive, not immune privileged , 2014, Nature Biotechnology.

[206]  Samy Lamouille,et al.  Molecular mechanisms of epithelial–mesenchymal transition , 2014, Nature Reviews Molecular Cell Biology.

[207]  G. Semenza,et al.  Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. , 2014, Annual review of pathology.

[208]  R. Pink,et al.  Routes and mechanisms of extracellular vesicle uptake , 2014, Journal of extracellular vesicles.

[209]  A. Ridley,et al.  Crossing the endothelial barrier during metastasis , 2013, Nature Reviews Cancer.

[210]  F. Giancotti.  Mechanisms Governing Metastatic Dormancy and Reactivation , 2013, Cell.

[211]  A. Moustakas,et al.  Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells , 2013, PloS one.

[212]  P. Bragado,et al.  TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling , 2013, Nature Cell Biology.

[213]  G. Semenza.  Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis , 2013, Oncogene.

[214]  M. Zöller,et al.  Host matrix modulation by tumor exosomes promotes motility and invasiveness. , 2013, Neoplasia.

[215]  H. Yoshiyama,et al.  Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells , 2013, Journal of Virology.

[216]  S. Offermanns,et al.  Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. , 2013, Cancer cell.

[217]  Mina J. Bissell,et al.  The perivascular niche regulates breast tumor dormancy , 2013, Nature Cell Biology.

[218]  Pier Andrea Nicolosi,et al.  NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion. , 2013, Journal of molecular cell biology.

[219]  L. Uhlin‐Hansen,et al.  Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets , 2013, Tumor Biology.

[220]  F. Maquart,et al.  Lumican effects in the control of tumour progression and their links with metalloproteinases and integrins , 2013, The FEBS journal.

[221]  P. Ratcliffe.  Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer , 2013, The Journal of physiology.

[222]  Yibin Kang,et al.  The metastasis-promoting roles of tumor-associated immune cells , 2013, Journal of Molecular Medicine.

[223]  R. Gray,et al.  Survival in patients with metastatic recurrent breast cancer after adjuvant chemotherapy , 2013, Cancer.

[224]  T. Åkerstedt,et al.  Breast cancer among shift workers: results of the WOLF longitudinal cohort study. , 2013, Scandinavian journal of work, environment & health.

[225]  Sridhar Ramaswamy,et al.  Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition , 2013, Science.

[226]  G. Berx,et al.  Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.

[227]  Samy Lamouille,et al.  TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression , 2013, Current opinion in oncology.

[228]  J. Wrana,et al.  Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration , 2012, Cell.

[229]  W. Stetler-Stevenson,et al.  Matrix metalloproteinases: changing roles in tumor progression and metastasis. , 2012, The American journal of pathology.

[230]  Richard O Hynes,et al.  The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. , 2012, Cancer discovery.

[231]  C. Heldin,et al.  Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2 , 2012, Oncogene.

[232]  Kurt Miller,et al.  Increased survival with enzalutamide in prostate cancer after chemotherapy. , 2012, The New England journal of medicine.

[233]  S. Steinberg,et al.  Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer. , 2012, Journal of the National Cancer Institute.

[234]  A. Brivanlou,et al.  The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites , 2012, Cell.

[235]  R. Kamm,et al.  Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function , 2012, Proceedings of the National Academy of Sciences.

[236]  A. Yee,et al.  The role of versican G3 domain in regulating breast cancer cell motility including effects on osteoblast cell growth and differentiation in vitro – evaluation towards understanding breast cancer cell bone metastasis , 2012, BMC Cancer.

[237]  Paul J Hertzog,et al.  Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape , 2012, Nature Medicine.

[238]  Roberta Galli,et al.  MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response , 2012, Proceedings of the National Academy of Sciences.

[239]  G. Lorusso,et al.  New insights into the mechanisms of organ-specific breast cancer metastasis. , 2012, Seminars in cancer biology.

[240]  Q. Lin,et al.  Expression of GPC3 protein and its significance in lung squamous cell carcinoma , 2012, Medical Oncology.

[241]  Gema Moreno-Bueno,et al.  Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.

[242]  A. Thorburn,et al.  Inhibition of autophagy impairs tumor cell invasion in an organotypic model , 2012, Cell cycle.

[243]  Kwok-Kin Wong,et al.  Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer , 2012, Proceedings of the National Academy of Sciences.

[244]  H. Rammensee,et al.  Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells. , 2012, Cancer research.

[245]  M. Watabe,et al.  Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. , 2012, Cancer research.

[246]  J. Massagué,et al.  VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. , 2011, Cancer cell.

[247]  M. Watabe,et al.  Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone , 2011, The Journal of experimental medicine.

[248]  Robert A. Weinberg,et al.  Tumor Metastasis: Molecular Insights and Evolving Paradigms , 2011, Cell.

[249]  L. Norton,et al.  Tumor entrained neutrophils inhibit seeding in the premetastatic lung. , 2011, Cancer cell.

[250]  M. Mason,et al.  Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production , 2011, The Journal of Immunology.

[251]  I. Fidler,et al.  The seed and soil hypothesis revisited—The role of tumor‐stroma interactions in metastasis to different organs , 2011, International journal of cancer.

[252]  S. Wickline,et al.  Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. , 2011, Cancer research.

[253]  G. Ayers,et al.  Amphiregulin Exosomes Increase Cancer Cell Invasion , 2011, Current Biology.

[254]  D. Lyden,et al.  The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. , 2011, Seminars in cancer biology.

[255]  Sascha Keller,et al.  Interaction and uptake of exosomes by ovarian cancer cells , 2011, BMC Cancer.

[256]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[257]  J. Filmus,et al.  Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling , 2011, The Journal of cell biology.

[258]  Laurie J. Gay,et al.  Contribution of platelets to tumour metastasis , 2011, Nature Reviews Cancer.

[259]  Valerie M. Weaver,et al.  The extracellular matrix at a glance , 2010, Journal of Cell Science.

[260]  P. Goss,et al.  Does tumour dormancy offer a therapeutic target? , 2010, Nature Reviews Cancer.

[261]  Dai Fukumura,et al.  Malignant cells facilitate lung metastasis by bringing their own soil , 2010, Proceedings of the National Academy of Sciences.

[262]  A. Yee,et al.  Versican G3 Promotes Mouse Mammary Tumor Cell Growth, Migration, and Metastasis by Influencing EGF Receptor Signaling , 2010, PloS one.

[263]  D. Schadendorf,et al.  Improved survival with ipilimumab in patients with metastatic melanoma. , 2010, The New England journal of medicine.

[264]  Jing Yang,et al.  Visualizing extravasation dynamics of metastatic tumor cells , 2010, Journal of Cell Science.

[265]  M. Cronin,et al.  Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[266]  D. Chan,et al.  Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation , 2010, BMC Cancer.

[267]  Z. Werb,et al.  Matrix Metalloproteinases: Regulators of the Tumor Microenvironment , 2010, Cell.

[268]  K. Pienta,et al.  GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. , 2010, Neoplasia.

[269]  J. Pollard,et al.  Microenvironmental regulation of metastasis , 2009, Nature Reviews Cancer.

[270]  W. Born,et al.  IL‐17‐producing γδ T cells , 2009, European Journal of Immunology.

[271]  A. Tsatsakis,et al.  Lumican, a small leucine‐rich proteoglycan , 2008, IUBMB life.

[272]  S. Kuriyama,et al.  Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study , 2008, British Journal of Cancer.

[273]  Rakesh K Jain,et al.  Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? , 2007, The Lancet. Oncology.

[274]  J. Massagué,et al.  Genetic determinants of cancer metastasis , 2007, Nature Reviews Genetics.

[275]  C. Overall,et al.  Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A). , 2007, The Biochemical journal.

[276]  P. Steeg.  Tumor metastasis: mechanistic insights and clinical challenges , 2006, Nature Medicine.

[277]  G. Semenza.  VHL and p53: tumor suppressors team up to prevent cancer. , 2006, Molecular cell.

[278]  Kristina Kjærheim,et al.  Breast Cancer and Night Work among Norwegian Nurses , 2006, Cancer Causes & Control.

[279]  W. Gerald,et al.  Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. , 2005, The Journal of clinical investigation.

[280]  Ana M Soto,et al.  The stroma as a crucial target in rat mammary gland carcinogenesis , 2004, Journal of Cell Science.

[281]  W. Hornebeck,et al.  An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion. , 2004, Critical reviews in oncology/hematology.

[282]  D. Welch,et al.  Metastasis suppressor pathways--an evolving paradigm. , 2003, Cancer letters.

[283]  E. Liu,et al.  Genetic background is an important determinant of metastatic potential , 2003, Nature Genetics.

[284]  J. Aguirre-Ghiso,et al.  ERKMAPK Activity as a Determinant of Tumor Growth and Dormancy; Regulation by p38SAPK , 2003 .

[285]  Helmut Burtscher,et al.  Identification of rat pancreatic carcinoma genes associated with lymphogenous metastasis. , 2002, Anticancer research.

[286]  Z. Werb,et al.  New functions for the matrix metalloproteinases in cancer progression , 2002, Nature Reviews Cancer.

[287]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[288]  F Laden,et al.  Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. , 2001, Journal of the National Cancer Institute.

[289]  J. Aguirre-Ghiso,et al.  Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. , 2001, Molecular biology of the cell.

[290]  S. Curran,et al.  Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis. , 2000, European journal of cancer.

[291]  M. Barcellos-Hoff,et al.  Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. , 2000, Cancer research.

[292]  K. Luzzi,et al.  Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. , 1998, The American journal of pathology.

[293]  M. Dewhirst,et al.  Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. , 1996, Cancer research.

[294]  M. Höckel,et al.  Tumor oxygenation: a new predictive parameter in locally advanced cancer of the uterine cervix. , 1993, Gynecologic oncology.

[295]  Yousef Ahmed Fouad,et al.  Revisiting the hallmarks of cancer. , 2017, American journal of cancer research.

[296]  P. Friedl,et al.  Mechanoreciprocity in cell migration , 2017, Nature Cell Biology.

[297]  U. Weidle,et al.  The Multiple Roles of Exosomes in Metastasis. , 2017, Cancer genomics & proteomics.

[298]  E. Bernstein,et al.  Epigenetic Regulation of Cancer Dormancy as a Plasticity Mechanism for Metastasis Initiation , 2017 .

[299]  Jean Paul Thiery,et al.  EMT: 2016 , 2016, Cell.

[300]  R. Matkowski,et al.  Circulating Tumor , 2014 .

[301]  David B Nash,et al.  It takes a village. , 2010, P & T : a peer-reviewed journal for formulary management.

[302]  M. Zöller.  Tetraspanins: push and pull in suppressing and promoting metastasis , 2009, Nature Reviews Cancer.

[303]  A. Mantovani,et al.  Chemokines and chemokine receptors: an overview. , 2009, Frontiers in bioscience.

[304]  Yong-jie Lu,et al.  Role for amplification and expression of glypican-5 in rhabdomyosarcoma. , 2007, Cancer research.

[305]  P. Mahadevan,et al.  An overview , 2007, Journal of Biosciences.

[306]  K. Straif,et al.  Carcinogenicity of shift-work , painting , and fi refi ghting , 2007 .

[307]  G. Collins.  The next generation. , 2006, Scientific American.

[308]  R. Kaplan,et al.  Priming the 'soil' for breast cancer metastasis: the pre-metastatic niche. , 2006, Breast disease.

[309]  E. Lander,et al.  A molecular signature of metastasis in primary solid tumors , 2003, Nature Genetics.

[310]  P. Steeg.  Metastasis suppressors alter the signal transduction of cancer cells , 2003, Nature Reviews Cancer.

[311]  Adrian L. Harris,et al.  Hypoxia — a key regulatory factor in tumour growth , 2002, Nature Reviews Cancer.