Splicing inhibition induces gene expression through canonical NF‐κB pathway and extracellular signal‐related kinase activation

[1]  T. Bonfield,et al.  Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells , 2011, Journal of Inflammation.

[2]  S. Kojima,et al.  Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF , 2010, Cancer science.

[3]  A. S. Shifera,et al.  PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins. , 2009, Archives of biochemistry and biophysics.

[4]  C. Will,et al.  The Spliceosome: Design Principles of a Dynamic RNP Machine , 2009, Cell.

[5]  D. Waugh,et al.  The Interleukin-8 Pathway in Cancer , 2008, Clinical Cancer Research.

[6]  M. Hagiwara,et al.  Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA , 2007, Nature Chemical Biology.

[7]  Jingfeng Li,et al.  Parthenolide Inhibits IκB Kinase, NF-κB Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice , 2007 .

[8]  G. Weber,et al.  Synergistic activation of the CMV promoter by NF-κB P50 and PKG , 2004 .

[9]  P. Brecher,et al.  Temporal Control of NF-κB Activation by ERK Differentially Regulates Interleukin-1β-induced Gene Expression* , 2004, Journal of Biological Chemistry.

[10]  S. Horinouchi,et al.  Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes , 2004, Bioscience, biotechnology, and biochemistry.

[11]  O. Dittrich‐Breiholz,et al.  Multiple control of interleukin‐8 gene expression , 2002, Journal of leukocyte biology.

[12]  P. Bennett,et al.  Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cells. , 2001, Molecular human reproduction.

[13]  J. Metcalf,et al.  Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2 , 2001, Journal of Virology.

[14]  T. Hofmann,et al.  The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex , 1999, The Journal of Immunology.

[15]  S. Horinouchi,et al.  Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase , 1999, Oncogene.

[16]  K. Matsushima,et al.  Human T-Cell Leukemia Virus Type I Tax Transactivates Human Interleukin 8 Gene through Acting Concurrently on AP-1 and Nuclear Factor-κB-like Sites , 1998 .

[17]  Harry F Noller,et al.  Molecular Movement inside the Translational Engine , 1998, Cell.

[18]  M. Okuhara,et al.  New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. , 1997, The Journal of antibiotics.

[19]  M. Okuhara,et al.  New Antitumor Substances, FR901463, FR901464 and FR901465 , 1996 .

[20]  M. Okuhara,et al.  New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. , 1996, The Journal of antibiotics.

[21]  P. Baeuerle,et al.  A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B. , 1994, The EMBO journal.

[22]  H. Volk,et al.  Tumour necrosis factor alpha stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells. , 1993, The Journal of general virology.

[23]  P. Corthésy,et al.  Interleukin 1 and tumor necrosis factor enhance transcription from the SV40 early promoter in a T cell line , 1989, European journal of immunology.

[24]  M. Karin,et al.  Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer , 1986, Nature.

[25]  Jingfeng Li,et al.  Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice. , 2007, American journal of respiratory cell and molecular biology.

[26]  P. Brecher,et al.  Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression. , 2004, Journal of Biological Chemistry.

[27]  G. Weber,et al.  Synergistic activation of the CMV promoter by NF-kappaB P50 and PKG. , 2004, Biochemical and biophysical research communications.

[28]  T. Hofmann,et al.  The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. , 1999, Journal of immunology.

[29]  F. Lee,et al.  Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. , 1999, The Journal of biological chemistry.

[30]  K. Matsushima,et al.  Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites. , 1998, Cancer research.