The Role of Technology in Translational Science

Despite the foundation of the Clinical and Translational Science Award (CTSA) program and the National Center for Advancing Translational Science (NCATS), the process to bring novel tools to the clinical setting is hindered by administrative challenges. Technology offers solutions to these obstacles and has the potential to drive the field of translational science forward. In this commentary, we discuss diagnostic technology, clinical informatics, and bioinformatics and their roles in the development of this field.

[1]  F. Collins Reengineering Translational Science: The Time Is Right , 2011, Science Translational Medicine.

[2]  Lucila Ohno-Machado,et al.  Translational bioinformatics: linking knowledge across biological and clinical realms , 2011, J. Am. Medical Informatics Assoc..

[3]  L. Rice Rapid diagnostics and appropriate antibiotic use. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  G. Dorn MicroRNAs in cardiac disease. , 2011, Translational research : the journal of laboratory and clinical medicine.

[5]  D. Roden,et al.  The Emerging Role of Electronic Medical Records in Pharmacogenomics , 2011, Clinical pharmacology and therapeutics.

[6]  Janice Branson,et al.  Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056 , 2011, Science Translational Medicine.

[7]  Eduardo Gotuzzo,et al.  Rapid molecular detection of tuberculosis and rifampin resistance. , 2010, The New England journal of medicine.

[8]  M. Bergeron,et al.  Diagnosing infections--current and anticipated technologies for point-of-care diagnostics and home-based testing. , 2010, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[9]  Michael Feldman,et al.  caTIES: a grid based system for coding and retrieval of surgical pathology reports and tissue specimens in support of translational research , 2010, J. Am. Medical Informatics Assoc..

[10]  I. Sarkar Biomedical informatics and translational medicine , 2010, Journal of Translational Medicine.

[11]  Frederick L Kiechle,et al.  Point-of-care testing and molecular diagnostics: miniaturization required. , 2009, Clinics in laboratory medicine.

[12]  Maria Elena Bottazzi,et al.  The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination , 2008, PLoS neglected tropical diseases.

[13]  Peter A. Bath,et al.  Health informatics: current issues and challenges , 2008, J. Inf. Sci..

[14]  S. Woolf The meaning of translational research and why it matters. , 2008, JAMA.

[15]  Alex Rhee,et al.  Convergence of quantum dot barcodes with microfluidics and signal processing for multiplexed high-throughput infectious disease diagnostics. , 2007, Nano letters.

[16]  J. Westfall,et al.  Practice-based research--"Blue Highways" on the NIH roadmap. , 2007, JAMA.

[17]  Francis S Collins,et al.  Realizing the promise of genomics in biomedical research. , 2005, JAMA.

[18]  E Ray Dorsey,et al.  Financial anatomy of biomedical research. , 2005, JAMA.

[19]  Samuel Yang,et al.  PCR-based diagnostics for infectious diseases: uses, limitations, and future applications in acute-care settings , 2004, The Lancet Infectious Diseases.

[20]  David A. Williams,et al.  Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts , 2004, Nature.

[21]  A. Hagège,et al.  Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. , 2003, Journal of the American College of Cardiology.

[22]  Stephen B. Johnson,et al.  Central challenges facing the national clinical research enterprise. , 2003, JAMA.