Discrete modeling of aggressive tumor growth with gradual effect of chemotherapy

Abstract Discrete mathematical models are proposed to study the dynamics of interacting cells of an organism that is affected by an aggressive heterogeneous tumor. The models include the application of a chemotherapy treatment with a gradual effect. Another factor included in the models is the competence among the different tumor cells. An effective treatment index is introduced in order to analyze the evolution of the tumor and to compare different treatments.

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