LCH, also formerly known as eosinophilic granuloma or histiocytosis X, is characterized by impairment of the structure and functions of normal tissues by abnormal proliferation of Langerhans cells. We report and discuss here isolated pulmonary Langerhans cell histiocytosis (LCH) with recent literature. Our patient is a 28-year-old male man who has been complaining of cough, shortness of breath, chest pain and weight loss for three months. Thoracic computerized tomography (CT) showed partial pneumothorax on the right, bilateral parenchymal cystic spaces and accompanying pericystic reticular pattern. Bronchoscopy was normal and bronchoalveolar lavage sample was non-specific. Videothoracoscopic wedge biopsy was performed and the immunohistochemical examination showed LCH. No sign of extra-pulmona ry involvement was found in the patient's body screening. Our patient was accepted as isolated pulmonary LCH. He was treated only by to quit smoking and there is no evidence of progression since six months. (Anatol J Clin Investig 2008:2(3);127-129). Ozet Eozinofilik granulom yada histiositozis X olarak ta bilinen Langerhans hucreli histiositozis (LHH) pigment icermeyen dendritik hucrelerin, normal hucrelerin yapi ve fonksiyonlarini bozmasi ile karakterizedir. Izole langerhans hucreli histiositozs tanisi koydugumuz hastamizi literatut e sliginde sunmayi amacladik. Uc aydir devam eden oksuruk, nefes darligi, gogus agrisi, kilo kaybi sikayeti basvuran 28 yasindaki erkek hastada cekilen toraks bilgisayarli tomografisinde (BT); sagda minimal pnomotoraks, her iki akciger parankiminde interstisyel ve interlobuler septal yapilarda yer yer kucuk kistik belirginlesmeler, minimal bronsiektazi ve eslik eden peribronsiyal kalinlasmalar saptandi. Bronkoskopisi dogal ve bronkoalveoler lavaj ornegi nonspesifik olarak degerlendirildi.. Videotorakoskopik wedge biyopsi uygulandi ve patolojik inceleme Langerhans hucreli histiositozis olarak sonuclandi. Yapilan taramalarda ekstrapulmoner tutuluma ait bulgu saptanmadi. Hastaya sigara biraktirildi ve 6 aylik takibinde hastaligin ilerledigine ait bulguya rastlanmadi. (Anatol J Clin Investig 2008:2(3);127-129).
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