The analysis of hypervariable DNA profiles: problems associated with the objective determination of the probability of a match

SummaryA computerised system has been used to store DNA profiles from 3 hypervariable loci. This initial survey illustrates that band matching is only possible after analysis of the errors associated with electrophoretic systems. A number of databases have been constructed with the three probes investigated and two methods of frequency determination, ‘binning’ and ‘sliding window’ fitting, have been compared.

[1]  David J. Werrett,et al.  An evaluation of DNA fingerprinting for forensic purposes , 1987 .

[2]  P Rubinstein,et al.  Allele frequency distribution of two highly polymorphic DNA sequences in three ethnic groups and its application to the determination of paternity. , 1986, American journal of human genetics.

[3]  R. White,et al.  A highly polymorphic locus in human DNA. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[4]  David J. Werrett,et al.  Forensic application of DNA ‘fingerprints’ , 1985, Nature.

[5]  W. Rutter,et al.  The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences , 1982, Nature.

[6]  Swee Lay Thein,et al.  Hypervariable ‘minisatellite’ regions in human DNA , 1985, Nature.

[7]  T. Maniatis,et al.  The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene , 1982, Cell.

[8]  G. Church,et al.  Genomic sequencing. , 1993, Methods in molecular biology.

[9]  A. Jeffreys,et al.  Characterization of a panel of highly variable minisatellites cloned from human DNA , 1987, Annals of human genetics.

[10]  Y. Nakamura,et al.  A mapped set of DNA markers for human chromosome 17. , 1988, Genomics.

[11]  Y. Nakamura,et al.  Variable number of tandem repeat (VNTR) markers for human gene mapping. , 1987, Science.

[12]  P I Terasaki,et al.  Calculation of probability of paternity using DNA sequences. , 1988, American journal of human genetics.

[13]  Alun Anderson,et al.  DNA fingerprinting on trial , 1989, Nature.

[14]  I. W. EVETT,et al.  DNA fingerprinting on trial , 1989, Nature.