The splice variants of vascular endothelial growth factor (VEGF) and their receptors.
暂无分享,去创建一个
[1] A. Eichmann,et al. Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[2] K. Alitalo,et al. Vascular endothelial growth factor C induces angiogenesis in vivo. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[3] H. Dvorak,et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. , 1983, Science.
[4] S. Soker,et al. The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. , 1992, The Journal of biological chemistry.
[5] K. Alitalo,et al. Genomic Organization of the Mouse and Human Genes for Vascular Endothelial Growth Factor B (VEGF-B) and Characterization of a Second Splice Isoform* , 1996, The Journal of Biological Chemistry.
[6] J. Winer,et al. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. , 1992, The Journal of biological chemistry.
[7] Y. Hirata,et al. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. , 1997, Genomics.
[8] A. N. Corps,et al. A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. , 1998, Biology of reproduction.
[9] D. Gospodarowicz,et al. VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor. , 1994, Growth factors.
[10] G. Martiny-Baron,et al. The α-Helical Domain Near the Amino Terminus Is Essential for Dimerization of Vascular Endothelial Growth Factor* , 1998, The Journal of Biological Chemistry.
[11] T. Sawada,et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma , 1996, Cancer.
[12] T. Kitsukawa,et al. Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. , 1995, Development.
[13] K. Alitalo,et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[14] Mikyoung Park,et al. The fourth immunoglobulin-like loop in the extracellular domain of FLT-1, a VEGF receptor, includes a major heparin-binding site. , 1999, Biochemical and biophysical research communications.
[15] B. Li,et al. Requirements for Binding and Signaling of the Kinase Domain Receptor for Vascular Endothelial Growth Factor* , 1998, The Journal of Biological Chemistry.
[16] M. Shibuya,et al. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. , 1995, Oncogene.
[17] D. Gospodarowicz,et al. Transcriptional regulation of vascular endothelial growth factor gene expression in ovarian bovine granulosa cells. , 1993, Growth factors.
[18] T. Noda,et al. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[19] H. Weich,et al. A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. , 1993, Growth factors.
[20] K. Alitalo,et al. A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases. , 1996, The EMBO journal.
[21] D. Connolly,et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. , 1989, Science.
[22] G. Semenza,et al. Structural and functional analysis of hypoxia-inducible factor 1. , 1997, Kidney international.
[23] J. Park,et al. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. , 1993, Molecular biology of the cell.
[24] Georg Breier,et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo , 1992, Nature.
[25] P. Welker,et al. Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206. , 1998, Molecular biology of the cell.
[26] D. Connolly,et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration , 1990, The Journal of experimental medicine.
[27] Atsushi Namiki,et al. Indirect Angiogenic Cytokines Upregulate VEGF and bFGF Gene Expression in Vascular Smooth Muscle Cells, Whereas Hypoxia Upregulates VEGF Expression Only , 1994 .
[28] H. Cai,et al. Cloning and Characterization of Neuropilin-1-Interacting Protein: A PSD-95/Dlg/ZO-1 Domain-Containing Protein That Interacts with the Cytoplasmic Domain of Neuropilin-1 , 1999, The Journal of Neuroscience.
[29] M. Shibuya,et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[30] R. Brace,et al. Vascular endothelial growth factor gene expression in ovine placenta and fetal membranes. , 1995, American journal of obstetrics and gynecology.
[31] Lieve Moons,et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.
[32] S. Stringer,et al. Heparan sulphate. , 1997, The international journal of biochemistry & cell biology.
[33] S. Soker,et al. Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells. , 1996, The Journal of biological chemistry.
[34] B. Keyt,et al. Homologous Up-regulation of KDR/Flk-1 Receptor Expression by Vascular Endothelial Growth Factor in Vitro * , 1998, The Journal of Biological Chemistry.
[35] B. Olffson. Vascular endothelial grouth facter B, a novel growth facter for endothelial cells , 1996 .
[36] J. Winer,et al. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. , 1991, Molecular endocrinology.
[37] G. Viglietto,et al. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[38] K. Alitalo,et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. , 1994, The Journal of biological chemistry.
[39] W. Hendrickson,et al. A structural superfamily of growth factors containing a cystine knot motif , 1993, Cell.
[40] I. Zachary. Vascular Endothelial Growth Factor: How It Transmits Its Signal , 1998, Nephron Experimental Nephrology.
[41] H Ueno,et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. , 1992, Science.
[42] M. Tessier-Lavigne,et al. Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III , 1997, Cell.
[43] M. Goldberg,et al. Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia (*) , 1995, The Journal of Biological Chemistry.
[44] B. Keyt,et al. Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors , 1996, The Journal of Biological Chemistry.
[45] P. Pollock,et al. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. , 1996, Genome research.
[46] G. Neufeld,et al. VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix* , 1997, The Journal of Biological Chemistry.
[47] L. Orci,et al. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. , 1991, Biochemical and biophysical research communications.
[48] K. Alitalo,et al. Vascular endothelial growth factor (VEGF)‐C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity , 1998, Journal of cellular physiology.
[49] S. Oliviero,et al. 血小板由来増殖因子/血管内皮増殖因子ファミリーと相関するc‐fos誘導性遺伝子の同定 , 1996 .
[50] S. Soker,et al. Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility , 1999, The Journal of cell biology.
[51] I. Zachary. Vascular endothelial growth factor. , 1998, The international journal of biochemistry & cell biology.
[52] B. Keyt,et al. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. , 1996, The Journal of clinical investigation.
[53] J. Folkman. What is the evidence that tumors are angiogenesis dependent? , 1990, Journal of the National Cancer Institute.
[54] R. Linhardt,et al. Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor. , 1997, Growth Factors.
[55] W. Kaelin,et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[56] E. Kremmer,et al. Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1* , 1997, The Journal of Biological Chemistry.
[57] G. Goodall,et al. Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements. , 1999, Molecular biology of the cell.
[58] J. Stone,et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity , 1995, Nature Medicine.
[59] B. Spiegelman,et al. Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF. , 1995, Biochimica et biophysica acta.
[60] H. Augustin,et al. A novel vascular endothelial growth factor encoded by Orf virus, VEGF‐E, mediates angiogenesis via signalling through VEGFR‐2 (KDR) but not VEGFR‐1 (Flt‐1) receptor tyrosine kinases , 1999, The EMBO journal.
[61] S. Oliviero,et al. Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[62] Shay Soker,et al. Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor , 1998, Cell.
[63] G. Semenza,et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.
[64] N. Voelkel,et al. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. , 1995, The Journal of clinical investigation.
[65] K. Alitalo,et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. , 1996, The EMBO journal.
[66] M. Shibuya,et al. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. , 1994, The Journal of biological chemistry.
[67] K. Alitalo,et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[68] Jianxun Lei,et al. Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183. , 1998, Biochimica et biophysica acta.
[69] Charles Eigenbrot,et al. Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor , 1997, Cell.
[70] Y. Cao,et al. Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. , 1997, Biochemical and biophysical research communications.
[71] G. Martiny-Baron,et al. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. , 1996, Cancer research.
[72] C. Goodman,et al. Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III , 1997, Neuron.
[73] N. Ferrara,et al. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. , 1989, Biochemical and biophysical research communications.
[74] Yihai Cao,et al. Proteolytic processing regulates receptor specificity and activity of VEGF‐C , 1997, The EMBO journal.
[75] M. Toi,et al. Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer , 1994, Japanese journal of cancer research : Gann.
[76] A. Giaccia,et al. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. , 1996, Cancer research.
[77] Hung V. Nguyen,et al. The Carboxyl-terminal Domain(111165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency (*) , 1996, The Journal of Biological Chemistry.
[78] R. Kendall,et al. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[79] N. Ferrara,et al. Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes , 1997, The Journal of Biological Chemistry.
[80] B. Keyt,et al. Solution structure of the heparin-binding domain of vascular endothelial growth factor. , 1998, Structure.
[81] M. Persico. Placenta Growth Factor , 2001 .
[82] L. Jingjing,et al. Human Müller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor. , 1999, Investigative ophthalmology & visual science.
[83] P. Sun,et al. The cystine-knot growth-factor superfamily. , 1995, Annual review of biophysics and biomolecular structure.
[84] M. Merrill,et al. Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues. , 1995, Growth factors.
[85] D. Connolly,et al. Identification, Purification, and Characterization of Cell-surface Retention Sequence-binding Proteins from Human SK-Hep Cells and Bovine Liver Plasma Membranes (*) , 1995, The Journal of Biological Chemistry.
[86] L. Williams,et al. A Novel Promoter for Vascular Endothelial Growth Factor Receptor (flt-1) That Confers Endothelial-specific Gene Expression (*) , 1995, The Journal of Biological Chemistry.
[87] K. Alitalo,et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. , 1998, Science.
[88] Shay Soker,et al. Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF via Its Exon 7-encoded Domain (*) , 1996, The Journal of Biological Chemistry.
[89] D. Hicklin,et al. Heparin modulates the interaction of VEGF165 with soluble and cell associated flk-1 receptors. , 1994, The Journal of biological chemistry.
[90] D. Hanahan,et al. Switch to the angiogenic phenotype during tumorigenesis. , 1991, Princess Takamatsu symposia.
[91] G. Semenza,et al. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. , 1996, The American journal of physiology.
[92] J. Gallagher,et al. Molecules in focus: heparan sulphate , 1997 .
[93] Shu-Yun Le,et al. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription , 1998, Oncogene.
[94] G. Breier,et al. The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities , 1996, The Journal of Biological Chemistry.
[95] D. Goeddel,et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. , 1989, Science.
[96] G. Neufeld,et al. Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF121 and VEGF165 Using Several Concurrent Mechanisms (*) , 1995, The Journal of Biological Chemistry.
[97] W. Wood,et al. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[98] U. Hellman,et al. Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1* , 1999, The Journal of Biological Chemistry.
[99] P. Gleizes,et al. Cell Release of Bioactive Fibroblast Growth Factor 2 by Exon 6-encoded Sequence of Vascular Endothelial Growth Factor* , 1997, The Journal of Biological Chemistry.
[100] S. Soker,et al. Vascular endothelial growth factor is inactivated by binding to alpha 2-macroglobulin and the binding is inhibited by heparin. , 1993, The Journal of biological chemistry.
[101] T. Veikkola,et al. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[102] V. Hombach,et al. Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. , 1996, Circulation.
[103] M. Rocchi,et al. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. , 1996, Circulation.
[104] G. Martiny-Baron,et al. VEGF121 induces proliferation of vascular endothelial cells and expression of flk-1 without affecting lymphatic vessels of chorioallantoic membrane. , 1996, Developmental biology.
[105] E. Bauer,et al. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells , 1992, Journal of cellular physiology.
[106] L. Aiello,et al. Comparative Analysis of Vascular Endothelial Growth Factor Receptors on Retinal and Aortic Vascular Endothelial Cells , 1995, Diabetes.
[107] D. Mukhopadhyay,et al. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity , 1997, Molecular and cellular biology.
[108] K. Alitalo,et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia , 1997, Oncogene.
[109] K. Alitalo,et al. Signaling via vascular endothelial growth factor receptors. , 1999, Experimental cell research.
[110] D. Connolly,et al. Human vascular permeability factor. Isolation from U937 cells. , 1989, The Journal of biological chemistry.
[111] L. Aiello,et al. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. , 1996, Investigative ophthalmology & visual science.
[112] G. Lundborg,et al. Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System , 1999, The Journal of Neuroscience.
[113] J. Peng,et al. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. , 1999, Development.
[114] G. Martiny-Baron,et al. An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[115] L. Kjellén,et al. Regulated Diversity of Heparan Sulfate* , 1998, The Journal of Biological Chemistry.
[116] R. Kendall,et al. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. , 1996, Biochemical and biophysical research communications.
[117] A Shinkai,et al. Mapping of the Sites Involved in Ligand Association and Dissociation at the Extracellular Domain of the Kinase Insert Domain-containing Receptor for Vascular Endothelial Growth Factor* , 1998, The Journal of Biological Chemistry.
[118] J. Schneider-Mergener,et al. Vascular Endothelial Growth Factor (VEGF) Receptor II-derived Peptides Inhibit VEGF* , 1999, The Journal of Biological Chemistry.
[119] K. Alitalo,et al. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[120] E. Keshet,et al. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[121] R. Kendall,et al. Specificity of vascular endothelial cell growth factor receptor ligand binding domains. , 1994, Biochemical and biophysical research communications.
[122] W. Kolch,et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. , 1994, Oncogene.
[123] D. Merberg,et al. Molecular cloning of murine FLT and FLT4. , 1993, Oncogene.
[124] G. Conn,et al. Purification and Characterization of a Naturally Occurring Vascular Endothelial Growth Factor · Placenta Growth Factor Heterodimer (*) , 1995, The Journal of Biological Chemistry.
[125] L. Williams,et al. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[126] V. Praloran,et al. [Mitogenic activity of vasculotropin for peripheral human lymphocytes]. , 1991, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.
[127] M. Shibuya,et al. Neuropilin-1 Is a Placenta Growth Factor-2 Receptor* , 1998, The Journal of Biological Chemistry.
[128] N. Sheibani,et al. Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype. , 1998, Molecular biology of the cell.
[129] G. Martiny-Baron,et al. Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. , 1997, Cancer research.
[130] E. Haber,et al. Cloning and Functional Analysis of the Promoter for KDR/flk-1, a Receptor for Vascular Endothelial Growth Factor(*) , 1995, The Journal of Biological Chemistry.
[131] Ulf Eriksson,et al. Vascular endothelial growth factors VEGF‐B and VEGF‐C , 1997, Journal of cellular physiology.
[132] B Z Levi,et al. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells , 1995, The Journal of Biological Chemistry.
[133] D. Gospodarowicz,et al. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[134] P. Romeo,et al. Neuropilin-1 is expressed on bone marrow stromal cells: a novel interaction with hematopoietic cells? , 1999, Blood.
[135] D. Dimitrov,et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. , 1992, Biochemical and biophysical research communications.
[136] S. Soker,et al. Tumor Necrosis Factor-α Regulates Expression of Vascular Endothelial Growth Factor Receptor-2 and of Its Co-receptor Neuropilin-1 in Human Vascular Endothelial Cells* , 1998, The Journal of Biological Chemistry.
[137] J. Isner,et al. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. , 1998, The American journal of pathology.
[138] A. Mantovani,et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. , 1996, Blood.
[139] T. Kitsukawa,et al. Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. , 1996, Journal of neurobiology.
[140] Janet Rossant,et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice , 1995, Nature.
[141] J. Caro,et al. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. , 1996, Archives of biochemistry and biophysics.
[142] K. Igarashi,et al. Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2. , 1998, Biochemical and biophysical research communications.
[143] D. Mukhopadhyay,et al. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. , 1995, Cancer research.
[144] T. Yagi,et al. Neuropilin–Semaphorin III/D-Mediated Chemorepulsive Signals Play a Crucial Role in Peripheral Nerve Projection in Mice , 1997, Neuron.
[145] A. Mercer,et al. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus , 1994, Journal of virology.
[146] S. Takagi,et al. Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. , 1995, Developmental biology.
[147] K. Alitalo,et al. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. , 1992, Cancer research.
[148] T. Blundell,et al. Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. , 1993, Structure.
[149] R. Jain,et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. , 1997, Science.
[150] G. Sachs,et al. Two Functional Forms of Vascular Endothelial Growth Factor Receptor-2/Flk-1 mRNA Are Expressed in Normal Rat Retina* , 1998, The Journal of Biological Chemistry.
[151] A. Karsan,et al. Signaling pathways induced by vascular endothelial growth factor (review). , 2000, International journal of molecular medicine.
[152] L. Brown,et al. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. , 1996, The American journal of physiology.
[153] J. Folkman,et al. Angiogenesis and angiogenesis inhibition: an overview. , 1997, EXS.
[154] E. Keshet,et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis , 1992, Nature.
[155] K. Dutt,et al. Vasculotropin/Vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultued in vitro , 1995, Journal of cellular physiology.
[156] A. Ullrich,et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis , 1993, Cell.
[157] Alex L Kolodkin,et al. Neuropilin Is a Semaphorin III Receptor , 1997, Cell.
[158] M. Shibuya,et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. , 1990, Oncogene.
[159] G. Neufeld,et al. Glypican-1 Is a VEGF165 Binding Proteoglycan That Acts as an Extracellular Chaperone for VEGF165 * , 1999, The Journal of Biological Chemistry.
[160] Alex L Kolodkin,et al. Neuropilin-2 Is a Receptor for Semaphorin IV Insight into the Structural Basis of Receptor Function and Specificity , 1998, Neuron.
[161] D. Connolly,et al. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin. , 1990, The Journal of biological chemistry.
[162] D. Gospodarowicz,et al. Glycosylation of vascular endothelial growth factor is not required for its mitogenic activity. , 1992, Biochemical and biophysical research communications.
[163] M. Shibuya,et al. A Novel Type of Vascular Endothelial Growth Factor, VEGF-E (NZ-7 VEGF), Preferentially Utilizes KDR/Flk-1 Receptor and Carries a Potent Mitotic Activity without Heparin-binding Domain* , 1998, The Journal of Biological Chemistry.
[164] S. Soker,et al. Selective Binding of VEGF to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells (*) , 1996, The Journal of Biological Chemistry.
[165] L. Presta,et al. The second immunoglobulin‐like domain of the VEGF tyrosine kinase receptor Flt‐1 determines ligand binding and may initiate a signal transduction cascade. , 1996, The EMBO journal.
[166] D. Charnock-Jones,et al. Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity. , 1999, Molecular endocrinology.
[167] Yihai Cao,et al. Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1 , 1998, Oncogene.
[168] A. Levy,et al. Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR* , 1998, The Journal of Biological Chemistry.
[169] K. Plate,et al. Putative Control of Angiogenesis in Hemangioblastomas by the von Hippel‐Lindau Tumor Suppressor Gene , 1997, Journal of neuropathology and experimental neurology.
[170] K. Alitalo,et al. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. , 1996, Development.
[171] J. Winer,et al. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. , 1994, The Journal of biological chemistry.
[172] R. Eddy,et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. , 1991, Oncogene.
[173] J. Isner,et al. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. , 1995, Circulation.
[174] J. Rossant,et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium , 1995, Nature.
[175] J. Keiser,et al. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. , 1998, Circulation research.
[176] V. Vincenti,et al. Structure, expression and receptor-binding properties of placenta growth factor (PlGF). , 1999, Current topics in microbiology and immunology.
[177] N. Ferrara,et al. The biology of vascular endothelial growth factor. , 1997, Endocrine reviews.
[178] Kenneth J. Hillan,et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.
[179] S. Kaul,et al. A Novel Alternatively Spliced Form of Murine Vascular Endothelial Growth Factor, VEGF 115* , 1998, The Journal of Biological Chemistry.
[180] P. Nawroth,et al. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[181] T. Quinn,et al. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[182] D. Marmé,et al. Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells (*) , 1995, The Journal of Biological Chemistry.
[183] J. Caro,et al. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. , 1994, Laboratory investigation; a journal of technical methods and pathology.
[184] J. Flanagan,et al. Heterodimers of Placenta Growth Factor/Vascular Endothelial Growth Factor , 1996, The Journal of Biological Chemistry.
[185] S. Mandriota,et al. Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells. , 1998, Experimental cell research.
[186] P. Einat,et al. Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia , 1998, Molecular and Cellular Biology.
[187] D. Maglione. Persico MG.Isolation of a human placenta cDNA coding for a potein related to the vascular premeability factor , 1991 .
[188] N. Copeland,et al. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[189] B. Keyt,et al. The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding. , 1997, Structure.
[190] B. Spiegelman,et al. Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. , 1992, The Journal of biological chemistry.
[191] G. Viglietto,et al. Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. , 1993, Oncogene.
[192] P. Curtin,et al. A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[193] S. Kourembanas,et al. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. , 1995, Circulation research.
[194] F. Bayard,et al. Extracellular Cleavage of the Vascular Endothelial Growth Factor 189-Amino Acid Form by Urokinase Is Required for Its Mitogenic Effect* , 1997, The Journal of Biological Chemistry.
[195] C. Heldin,et al. Identification of a 190-kDa Vascular Endothelial Growth Factor 165 Cell Surface Binding Protein on a Human Glioma Cell Line* , 1997, The Journal of Biological Chemistry.
[196] D. Gospodarowicz,et al. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT‐20 cells. , 1989, The EMBO journal.
[197] S. Soker,et al. Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells. , 1998, The Journal of biological chemistry.
[198] M. A. Pickett,et al. Short report: identification of a specific pattern of vascular endothelial growth factor mRNA expression in human placenta and cultured placental fibroblasts. , 1994, Placenta.
[199] D. Ruiter,et al. Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations. , 1994, The Journal of biological chemistry.
[200] F. Piehl,et al. Restricted expression pattern of vegf-d in the adult and fetal mouse: high expression in the embryonic lung. , 1999, Biochemical and biophysical research communications.
[201] J. Fiddes,et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. , 1991, The Journal of biological chemistry.
[202] D. Mukhopadhyay,et al. The von Hippel-Lindau Gene Product Inhibits Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Renal Cell Carcinoma by Blocking Protein Kinase C Pathways* , 1997, The Journal of Biological Chemistry.
[203] J. Flanagan,et al. Interactions between the Flk-1 receptor, vascular endothelial growth factor, and cell surface proteoglycan identified with a soluble receptor reagent. , 1995, Growth factors.
[204] M. Shibuya,et al. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts , 1997, Oncogene.