Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

This corrects the article DOI: 10.1038/onc.2016.243

[1]  S C West,et al.  BRCA2: a universal recombinase regulator , 2007, Oncogene.

[2]  J. Sale,et al.  PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40. , 2008, Molecular cell.

[3]  David T. W. Jones,et al.  Signatures of mutational processes in human cancer , 2013, Nature.

[4]  D. Branzei,et al.  Ubiquitin family modifications and template switching , 2011, FEBS letters.

[5]  Gábor E. Tusnády,et al.  Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut , 2017, BMC Bioinformatics.

[6]  Feng Zhang,et al.  PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response , 2009, Current Biology.

[7]  J. Sale,et al.  REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo , 2008, Nucleic acids research.

[8]  M. Jasin,et al.  Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. , 2015, Cold Spring Harbor perspectives in biology.

[9]  M. Meuth,et al.  Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1 , 2010, Molecular biology of the cell.

[10]  S. Jentsch,et al.  A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation , 2006, PLoS biology.

[11]  A. Richardson,et al.  BRCA1 haploinsufficiency for replication stress suppression in primary cells , 2014, Nature Communications.

[12]  A. Egashira,et al.  Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 , 2011, Cell.

[13]  Z. Szallasi,et al.  Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. , 2012, Cancer discovery.

[14]  M. Wyatt,et al.  Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. , 2006, Chemical research in toxicology.

[15]  G. Mills,et al.  Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer , 2012, British Journal of Cancer.

[16]  G. Wider,et al.  Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis , 2005, Science.

[17]  This work is licensed under a Creative Commons Attribution-NonCommercial- NoDerivs 3.0 Licence. To view a copy of the licence please see: http://creativecommons.0rg/licenses/by-nc-nd/3.0/ INEQIMTES IN THE DELIVERY OF SERVICES TO A FEMALE FARM CLIENTELE: SOME~~ , 2010 .

[18]  B. Orelli,et al.  RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. , 2007, Cancer research.

[19]  T. Lindahl,et al.  Repair of endogenous DNA damage. , 2000, Cold Spring Harbor symposia on quantitative biology.

[20]  V. Yamazaki,et al.  A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage , 2000, Current Biology.

[21]  A. Venkitaraman,et al.  Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51 , 2008, Nature Structural &Molecular Biology.

[22]  T. Lindahl,et al.  Nonenzymatic methylation of DNA by the intracellular methyl group donor S‐adenosyl‐L‐methionine is a potentially mutagenic reaction. , 1982, The EMBO journal.

[23]  M. Takata,et al.  Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[24]  T. Krude,et al.  Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage , 2004, Journal of Cell Science.

[25]  N. Van Larebeke,et al.  Endogenous DNA damage in humans: a review of quantitative data. , 2004, Mutagenesis.

[26]  J. Sale.  Translesion DNA synthesis and mutagenesis in eukaryotes. , 2013, Cold Spring Harbor perspectives in biology.

[27]  M. DePristo,et al.  The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. , 2010, Genome research.

[28]  J. Sale,et al.  Role for RAD18 in Homologous Recombination in DT40 Cells , 2006, Molecular and Cellular Biology.

[29]  E. Rogakou,et al.  DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139* , 1998, The Journal of Biological Chemistry.

[30]  J. George,et al.  BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  B. Kaina,et al.  DNA breaks and chromosomal aberrations arise when replication meets base excision repair , 2014, The Journal of cell biology.

[32]  A. Vincent-Salomon,et al.  Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. , 2012, Cancer research.

[33]  G. Pfeifer.  Mutagenesis at methylated CpG sequences. , 2006, Current topics in microbiology and immunology.

[34]  S. Iwai,et al.  Analysis of CPD Ultraviolet Lesion Bypass in Chicken DT40 Cells: Polymerase η and PCNA Ubiquitylation Play Identical Roles , 2012, PloS one.

[35]  F. Gergely,et al.  BRCA1-independent ubiquitination of FANCD2. , 2003, Molecular cell.

[36]  T. Halazonetis,et al.  Genomic instability — an evolving hallmark of cancer , 2010, Nature Reviews Molecular Cell Biology.

[37]  B. Strauss,et al.  A model for replication repair in mammalian cells. , 1976, Journal of molecular biology.

[38]  Michael C. Rusch,et al.  CREST maps somatic structural variation in cancer genomes with base-pair resolution , 2011, Nature Methods.

[39]  Olufunmilayo I. Olopade,et al.  Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations , 2007, Nature Reviews Cancer.

[40]  Nicolai J. Birkbak,et al.  Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy. , 2015, Cancer discovery.

[41]  D. Sheer,et al.  The role of microhomology in genomic structural variation. , 2014, Trends in genetics : TIG.

[42]  Hiroyuki Konishi,et al.  Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells , 2011, Proceedings of the National Academy of Sciences.

[43]  A. Richardson,et al.  Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence , 2015, Nature Communications.

[44]  L. Loeb,et al.  Human cancers express mutator phenotypes: origin, consequences and targeting , 2011, Nature Reviews Cancer.

[45]  Andrew Menzies,et al.  Subclonal diversification of primary breast cancer revealed by multiregion sequencing , 2015, Nature Medicine.

[46]  T. Helleday,et al.  Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks , 2005, Nucleic acids research.

[47]  W. Sakai,et al.  The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination , 2011, PLoS genetics.

[48]  G. Mills,et al.  Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2 , 2002, International journal of cancer.

[49]  D. Livingston,et al.  BRCA1 is required for postreplication repair after UV-induced DNA damage. , 2011, Molecular cell.

[50]  Ira M. Hall,et al.  SAMBLASTER: fast duplicate marking and structural variant read extraction , 2014, Bioinform..

[51]  C. Shaw,et al.  Mus81 and converging forks limit the mutagenicity of replication fork breakage , 2015, Science.

[52]  J. Buerstedde,et al.  Light chain gene conversion continues at high rate in an ALV‐induced cell line. , 1990, The EMBO journal.

[53]  Zhihui Feng,et al.  A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest , 2011, Nucleic acids research.

[54]  A. Børresen-Dale,et al.  Mutational Processes Molding the Genomes of 21 Breast Cancers , 2012, Cell.

[55]  Gábor E. Tusnády,et al.  The Genome of the Chicken DT40 Bursal Lymphoma Cell Line , 2014, G3: Genes, Genomes, Genetics.