Prenatal Mercury Exposure in Pregnant Women from Suriname’s Interior and Its Effects on Birth Outcomes

Prenatal mercury (Hg) exposure was determined in a sub-cohort of the Caribbean Consortium for Environmental and Occupational Health’s environmental epidemiologic prospective cohort study of pregnant women living in Suriname’s interior. The associations between Hg exposure, low birth weight (LBW, <2500 g) and preterm birth (PTB, <37 weeks) were explored. Correlation analysis, Fisher’s exact test and logistic regression analyses were conducted to evaluate the associations between maternal hair Hg levels and birth weight, LBW and PTB, and between potential confounders, LBW and PTB, respectively. Among 204 singleton births were 198 live births, five stillbirths and one miscarriage. The mean participant age was 26 years; 15.7% of participants had PTBs and 8.1% delivered a child with a LBW. The median hair Hg level was 3.48 μg/g hair. Low hair Hg exposure, based on lowest tertile < 2.34 μg/g, was associated with LBW (OR = 7.2; 95% CI 1.5–35.6; p = 0.015); this association was independent of maternal age, ethnic background, household income and village location, and no correlation was found between hair Hg and PTB. Young maternal age was associated with PTB (RR = 5.09, 95% CI: 1.92–13.85; p = 0.0004) while maternal age was not associated with hair Hg or LBW. The impact of prenatal Hg exposure on pediatric neurodevelopment is currently being evaluated in the infant sub-cohort.

[1]  B. Mol,et al.  Association between fetal sex, birthweight percentile and adverse pregnancy outcome , 2019, Acta obstetricia et gynecologica Scandinavica.

[2]  Y. Saijo,et al.  Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort. , 2019, Environment international.

[3]  C. Bramante,et al.  Fish Consumption During Pregnancy: An Opportunity, Not a Risk. , 2018, JAMA pediatrics.

[4]  M. Lichtveld,et al.  Mercury Levels in Women and Children from Interior Villages in Suriname, South America , 2018, International journal of environmental research and public health.

[5]  B. Hamilton,et al.  Births : provisional data for 2017 , 2018 .

[6]  J. Golding,et al.  A review of guidance on fish consumption in pregnancy: is it fit for purpose? , 2018, Public Health Nutrition.

[7]  K. Ohtani,et al.  Prenatal mercury exposure and birth weight. , 2018, Reproductive toxicology.

[8]  A. Sarker,et al.  Distribution and Determinants of Low Birth Weight in Developing Countries , 2016, Journal of preventive medicine and public health = Yebang Uihakhoe chi.

[9]  A. Tardón,et al.  Prenatal mercury exposure and birth outcomes. , 2016, Environmental research.

[10]  J. Golding,et al.  Blood mercury levels and fish consumption in pregnancy: Risks and benefits for birth outcomes in a prospective observational birth cohort , 2016, International journal of hygiene and environmental health.

[11]  Tristram H. Smith,et al.  Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. , 2015, The American journal of clinical nutrition.

[12]  K. Charlton,et al.  Fish Intake during Pregnancy and Foetal Neurodevelopment—A Systematic Review of the Evidence , 2014, Nutrients.

[13]  A. Sapkota,et al.  Maternal Mercury Exposure, Season of Conception and Adverse Birth Outcomes in an Urban Immigrant Community in Brooklyn, New York, U.S.A. , 2014, International journal of environmental research and public health.

[14]  T. O'hara,et al.  Prenatal exposure to methylmercury and LCPUFA in relation to birth weight. , 2014, Annals of epidemiology.

[15]  G. Wehby,et al.  A Comparative Analysis of Prenatal Care and Fetal Growth in Eight South American Countries , 2014, PloS one.

[16]  G. Lo Monte,et al.  Heavy metals and placental fetal-maternal barrier: a mini-review on the major concerns. , 2013, European review for medical and pharmacological sciences.

[17]  W. Cope,et al.  The Influence of Fish Length on Tissue Mercury Dynamics: Implications for Natural Resource Management and Human Health Risk , 2013, International journal of environmental research and public health.

[18]  J. Mol,et al.  Mercury Levels in Pristine and Gold Mining Impacted Aquatic Ecosystems of Suriname, South America , 2012, AMBIO.

[19]  P. Grandjean,et al.  Cohort studies of Faroese children concerning potential adverse health effects after the mothers’ exposure to marine contaminants during pregnancy , 2012, Acta Veterinaria Scandinavica.

[20]  P. Grandjean,et al.  Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption. , 2011, Nutrition reviews.

[21]  R. Slama,et al.  Prenatal mercury contamination: relationship with maternal seafood consumption during pregnancy and fetal growth in the ‘EDEN mother–child’ cohort , 2010, British Journal of Nutrition.

[22]  F. Ballester,et al.  Fish consumption during pregnancy, prenatal mercury exposure, and anthropometric measures at birth in a prospective mother-infant cohort study in Spain. , 2009, The American journal of clinical nutrition.

[23]  Robert L. Jones,et al.  Relation between Cord Blood Mercury Levels and Early Child Development in a World Trade Center Cohort , 2008, Environmental health perspectives.

[24]  M. Rahbar,et al.  Maternal Fish Consumption, Mercury Levels, and Risk of Preterm Delivery , 2006, Environmental health perspectives.

[25]  M. Storelli,et al.  Relationship between total mercury concentration and fish size in two pelagic fish species: implications for consumer health. , 2006, Journal of food protection.

[26]  G. Muckle,et al.  Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada) , 2004, Lipids.

[27]  Robert L. Jones,et al.  Hair Mercury Levels in U.S. Children and Women of Childbearing Age: Reference Range Data from NHANES 1999–2000 , 2004, Environmental health perspectives.

[28]  M. Kaminski,et al.  Fetal sex and indicated very preterm birth: results of the EPIPAGE study. , 2004, American journal of obstetrics and gynecology.

[29]  A. Baron,et al.  Fetal Gender Differences in Preterm Birth: Findings in a North American Cohort , 1992, American journal of perinatology.

[30]  S. Macdonald.  Suriname , 1983, Itinerario.