Vitamin K to Neonates: Peroral versus Intramuscular Administration

ABSTRACT. In a randomized study of 300 infants, the effect of 1 mg of peroral vitamin K given at birth was compared to the same dose given as an intramuscular injection. The combined activity of coagulation factor II + VII + X taken after 48 and before 72 hours after delivery served as the primary endpoint. Prothrombin (antigen) and PIVKA II (acarboxyprothrombin) were also measured. All infants were observed for events of bleeding until discharge from the hospital, normally on the fifth day. No significant differences between the groups in any of the biochemical markers were observed. The 95% confidence limits of the differences were very narrow for all factors. No cases of bleeding were observed. We conclude that administration of 1 mg peroral vitamin K is as efficient as intramuscular administration of the same dose in the prevention of classical hemorrhagic disease of the newborn.

[1]  L. Sann,et al.  Vitamin K in infancy , 2004, European Journal of Pediatrics.

[2]  R. von Kries,et al.  The use of vitamin K in the perinatal period. , 1989, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[3]  G. Schubiger,et al.  [Neonatal vitamin K prophylaxis and vitamin k deficiency hemorrhages in Switzerland 1986-1988]. , 1988, Schweizerische medizinische Wochenschrift.

[4]  M. La.  The use of vitamin K in the perinatal period. Fetus and Newborn Committee, Canadian Paediatric Society. , 1988, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[5]  U. Göbel,et al.  Acarboxyprothrombin activity after oral prophylactic vitamin K , 1987 .

[6]  R. von Kries,et al.  Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K. , 1987, Archives of disease in childhood.

[7]  J. Addiego,et al.  Use of oral vitamin K1 to prevent hemorrhagic disease of the newborn infant. , 1986, The Journal of pediatrics.

[8]  L. Sann,et al.  Serum vitamin K1 concentration and vitamin K-dependent clotting factor activity in maternal and fetal cord blood. , 1985, American journal of obstetrics and gynecology.

[9]  A. Mcninch,et al.  HAEMORRHAGIC DISEASE OF THE NEWBORN RETURNS , 1983, The Lancet.

[10]  P. Dunn.  VITAMIN K1 FOR ALL NEWBORN BABIES , 1982, The Lancet.

[11]  J. Birkbeck.  Vitamin K and the Newborn , 1978, The Lancet.

[12]  H. Takahama,et al.  [ON HEMORRHAGIC DISEASE OF THE NEWBORN]. , 1964, [Sanfujinka chiryo] Obstetrical and gynecological therapy.

[13]  K. Wefring.  Hemorrhage in the newborn and vitamin K prophylaxis. , 1962, The Journal of pediatrics.

[14]  J. Brooks-Gunn.  VITAMIN K DEFICIENCY IN NEWBORN INFANTS , 1960 .

[15]  H. Dam,et al.  The relation of vitamin K deficiency to hemorrhagic disease of the newborn. , 1952, Advances in pediatrics.

[16]  P. Owren,et al.  The control of dicumarol therapy and the quantitative determination of prothrombin and proconvertin. , 1951, Scandinavian journal of clinical and laboratory investigation.