Useful Brazilian plants listed in the field books of the French naturalist Auguste de Saint-Hilaire (1779-1853).

ETHNOPHARMACOLOGICAL RELEVANCE Information regarding the use of beneficial, native Brazilian plants was compiled by European naturalists in the 19th century. The French botanist Auguste de Saint-Hilaire (1779-1853) was one of the most important such naturalists; however, his manuscripts (field books) have not yet been studied, especially in the context of useful plants. AIM OF THE STUDY To present data documented by Saint-Hilaire in his field book regarding the use of native plants by the Brazilians. MATERIALS AND METHODS Data on useful plants were obtained from field books (six volumes) deposited in the Muséum national d' Histoire naturelle in Paris, France. The vernacular names of the plants, registered as "N.V." or "Nom Vulg." in the field book, were carefully searched. Traditional information about these plants was translated and organised using a computer. The botanical identification of each plant was determined and updated from the original descriptions and names cited in the field books by A. de Saint-Hilaire. Correlated pharmacological studies were obtained from PubMed. RESULTS A total of 283 useful plants were recorded from the field books and 165 (58.3%) could be identified to genus or species. Fifty-eight different traditional uses were registered for the identified plants; the most common were as purgatives and febrifuges. Other data recovered were related to edible fruits and plants with interesting sensorial characteristics. For the few species that have been subjected to laboratory studies, the efficacy of the recorded traditional uses was confirmed. CONCLUSION The data recorded by the French naturalist A. de Saint-Hilaire represent a rich, unexplored source of information regarding the traditional uses of Brazilian plants.

[1]  R. Y. Othman,et al.  The effect of Piper betle and Psidium guajava extracts on the cell-surface hydrophobicity of selected early settlers of dental plaque. , 2006, Journal of oral science.

[2]  P. Timon-David,et al.  Anthelmintic properties of Polygonum glabrum , 1987, The Journal of pharmacy and pharmacology.

[3]  K. Nakatsu,et al.  Periandrin I, a sweet triterpene-glycoside from periandra dulcis , 1983 .

[4]  V. Magrioti,et al.  Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases , 2010, Expert opinion on therapeutic patents.

[5]  M. G. Ferri,et al.  Viagem às nascentes do rio São Francisco , 1975 .

[6]  G. Fernandes,et al.  Influence of Brazilian herbal regulations on the use and conservation of native medicinal plants , 2010, Environmental monitoring and assessment.

[7]  David J Newman,et al.  Natural products as sources of new drugs over the 30 years from 1981 to 2010. , 2012, Journal of natural products.

[8]  C. Duque,et al.  Glycosidically bound flavor compounds of cape gooseberry (Physalis peruviana L.). , 2001, Journal of agricultural and food chemistry.

[9]  A. Kinghorn,et al.  Periandrin V, a further sweet triterpene glycoside from Periandra dulcis. , 1993, Phytochemistry.

[10]  Valdely Fereira Kinupp,et al.  Teores de proteína e minerais de espécies nativas, potenciais hortaliças e frutas , 2008 .

[11]  E. Aguiar,et al.  In vitro antimicrobial activity of Brazilian medicinal plant extracts against pathogenic microorganisms of interest to dentistry. , 2011, Planta medica.

[12]  D. Sawyer Climate change, biofuels and eco-social impacts in the Brazilian Amazon and Cerrado , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[13]  Priscilla E. Ávila,et al.  In vitro screening for antiplasmodial activity of isoquinoline alkaloids from Brazilian plant species. , 2004, Acta tropica.

[14]  C. Desmarchelier Neotropics and natural ingredients for pharmaceuticals: why isn't South American biodiversity on the crest of the wave? , 2010, Phytotherapy research : PTR.

[15]  P. W. Nel,et al.  The pathology of Cestrum laevigatum (Schlechtd.) poisoning in cattle. , 1991, The Onderstepoort journal of veterinary research.

[16]  J. Carvalho,et al.  Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw. , 2005, Journal of ethnopharmacology.

[17]  Maria Sebastiana Silva,et al.  Valor nutricional e características químicas e físicas de frutos de murici-passa (Byrsonima verbascifolia) , 2008 .

[18]  J. Valle,et al.  Timbós: ichthyotoxic plants used by Brazilian Indians. , 1984, Journal of ethnopharmacology.

[19]  Manoel Mendes Ramos Filho,et al.  CARACTERIZAÇÃO FÍSICO-QUÍMICA DO ARAÇÁ ( Psidium guineense SW.) E DO TARUMÃ ( Vitex cymosa Bert .) DO ESTADO DE MATO GROSSO DO SUL , 2004 .

[20]  H. D. Moya,et al.  Analysis of the polyphenols content in medicinal plants based on the reduction of Cu(II)/bicinchoninic complexes. , 2009, Journal of agricultural and food chemistry.

[21]  E. Abdel-Hameed,et al.  Antioxidant properties of methanolic extracts of the leaves of seven Egyptian Cassia species , 2010, Acta pharmaceutica.

[22]  F. Artal [Neurological syndromes associated with the ingestion of plants and fungi with a toxic component (II). Hallucinogenic fungi and plants, mycotoxins and medicinal herbs]. , 2003 .

[23]  R. Bussmann,et al.  Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies. , 2010, Journal of ethnopharmacology.

[24]  E. Pereira,et al.  Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities. , 1991, Memorias do Instituto Oswaldo Cruz.

[25]  C. Barros,et al.  Cestrum laevigatum poisoning in goats in southeastern Brazil. , 2000, Veterinary and human toxicology.

[26]  H. Bendaoud,et al.  Chemical composition and anticancer and antioxidant activities of Schinus molle L. and Schinus terebinthifolius Raddi berries essential oils. , 2010, Journal of food science.

[27]  C. G. Diniz,et al.  In vitro antioxidant potential of medicinal plant extracts and their activities against oral bacteria based on Brazilian folk medicine. , 2008, Archives of oral biology.

[28]  J. Vederas,et al.  Drug Discovery and Natural Products: End of an Era or an Endless Frontier? , 2009, Science.

[29]  R. Voeks Disturbance Pharmacopoeias: Medicine and Myth from the Humid Tropics , 2004, Annals of the Association of American Geographers.

[30]  S. Gambhir,et al.  Anti-inflammatory studies on Polygonum glabrum. , 1987, Journal of ethnopharmacology.

[31]  P. H. Ferri,et al.  Tannin composition of barbatimão species. , 2002, Fitoterapia.

[32]  E. Amaratunga,et al.  A randomised double-blind placebo-controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables. , 2011, The Ceylon medical journal.

[33]  Warren Dean With Broadax and Firebrand: The Destruction of the Brazilian Atlantic Forest , 1996 .

[34]  R. Monte-Mór,et al.  Traditional uses of American plant species from the 1st edition of Brazilian Official Pharmacopoeia. , 2009 .

[35]  S. Keita,et al.  Ethnobotanical survey and antibacterial activity of some plants used in Guinean traditional medicine. , 2007, Journal of ethnopharmacology.

[36]  P. Shanley,et al.  The Impacts of Forest Degradation on Medicinal Plant Use and Implications for Health Care in Eastern Amazonia , 2003 .

[37]  A. Begossi,et al.  Medicinal Plants in the Atlantic Forest (Brazil): Knowledge, Use, and Conservation , 2002 .

[38]  C. Fagg,et al.  European Naturalists and Medicinal Plants of Brazil , 2011 .

[39]  W. Kemmerling Toxicity of Palicourea marcgravii: Combined Effects of Fluoroacetate, N-methyltyramine and 2-Methyltetrahydro-β-carboline , 1996, Zeitschrift für Naturforschung C - A Journal of Biosciences.

[40]  H. Morita,et al.  Chemical and biological demonstration of the presence of monofluoroacetate in the leaves of Palicourea marcgravii St. Hil. , 1995, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[41]  M. Soares,et al.  Patenting bioactive molecules from biodiversity: the Brazilian experience , 2010, Expert opinion on therapeutic patents.

[42]  R. Chandra,et al.  Nutritional and Hypoglycemic Effect of Fruit Pulp of Annona squamosa in Normal Healthy and Alloxan-Induced Diabetic Rabbits , 2005, Annals of Nutrition and Metabolism.

[43]  J. Stehmann,et al.  Medicinal plants of Lavras Novas (Minas Gerais, Brazil) , 1995 .

[44]  A. Afolayan,et al.  Nutritional quality of some wild leafy vegetables in South Africa , 2009, International journal of food sciences and nutrition.

[45]  M. A. Kaplan,et al.  Chemical composition and antimicrobial activity of the essential oils of Ageratum fastigiatum (Asteraceae). , 2009 .

[46]  L. McKee,et al.  Selected nutritional and quality analyses of tomatillos (Physalis ixocarpa) , 1995, Plant foods for human nutrition.

[47]  A. Afolayan,et al.  Comparison of the nutritional value and biological activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[48]  R. Yunes,et al.  Evaluation of pharmacological activity of a crude hydroalcoholic extract from Jatropha elliptica , 1988 .

[49]  S. L. D. C. E. Silva,et al.  Ação anti-helmíntica de extratos brutos de Andira anthelmia (Vell.) Macbr. e Andira fraxinifolia Benth., em camundongos naturalmente infectados por Vampirolepis nana e Aspiculuris tetraptera , 2003 .

[50]  J. Carvalho,et al.  Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts. , 2005, Journal of ethnopharmacology.

[51]  Ilka Boaventura Leite Antropologia da viagem : escravos e libertos em Minas Gerais no século XIX , 1996 .

[52]  Takayuki Shibamoto,et al.  Chemical compositions and antioxidant/antimicrobial activities of various samples prepared from Schinus terebinthifolius leaves cultivated in Egypt. , 2009, Journal of agricultural and food chemistry.

[53]  A. Abdalla,et al.  Effect of some essential oils on in vitro methane emission , 2011, Archives of animal nutrition.

[54]  Auguste de Saint-Hilaire Viagem pelas províncias do Rio de Janeiro e Minas Gerais , 1938 .

[55]  M. Simmonds,et al.  Two novel assays for the detection of haemin-binding properties of antimalarials evaluated with compounds isolated from medicinal plants. , 2002, The Journal of antimicrobial chemotherapy.

[56]  G. Hammond,et al.  Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC. , 2006, Chemical & pharmaceutical bulletin.

[57]  Maria G L Brandão,et al.  Brazilian medicinal plants described by 19th century European naturalists and in the Official Pharmacopoeia. , 2008, Journal of ethnopharmacology.

[58]  R. R. Peters,et al.  Evaluation of antinociceptive activity of Casearia sylvestris and possible mechanism of action. , 2007, Journal of ethnopharmacology.

[59]  W. Vilegas,et al.  Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. , 2009, Journal of ethnopharmacology.

[60]  A. Amaral,et al.  Brazilian phytopharmaceuticals – evaluation against hospital bacteria , 2005, Phytotherapy research : PTR.

[61]  C. Fagg,et al.  Native foods from Brazilian biodiversity as a source of bioactive compounds , 2012 .

[62]  A. M. Giulietti,et al.  Atividade antibacteriana em alguns extratos de vegetais do semi-árido brasileiro , 2003 .

[63]  O. Franco,et al.  Identification of E. dysenterica laxative peptide: A novel strategy in the treatment of chronic constipation and irritable bowel syndrome , 2010, Peptides.

[64]  M. Gupta,et al.  Antibacterial activity of Urena lobata root. , 2001, Fitoterapia.

[65]  Valeria E Gazda,et al.  Toxicological evaluation of an ethanolic extract from Chiococca alba roots. , 2006, Journal of ethnopharmacology.

[66]  U. Albuquerque,et al.  Antiproliferative Activity, Antioxidant Capacity and Tannin Content in Plants of Semi-Arid Northeastern Brazil , 2010 .

[67]  M. A. Kaplan,et al.  Analgesic and Anti-inflammatory Properties of Essential Oil from Ageratum fastigiatum , 2009 .

[68]  D. Newman,et al.  Natural products as sources of new drugs over the last 25 years. , 2007, Journal of natural products.

[69]  W. B. Mors,et al.  Triaga Brasilica: renewed interest in a seventeenth-century panacea. , 1996, Toxicon : official journal of the International Society on Toxinology.

[70]  M. A. Murcia,et al.  Evaluation of the antioxidant properties of Mediterranean and tropical fruits compared with common food additives. , 2001, Journal of food protection.

[71]  N. Lopes,et al.  Contribution for the phytochemical studies of Ageratum fastigiatum , 2011 .

[72]  J. E. M. Ferrão,et al.  A aventura das plantas e os descobrimentos portugueses , 1992 .

[73]  M. Clerici,et al.  Nutritional bioactive compounds and technological aspects of minor fruits grown in Brazil , 2011 .

[74]  J. Stehmann,et al.  Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil. , 2003, Journal of ethnopharmacology.

[75]  S. Morais,et al.  Effect of six tropical tanniferous plant extracts on larval exsheathment of Haemonchus contortus. , 2011, Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria.

[76]  E. Schenkel,et al.  Pharmacological investigations on Achyrocline satureioides (LAM.) DC., Compositae. , 1988, Journal of ethnopharmacology.

[77]  J. Gittelsohn,et al.  Nutritional composition of commonly consumed traditional Apache foods in Arizona , 2008, International journal of food sciences and nutrition.