signaling pathway and CDK8 in HCT signaling pathway and CDK8 in HCT signaling pathway and CDK8 in HCT 116 and

Colorectal cancer is one of the leading causes of death worldwide. Wnt/ (cid:451) - catenin signalling pathway plays a central role in normal cellular responses, making it a potent target in cancer therapy. Study was taken to assess whether ellagic acid modulates Wnt/ (cid:451) - catenin pathway and CDK8 activity in colon cancer cells (HT 29 and HCT 116). Ellagic acid caused significant decrease in viability of cancer cells and markedly down-regulated the expression of CDK 8, (cid:451) - catenin, survivin, c-Myc and cyclin D1. siCDK8 transfection resulted in marked reduction in the expression of survivin, c-Myc and cyclin D1 as well. Considerable up-regulation in the expression of p-(cid:451) - catenin, axin1 and 2 following ellagic acid exposure were observed. Ellagic acid was able to effectively reduce cell viability and modulate expressions of Wnt/ (cid:451) - catenin signalling cascade proteins and down regulate the activity and expression of CDK8 in HT 29 and HCT 116 cells.

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