Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects

Abstract The objective of this study was to evaluate the effect of chronic airway inflammation on airway cough sensitivity and non‐specific bronchial responsiveness, and the relationship between them. The capsaicin cough threshold, defined as the lowest concentration of capsaicin causing five or more coughs, and non‐specific bronchial responsiveness, defined as the methacholine concentration causing a 20% fall in forced expiratory volume in 1 s (FEV1) (PC20‐FEV1)were measured in 18 asthmatic, 13 bronchitic (sinobronchial syndrome) and 28 healthy non‐atopic subjects. All subjects were non‐smoking men. The geometric mean values (μmol) of the cough threshold were 18.9 (GSEM 1.29), 8.69 (GSEM 1.29) and 27.6 (GSEM 1.31) in asthmatic, bronchitic and normal subjects, respectively. The value in bronchitic subjects was significantly lower (P“0.02) than that in normal subjects. The geometric mean value of PC20‐FEV1 in asthmatic subjects (0.48mg/ml (GSEM 1.38)) was significantly lower than that in bronchitic subjects (18.5mg/ml (GSEM 1.75)) (P“0.001). There was no correlation between cough threshold and PC20‐FEV1 values (correlation coefficient (r)= 0.155). These results indicate that cough sensitivity is potentiated by chronic airway inflammation in bronchitis but not in asthma, and suggest that cough sensitivity and bronchial responsiveness may be independently potentiated by different mechanisms resulting from chronic airway inflammation.

[1]  T Matsuda,et al.  Female gender as a determinant of cough threshold to inhaled capsaicin. , 1996, The European respiratory journal.

[2]  M. Fujimura,et al.  Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. , 1995, The European respiratory journal.

[3]  M. Fujimura,et al.  Log normal distribution of bronchial responsiveness to methacholine in normal young adults. , 1993, The Japanese journal of physiology.

[4]  L. Hansson,et al.  Capsaicin-induced cough in humans. , 1992, The American review of respiratory disease.

[5]  M. Fujimura,et al.  Effects of methacholine induced bronchoconstriction and procaterol induced bronchodilation on cough receptor sensitivity to inhaled capsaicin and tartaric acid. , 1992, Thorax.

[6]  P Wollmer,et al.  Regional sensitivity of human airways to capsaicin-induced cough. , 1992, The American review of respiratory disease.

[7]  M. Fujimura,et al.  Cough receptor sensitivity and bronchial responsiveness in normal and asthmatic subjects. , 1992, The European respiratory journal.

[8]  M. Fujimura,et al.  Cough threshold to inhaled tartaric acid and bronchial responsiveness to methacholine in patients with asthma and sino-bronchial syndrome. , 1992, Internal medicine.

[9]  J. Bousquet,et al.  Eosinophilic inflammation in asthma. , 1990, The New England journal of medicine.

[10]  M. Fujimura,et al.  Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma. , 1990, Chest.

[11]  M. Fujimura,et al.  Sex difference in the inhaled tartaric acid cough threshold in non-atopic healthy subjects. , 1990, Thorax.

[12]  R. Fuller,et al.  Physiology and treatment of cough. , 1990, Thorax.

[13]  M. Lebowitz,et al.  Smoking habit and bronchial reactivity in normal subjects. A population-based study. , 1989, The American review of respiratory disease.

[14]  J. Denburg,et al.  CHRONIC COUGH: EOSINOPHILIC BRONCHITIS WITHOUT ASTHMA , 1989, The Lancet.

[15]  K. Chung,et al.  Inflammatory mediators and asthma. , 1988, Pharmacological reviews.

[16]  J. Fleetham,et al.  Cigarette smoke inhalation patterns and bronchial reactivity. , 1988, Thorax.

[17]  F. Speizer,et al.  The relationship of nonspecific bronchial responsiveness to respiratory symptoms in a random population sample. , 1987, The American review of respiratory disease.

[18]  G. O'Connor,et al.  The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study. , 1987, The American review of respiratory disease.

[19]  J. Weiler,et al.  Airway responses to methacholine in asymptomatic nonatopic cigarette smokers. , 1987, Journal of applied physiology.

[20]  P. Burney,et al.  Descriptive epidemiology of bronchial reactivity in an adult population: results from a community study. , 1987, Thorax.

[21]  Phillips Yy,et al.  Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. , 1987, The American review of respiratory disease.

[22]  R. Townley,et al.  The effect of age on methacholine response. , 1985, The Journal of allergy and clinical immunology.

[23]  J. M. Codina,et al.  On the Hall effect in polycrystalline semiconductors , 1985 .

[24]  P. Barnes,et al.  Bronchoconstrictor response to inhaled capsaicin in humans. , 1985, Journal of applied physiology.

[25]  R W Fuller,et al.  Capsaicin inhalation in man and the effects of sodium cromoglycate , 1984, British journal of pharmacology.

[26]  P. Paré,et al.  Increased airway mucosal permeability of smokers. Relationship to airway reactivity. , 1984, The American review of respiratory disease.

[27]  J. Charpin.  Bronchial hyperreactivity. , 1984, Bulletin europeen de physiopathologie respiratoire.

[28]  D. Cockcroft,et al.  Bronchial response to inhaled histamine in asymptomatic young smokers. , 1983, European journal of respiratory diseases.

[29]  A. Saria,et al.  Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants , 1983, Nature.

[30]  S. Groth,et al.  Bronchial reactivity, smoking, and alpha1-antitrypsin. A population-based study of middle-aged men. , 1982, The American review of respiratory disease.

[31]  E. Juniper,et al.  Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation. , 1981, The Journal of allergy and clinical immunology.

[32]  S. Braman,et al.  Chronic cough as the sole presenting manifestation of bronchial asthma. , 1979, The New England journal of medicine.

[33]  H. Coleridge,et al.  Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs. , 1977, Respiration physiology.

[34]  D. Niewoehner,et al.  Pathologic changes in the peripheral airways of young cigarette smokers. , 1974, The New England journal of medicine.

[35]  J. Nadel,et al.  Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. , 1967, The Journal of clinical investigation.

[36]  Barach Al,et al.  The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents. , 1954 .

[37]  A. Barach,et al.  THE EXPERIMENTAL PRODUCTION OF COUGH IN HUMAN SUBJECTS INDUCED BY CITRIC ACID AEROSOLS. PRELIMINARY STUDIES ON THE EVALUATION OF ANTITUSSIVE AGENTS* , 1954, The American journal of the medical sciences.

[38]  E. Anglesio,et al.  [Sinobronchial syndrome]. , 1954, Minerva medica.