Renal regulation of calcium-phosphate metabolism in single- and twin pregnant goats.

The aim of this study was the clearance assessment of renal function in single- and twin-pregnant goats and a comparison of selected parameters associated with calcium-phosphate management in terms of litter size. Clearance studies were carried out on 16 pregnant Polish White Improved goats (8 single pregnancies and 8 twin pregnancies). It was demonstrated that the kidneys of pregnant goats regulate the calcium-phosphate balance to a great extent. In spite of observed differences in parameters of renal functions, plasma calcium and inorganic phosphorus concentrations were comparable with normal reference values in further weeks of pregnancy. Significant differences in renal function between single and twin pregnancies were not observed. Gut absorption and/or bone tissue metabolism seem important for the maintenance of appropriate calcium-phosphate status.

[1]  Ernst Pfeffer,et al.  Hormonal regulation of phosphate homeostasis in goats during transition to rumination , 2008, Journal of Comparative Physiology B.

[2]  K. Huber,et al.  Influence of dietary calcium and phosphorus supply on epithelial phosphate transport in preruminant goats , 2007, Journal of Comparative Physiology B.

[3]  F. Witter,et al.  Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. , 2003, The American journal of clinical nutrition.

[4]  A. Prentice.  Micronutrients and the bone mineral content of the mother, fetus and newborn. , 2003, The Journal of nutrition.

[5]  F. Meschy.  Eléments minéraux majeurs: données récentes chez les caprins , 2002 .

[6]  M. El-Sherif,et al.  Changes in some blood constituents of Barki ewes during pregnancy and lactation under semi arid conditions. , 2001, Small ruminant research : the journal of the International Goat Association.

[7]  Ahmed,et al.  Macromineral profile in the plasma of Nubian goats as affected by the physiological state. , 2000, Small ruminant research : the journal of the International Goat Association.

[8]  A. Prentice,et al.  Maternal calcium metabolism and bone mineral status. , 2000, The American journal of clinical nutrition.

[9]  B. Specker,et al.  Effects of calcium supplementation on calcium homeostasis and bone turnover in lactating women. , 1999, The Journal of clinical endocrinology and metabolism.

[10]  M. Rodehutscord,et al.  Body chemical composition and utilization of dietary energy by male Saanen kids fed either milk to satiation or solid complete feeds with two proportions of straw , 1998, The Journal of Agricultural Science.

[11]  C. Kovacs,et al.  Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. , 1997, Endocrine reviews.

[12]  H. Nasrat,et al.  Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study. , 1997, European journal of endocrinology.

[13]  J. Wladimiroff,et al.  Calcium metabolism, calcium supplementation and hypertensive disorders of pregnancy. , 1995, European journal of obstetrics, gynecology, and reproductive biology.

[14]  G. Quamme,et al.  Renal magnesium handling and its hormonal control. , 1994, Physiological reviews.

[15]  N. Roinel,et al.  Ca2+, Mg2+ and K+ transport in the cortical and medullary thick ascending limb of the rat nephron: influence of transepithelial voltage , 1993, Pflügers Archiv.

[16]  S. Husain,et al.  Mineral transport across the placenta. , 1992, Archives of disease in childhood.

[17]  S. C. Garner,et al.  Modulation of serum parathyroid hormone and ionized calcium concentrations during reproduction in rats fed a low calcium diet , 1988, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  C. Rodeck,et al.  Normal reference ranges for biochemical substances relating to renal, hepatic, and bone function in fetal and maternal plasma throughout pregnancy. , 1985, Journal of clinical pathology.

[19]  R. Reitz,et al.  Calcium, Magnesium, Phosphorus, and Parathyroid Hormone Interrelationships in Pregnancy and Newborn Infants , 1977, Obstetrics and gynecology.

[20]  A. Kasanen,et al.  Physiology of the kidney , 1974 .

[21]  D. Cole,et al.  Magnesium transport in the renal distal convoluted tubule. , 2001, Physiological reviews.

[22]  G. Breves,et al.  In vitro studies on calcium absorption from the gastrointestinal tract in␣small ruminants , 1997, Journal of Comparative Physiology B.

[23]  A. Wasilewska,et al.  The influence of the reproductive cycle on levels of some metabolism indices in ewes. , 1995, Archivum veterinarium Polonicum.

[24]  W. Skrzypczak,et al.  The effect of spironolactone (Aldactone) on electrolyte balance and renal functions of calves , 1994 .

[25]  E. Elias,et al.  Hypocalcaemia and serum levels of inorganic phosphorus, magnesium parathyroid and calcitonin hormones in the last month of pregnancy in Awassi fat-tail ewes. , 1990, Reproduction, nutrition, development.

[26]  L. Sullivan.  Physiology of the kidney , 1974 .