Is there a relation between extremely low frequency magnetic field exposure, inflammation and neurodegenerative diseases? A review of in vivo and in vitro experimental evidence.

[1]  K. Varani,et al.  Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E2 and cytokine release in human osteoarthritic synovial fibroblasts , 2012, Journal of cellular physiology.

[2]  Sahdeo Prasad,et al.  Age-associated chronic diseases require age-old medicine: role of chronic inflammation. , 2012, Preventive medicine.

[3]  R. Westerink,et al.  Organochlorine insecticides lindane and dieldrin and their binary mixture disturb calcium homeostasis in dopaminergic PC12 cells. , 2012, Environmental science & technology.

[4]  J. Cannon,et al.  The role of environmental exposures in neurodegeneration and neurodegenerative diseases. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[5]  C. Glass,et al.  Microglial cell origin and phenotypes in health and disease , 2011, Nature Reviews Immunology.

[6]  Hsin-Yi Lin,et al.  In vitro effects of low frequency electromagnetic fields on osteoblast proliferation and maturation in an inflammatory environment , 2011, Bioelectromagnetics.

[7]  P. Gómez-Ochoa,et al.  Pulsed electromagnetic fields decrease proinflammatory cytokine secretion (IL-1β and TNF-α) on human fibroblast-like cell culture , 2011, Rheumatology International.

[8]  C. Moussa,et al.  Inflammation in the early stages of neurodegenerative pathology , 2011, Journal of Neuroimmunology.

[9]  L. Ivashkiv.  Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states , 2011, European journal of immunology.

[10]  A. Kraft,et al.  Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity , 2011, International journal of environmental research and public health.

[11]  H. Adami,et al.  Epidemiology and etiology of Parkinson’s disease: a review of the evidence , 2011, European Journal of Epidemiology.

[12]  J. Cuppen,et al.  Extremely low frequency electromagnetic field exposure does not modulate toll-like receptor signaling in human peripheral blood mononuclear cells. , 2011, Cytokine.

[13]  P. Grammas,et al.  Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease , 2011, Journal of Neuroinflammation.

[14]  Anne Corbett,et al.  Alzheimer's disease , 2011, The Lancet.

[15]  D. Holtzman,et al.  Apolipoprotein E in Alzheimer's disease and other neurological disorders , 2011, The Lancet Neurology.

[16]  R. B. Damgaard,et al.  Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity. , 2011, Discovery medicine.

[17]  A. Pyle,et al.  Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. , 2011, Cell stem cell.

[18]  G. Fanó,et al.  Effects of Acute and Chronic Low Frequency Electromagnetic Field Exposure on PC12 Cells during Neuronal Differentiation , 2011, Cellular Physiology and Biochemistry.

[19]  Myrtill Simkó,et al.  Risks from accidental exposures to engineered nanoparticles and neurological health effects: A critical review , 2010, Particle and Fibre Toxicology.

[20]  D. Elías-Viñas,et al.  Effects of acute electromagnetic field exposure and movement restraint on antioxidant system in liver, heart, kidney and plasma of Wistar rats: A preliminary report , 2010, International journal of radiation biology.

[21]  B. Aksu,et al.  Extremely low‐frequency electromagnetic fields affect the immune response of monocyte‐derived macrophages to pathogens , 2010, Bioelectromagnetics.

[22]  N. Herrmann,et al.  A Meta-Analysis of Cytokines in Alzheimer's Disease , 2010, Biological Psychiatry.

[23]  Maria Feychting,et al.  Work-related exposure to extremely low-frequency magnetic fields and dementia: results from the population-based study of dementia in Swedish twins. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  M. Podda,et al.  Exposure to extremely low-frequency (50Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice , 2010, Experimental Neurology.

[25]  D. Kretzschmar,et al.  Alzheimer's Disease and tauopathy studies in flies and worms , 2010, Neurobiology of Disease.

[26]  M. Villarini,et al.  Brain DNA damage and 70-kDa heat shock protein expression in CD1 mice exposed to extremely low frequency magnetic fields , 2010, International journal of radiation biology.

[27]  T. Kalkan,et al.  Differentiation of K562 Cells Under ELF-EMF Applied at Different Time Courses , 2010, Electromagnetic biology and medicine.

[28]  C. T. Schembri,et al.  Transcranial Magnetic Stimulation for Migraine: A Safety Review , 2010, Headache.

[29]  K. H. Mild,et al.  Effects of 50-Hz magnetic field exposure on superoxide radical anion formation and HSP70 induction in human K562 cells , 2010, Radiation and environmental biophysics.

[30]  Z. Akan,et al.  Effect of ELF-EMF on Number of Apoptotic Cells; Correlation with Reactive Oxygen Species and HSP , 2010, Acta biologica Hungarica.

[31]  A. Gorąca,et al.  Effects of extremely low frequency magnetic field on the parameters of oxidative stress in heart. , 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[32]  B. Bianco,et al.  Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranes , 2010, Bioelectromagnetics.

[33]  Michael T. Heneka,et al.  Neuroglia in neurodegeneration , 2010, Brain Research Reviews.

[34]  Fred H. Gage,et al.  Mechanisms Underlying Inflammation in Neurodegeneration , 2010, Cell.

[35]  S. Akira,et al.  Pattern Recognition Receptors and Inflammation , 2010, Cell.

[36]  Brent D. Cameron,et al.  Inflammation, microglia, and alzheimer's disease , 2010, Neurobiology of Disease.

[37]  E. Ulukaya,et al.  Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain , 2010, Biological Trace Element Research.

[38]  M. Bizzarri,et al.  Modulation of redox status and calcium handling by extremely low frequency electromagnetic fields in C2C12 muscle cells: A real-time, single-cell approach. , 2010, Free radical biology & medicine.

[39]  M. Simkó,et al.  Exposure to ELF magnetic fields modulate redox related protein expression in mouse macrophages. , 2010, Toxicology letters.

[40]  T. Montine,et al.  Biomarkers of oxidative damage and inflammation in Alzheimer's disease. , 2010, Biomarkers in medicine.

[41]  D. Baker,et al.  Inflammation in neurodegenerative diseases , 2010, Immunology.

[42]  A. Patruno,et al.  Extremely low frequency electromagnetic fields modulate expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and cyclooxygenase‐2 in the human keratinocyte cell line HaCat: potential therapeutic effects in wound healing , 2010, The British journal of dermatology.

[43]  F. Gomes,et al.  PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion , 2009, Journal of the peripheral nervous system : JPNS.

[44]  Yuzo Takayama,et al.  Developmental effects of low frequency magnetic fields on P19-derived neuronal cells , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[45]  B. Imbimbo.  An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease , 2009, Expert opinion on investigational drugs.

[46]  M. Kivipelto,et al.  Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention , 2009, Dialogues in clinical neuroscience.

[47]  V. Caracciolo,et al.  Fifty hertz extremely low‐frequency magnetic field exposure elicits redox and trophic response in rat‐cortical neurons , 2009, Journal of cellular physiology.

[48]  M. Fini,et al.  Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts. , 2009, Osteoarthritis and cartilage.

[49]  Pietro L. Indovina,et al.  Cellular effects of extremely low frequency (ELF) electromagnetic fields , 2009, International journal of radiation biology.

[50]  H. Baik,et al.  Interleukin-4-induced oxidative stress via microglial NADPH oxidase contributes to the death of hippocampal neurons in vivo. , 2008, Current aging science.

[51]  N. Seyhan,et al.  Effects of various extremely low frequency magnetic fields on the free radical processes, natural antioxidant system and respiratory burst system activities in the heart and liver tissues. , 2008, Indian journal of biochemistry & biophysics.

[52]  S Di Luzio,et al.  Extremely low frequency electromagnetic field enhances human keratinocyte cell growth and decreases proinflammatory chemokine production , 2008, The British journal of dermatology.

[53]  J. Rothwell,et al.  Informing Dose-Finding Studies of Repetitive Transcranial Magnetic Stimulation to Enhance Motor Function: A Qualitative Systematic Review , 2008, Neurorehabilitation and neural repair.

[54]  Ana M. García,et al.  Occupational exposure to extremely low frequency electric and magnetic fields and Alzheimer disease: a meta-analysis. , 2008, International journal of epidemiology.

[55]  C. Grassi,et al.  Extremely low‐frequency electromagnetic fields promote in vitro neurogenesis via upregulation of Cav1‐channel activity , 2008, Journal of cellular physiology.

[56]  E. Rokita,et al.  Magnetic field anti-inflammatory effects in Crohn's disease depends upon viability and cytokine profile of the immune competent cells. , 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[57]  L. Tamer,et al.  Effects of long-term exposure of extremely low frequency magnetic field on oxidative/nitrosative stress in rat liver. , 2008, Journal of radiation research.

[58]  R. Puvanakrishnan,et al.  Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity. , 2007, Life sciences.

[59]  M. Dam,et al.  Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma , 2007, Neuroscience Letters.

[60]  Myrtill Simkó,et al.  Cell type specific redox status is responsible for diverse electromagnetic field effects. , 2007, Current medicinal chemistry.

[61]  M. Lardelli,et al.  Alzheimer disease: amyloidogenesis, the presenilins and animal models. , 2007, Biochimica et biophysica acta.

[62]  D. Eşsiz,et al.  Studies on antioxidant enzymes in mice exposed to pulsed electromagnetic fields. , 2007, Ecotoxicology and environmental safety.

[63]  S. Grimaldi,et al.  Extremely low frequency electromagnetic field exposure promotes differentiation of pituitary corticotrope‐derived AtT20 D16V cells , 2006, Bioelectromagnetics.

[64]  T. Gilmore.  Introduction to NF-κB: players, pathways, perspectives , 2006, Oncogene.

[65]  S. Mémet,et al.  NF-κB functions in the nervous system: From development to disease , 2006 .

[66]  Min-Chi Ku,et al.  Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. , 2006, Current pharmaceutical design.

[67]  A. Patruno,et al.  Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field. , 2006, Nitric oxide : biology and chemistry.

[68]  N. Kuster,et al.  Extremely low-frequency electromagnetic field (ELF-EMF) does not affect the expression of alpha3, alpha5 and alpha7 nicotinic receptor subunit genes in SH-SY5Y neuroblastoma cell line. , 2006, Toxicology letters.

[69]  Myrtill Simkó,et al.  Gene expression analysis of ELF-MF exposed human monocytes indicating the involvement of the alternative activation pathway. , 2006, Biochimica et biophysica acta.

[70]  N. Gregersen,et al.  Protein misfolding disorders: Pathogenesis and intervention , 2006, Journal of Inherited Metabolic Disease.

[71]  R. Ransohoff,et al.  The many roles of chemokines and chemokine receptors in inflammation. , 2006, The New England journal of medicine.

[72]  Z. Prolić,et al.  Effects of extremely low-frequency magnetic field in the brain of rats , 2006, Brain Research Bulletin.

[73]  S. Grimaldi,et al.  Extremely Low Frequency 7 Hz 100 µT Electromagnetic Radiation Promotes Differentiation in the Human Epithelial Cell Line HaCaT , 2006, Electromagnetic biology and medicine.

[74]  C. Mathers,et al.  Global prevalence of dementia: a Delphi consensus study , 2005, The Lancet.

[75]  M. Ciotti,et al.  Exposure to 50 Hz electromagnetic radiation promote early maturation and differentiation in newborn rat cerebellar granule neurons , 2005, Journal of cellular physiology.

[76]  G. Bodega,et al.  Acute and chronic effects of exposure to a 1-mT magnetic field on the cytoskeleton, stress proteins, and proliferation of astroglial cells in culture. , 2005, Environmental research.

[77]  C. Link.  Invertebrate models of Alzheimer's disease , 2005, Genes, brain, and behavior.

[78]  S. Rivest,et al.  Unraveling the Molecular Details Involved in the Intimate Link between the Immune and Neuroendocrine Systems , 2004, Experimental biology and medicine.

[79]  M. Simkó.  Induction of Cell Activation Processes by Low Frequency Electromagnetic Fields , 2004, TheScientificWorldJournal.

[80]  A. Sieroń,et al.  Alternating extremely low frequency magnetic field increases turnover of dopamine and serotonin in rat frontal cortex , 2004, Bioelectromagnetics.

[81]  Myrtill Simkó,et al.  Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: Possible immune cell activation , 2004, Journal of cellular biochemistry.

[82]  M. Karin,et al.  The two NF-κB activation pathways and their role in innate and adaptive immunity , 2004 .

[83]  M. Vila,et al.  NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[84]  P. Vignais.  The superoxide-generating NADPH oxidase: structural aspects and activation mechanism , 2002, Cellular and Molecular Life Sciences CMLS.

[85]  P. Brookes,et al.  Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. , 2002, Free radical biology & medicine.

[86]  W. Kisaalita,et al.  Effects of 60 Hz electromagnetic field exposure on APP695 transcription levels in differentiating human neuroblastoma cells. , 2002, Bioelectrochemistry.

[87]  A. Sieroń,et al.  Influence of alternating low frequency magnetic fields on reactivity of central dopamine receptors in neonatal 6‐hydroxydopamine treated rats , 2001, Bioelectromagnetics.

[88]  R. Egleton,et al.  Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression. , 2001, American journal of physiology. Heart and circulatory physiology.

[89]  Y. Nakamura,et al.  [Regulating factors for microglial activation]. , 2000, Seikagaku. The Journal of Japanese Biochemical Society.

[90]  D. Sorescu,et al.  NAD(P)H oxidase: role in cardiovascular biology and disease. , 2000, Circulation research.

[91]  R. G. Allen,et al.  Oxidative stress and gene regulation. , 2000, Free radical biology & medicine.

[92]  L. Eng,et al.  Effects of Pulsed Magnetic Stimulation on GFAP Levels in Cultured Astrocytes , 1999 .

[93]  M. Lenardo,et al.  The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives , 2010, Cell Research.

[94]  T. Zyss,et al.  Magnetic seizure therapy (MST)--a safer method for evoking seizure activity than current therapy with a confirmed antidepressant efficacy. , 2010, Neuro endocrinology letters.

[95]  Z. Prolić,et al.  Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain. , 2009, General physiology and biophysics.

[96]  A. Gorąca,et al.  The influence of low-frequency magnetic field on plasma antioxidant capacity and heart rate. , 2009, Wiadomosci lekarskie.

[97]  C. di Ilio,et al.  Chronic exposure to 50Hz magnetic fields causes a significant weakening of antioxidant defence systems in aged rat brain. , 2008, The international journal of biochemistry & cell biology.

[98]  C. di Ilio,et al.  Fifty hertz extremely low-frequency electromagnetic field causes changes in redox and differentiative status in neuroblastoma cells. , 2007, The international journal of biochemistry & cell biology.

[99]  L. V. Van Eldik,et al.  Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches. , 2007, International review of neurobiology.

[100]  N. Perkins,et al.  Integrating cell-signalling pathways with NF-κB and IKK function , 2007, Nature Reviews Molecular Cell Biology.

[101]  M. Röösli,et al.  Magnetic field exposure and neurodegenerative diseases – recent epidemiological studies , 2006, Sozial- und Präventivmedizin.

[102]  Possible effects of Electromagnetic Fields (EMF) on Human Health , 2006 .

[103]  S. Bondy,et al.  Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer's disease. , 2003, Journal of Alzheimer's disease : JAD.

[104]  M. Vila,et al.  Series Introduction: Neurodegeneration: What is it and where are we? , 2003 .

[105]  K. Jellinger.  General aspects of neurodegeneration. , 2003, Journal of neural transmission. Supplementum.

[106]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[107]  W. Dröge.  Free radicals in the physiological control of cell function. , 2002, Physiological reviews.

[108]  A. Puga,et al.  Regulation of gene expression by reactive oxygen. , 1999, Annual review of pharmacology and toxicology.

[109]  M. Egger,et al.  American Journal of Epidemiology Original Contribution Residence near Power Lines and Mortality from Neurodegenerative Diseases: Longitudinal Study of the Swiss Population , 2022 .

[110]  F. Panza,et al.  Frontiers in Aging Neuroscience Aging Neuroscience Review Article Brain Inflammation in Alzheimer's Disease , 2022 .