practice guideline

MELD)-VDBP were significantly higher than those of MELD ( P = 0.0384) only in the case of cirrhotic HBV-ACLF patients. Similar results were validated using an external multicenter HBV-ACLF cohort. By longitudinal observation, the VDBP levels gradually increased in survivors ( P =0.026) and gradually decreased in non-survivors ( P <0.001). Additionally, the VDBP levels were found to be significantly decreased in the deterioration group ( P =0.012) and tended to be decreased in the fluctuation group ( P =0.055). In contrast, they showed a significant increase in the improvement group ( P =0.036). Conclusions: The VDBP was a promising prognostic biomarker for HBV-ACLF. Sequential measurement of circulating VDBP shows value for the monitoring of ACLF progression. (Clin Mol Hepatol 2022;28:912-925)

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