Neuroendocrine response to fenfluramine in patients with idiopathic pain syndromes

In chronic pain patients, a long series of studies indicate disturbances in the serotoninergic systems as one important pathogenetic factor. One way of studying the function of the serotoninergic system would be to study the neuroendocrine responses to serotoninergic agonists. In the present study, twelve healthy volunteers and 17 chronic pain patients were given fenfluramine, 60 mg, at 8 a.m. Serum Cortisol and serum prolactin were measured at 8 a.m., 9 a.m., 10 a.m., 11 a.m. and at noon. The symptomatology was at the same time determined using visual analogue scales (VAS). Fenfluramine, a drug that releases intraneuronal serotonin and blocks the reuptake of serotonin, seems to have a stimulatory effect on the release of Cortisol and prolactin. As concerns serum Cortisol, the chronic pain patients had significantly lower values at 8 a.m. than the healthy volunteers. From 8 a.m. to 10 a.m. the values increased in the chronic pain patients but decreased in the healthy volunteers. The difference between the...

[1]  Andrew H. Miller,et al.  The neuroendocrine response to fenfluramine in depressives and normal controls , 1988, Biological Psychiatry.

[2]  L. Knorring.  Affect and pain: Neurochemical mediators and therapeutic approaches , 1987, PAIN.

[3]  L. Knorring,et al.  5-HIAA and HVA in CSF in patients with idiopathic pain disorders , 1987, Biological Psychiatry.

[4]  R. Kahn,et al.  Hormonal probes of central serotonergic activity: Do they really exist? , 1987, Biological Psychiatry.

[5]  N. Rowland,et al.  Neurobiology of an anorectic drug: Fenfluramine , 1986, Progress in Neurobiology.

[6]  G. Millinger.  Neutral amino acid therapy for the management of chronic pain. , 1986, Cranio : the journal of craniomandibular practice.

[7]  D. Murphy,et al.  Use of serotonergic agents in the clinical assessment of central serotonin function. , 1986, The Journal of clinical psychiatry.

[8]  N. Ward,et al.  Differential effects of fenfluramine and dextroamphetamine on acute and chronic pain , 1984, PAIN.

[9]  D. Murphy,et al.  Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. , 1984, Life sciences.

[10]  W. Jb,et al.  idiopathic pain disorder: a critique of pain-prone disorder and a proposal for a revision of the DSM-III category psychogenic pain disorder. , 1982 .

[11]  F. Johansson,et al.  A double-blind controlled study of a serotonin uptake inhibitor (Zimelidine) versus placebo in chronic pain patients , 1979, Pain.

[12]  H. Fields,et al.  Endogenous pain control mechanisms: Review and hypothesis , 1978, Annals of neurology.

[13]  R. Messing,et al.  Serotonin-containing neurons: their possible role in pain and analgesia , 1977, Pain.

[14]  R. Sternbach.  Pain Patients: Traits and Treatments , 1974 .

[15]  L. von Knorring,et al.  A double-blind randomized study of clomipramine versus maprotiline in patients with idiopathic pain syndromes. , 1988, Neuropsychobiology.

[16]  L. Knorring,et al.  Biological markers in chronic pain syndromes , 1988 .

[17]  L. Knorring.  The experience of pain in patients with depressive disorders : a clinical and experimental study , 1975 .

[18]  L. Fisher,et al.  Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake. , 1975, Psychopharmacology communications.