Field boundary problems in controlled release pharmaceuticals. II: swelling-controlled release

A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.

[1]  Nicholas A. Peppas,et al.  Modelling of drug diffusion through swellable polymeric systems , 1980 .

[2]  H. Hopfenberg,et al.  Swelling‐controlled, constant rate delivery systems , 1978 .

[3]  Ping I. Lee.  Diffusional release of a solute from a polymeric matrix — approximate analytical solutions , 1980 .

[4]  Donald R Paul,et al.  Diffusional release of a solute from a polymer matrix , 1976 .

[5]  Thomas Erneux,et al.  Free boundary problems in controlled release pharmaceuticals. I: diffusion in glassy polymers , 1988 .

[6]  W I Higuchi,et al.  Release of medroxyprogesterone acetate from a silicone polymer. , 1970, Journal of pharmaceutical sciences.

[7]  T. Higuchi,et al.  Rate of release of medicaments from ointment bases containing drugs in suspension. , 1961, Journal of pharmaceutical sciences.

[8]  Y. Chien,et al.  Controlled drug release from polymeric delivery devices. II. Differentiation between partition-controlled and matrix-controlled drug release mechanisms. , 1974, Journal of pharmaceutical sciences.

[9]  N. Peppas,et al.  The swelling interface number as a criterion for prediction of diffusional solute release mechanisms in swellable polymers , 1983 .

[10]  T. Higuchi.  MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. , 1963, Journal of pharmaceutical sciences.

[11]  Giulio C. Sarti,et al.  A class of mathematical models for sorption of swelling solvents in glassy polymers , 1978 .