ROLE OF RESISTANCE EXERCISE IN CONTROLLING INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND IT’S ASSOCIATION WITH METABOLIC DISEASE PREVENTION

Based on data Riset Kesehatan Dasar (Riskesdas) in 2007, the people who had no or low physical activity reached 48.2 %. This condition contributes to increase number of metabolic disease cases such as: hypertension, heart disease, stroke and diabetes mellitus. Optimizing training approach especially aerobic type helps to counter metabolic diseases. Unfortunately, benefits of resistance training (RT) is less understood. RT improves muscle strength, induce muscle hypertrophy, improvement of local muscular performance, and also help to strenghtening body balance and coordination. There is interplay between training and hormone in muscle adaptation during resistance training. Hormone plays an important role in the regeneration of muscle after resistance training. The changes of hormone level cause hypertrophy. Regeneration and muscle hypertrophy are mediated by activation, proliferation and differentiation of satellite cells. It is regulated by mitotic and myogenic activity, namely insulin-like growth factor-1 (IGF-1), which serves as a paracrine or autocrine. Better understanding of homeostasis hormone during training in skeletal muscle and its ultimate purpose to counter metabolic disease will lead us to better treatment approach for the patient.