Improvements in Door-to-Balloon Time in the United States, 2005 to 2010

Background— Registry studies have suggested improvements in door-to-balloon times, but a national assessment of the trends in door-to-balloon times is lacking. Moreover, we do not know whether improvements in door-to-balloon times were shared equally among patient and hospital groups. Methods and Results— This analysis includes all patients reported by hospitals to the Centers for Medicare & Medicaid Services for inclusion in the time to percutaneous coronary intervention (acute myocardial infarction-8) inpatient measure from January 1, 2005, through September 30, 2010. For each calendar year, we summarized the characteristics of patients reported for the measure, including the number and percentage in each group, the median time to primary percutaneous coronary intervention, and the percentage with time to primary percutaneous coronary intervention within 75 minutes and within 90 minutes. Door-to-balloon time declined from a median of 96 minutes in the year ending December 31, 2005, to a median of 64 minutes in the 3 quarters ending September 30, 2010. There were corresponding increases in the percentage of patients who had times <90 minutes (44.2% to 91.4%) and <75 minutes (27.3% to 70.4%). The declines in median times were greatest among groups that had the highest median times during the first period: patients >75 years of age (median decline, 38 minutes), women (35 minutes), and blacks (42 minutes). Conclusion— National progress has been achieved in the timeliness of treatment of patients with ST-segment–elevation myocardial infarction who undergo primary percutaneous coronary intervention.

[1]  H. Krumholz,et al.  Time-to-reperfusion in patients undergoing interhospital transfer for primary percutaneous coronary intervention in the U.S: an analysis of 2005 and 2006 data from the National Cardiovascular Data Registry. , 2008, Journal of the American College of Cardiology.

[2]  Harlan M Krumholz,et al.  What is the experience of national quality campaigns? Views from the field. , 2010, Health services research.

[3]  Harlan M Krumholz,et al.  Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. , 2006, Journal of the American College of Cardiology.

[4]  Barbara T. Unger,et al.  Design of a standardized system for transfer of patients with ST-elevation myocardial infarction for percutaneous coronary intervention. , 2005, American heart journal.

[5]  Roger D. White,et al.  Using prehospital electrocardiograms to improve door-to-balloon time for transferred patients with ST-elevation myocardial infarction: a case of extreme performance. , 2010, Circulation. Cardiovascular quality and outcomes.

[6]  K. Anstrom,et al.  Implementation of a statewide system for coronary reperfusion for ST-segment elevation myocardial infarction. , 2007, JAMA.

[7]  Jerod M Loeb,et al.  Quality of Care in U . S . Hospitals as Reflected by Standardized Measures , 2002 – 2004 , 2005 .

[8]  E. Antman,et al.  Primary percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: does the choice of fibrinolytic agent impact on the importance of time-to-treatment? , 2004, The American journal of cardiology.

[9]  Harlan M Krumholz,et al.  Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 Analysis , 2005, Circulation.

[10]  Harlan M Krumholz,et al.  The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction, 2000-2002: findings from the National Registry of Myocardial Infarction-4. , 2006, Journal of the American College of Cardiology.

[11]  Ingrid M. Nembhard,et al.  National efforts to improve door-to-balloon time results from the Door-to-Balloon Alliance. , 2009, Journal of the American College of Cardiology.

[12]  Harlan M Krumholz,et al.  Summary of evidence regarding hospital strategies to reduce door-to-balloon times for patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. , 2007, Critical pathways in cardiology.

[13]  Harlan M. Krumholz,et al.  Achieving Rapid Door-To-Balloon Times: How Top Hospitals Improve Complex Clinical Systems , 2006, Circulation.

[14]  C. Cannon,et al.  Door-to-balloon times in hospitals within the get-with-the-guidelines registry after initiation of the door-to-balloon (D2B) Alliance. , 2009, The American journal of cardiology.

[15]  G. Lamas,et al.  ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients wi , 2004, Journal of the American College of Cardiology.

[16]  H. Krumholz,et al.  A campaign to improve the timeliness of primary percutaneous coronary intervention: Door-to-Balloon: An Alliance for Quality. , 2008, JACC. Cardiovascular interventions.

[17]  Harlan M Krumholz,et al.  Strategies for reducing the door-to-balloon time in acute myocardial infarction. , 2006, The New England journal of medicine.

[18]  Peter Moyer,et al.  Recommendation to Develop Strategies to Increase the Number of ST-Segment–Elevation Myocardial Infarction Patients With Timely Access to Primary Percutaneous Coronary Intervention , 2006, Circulation.

[19]  Christopher E. Buller,et al.  2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines , 2008, Circulation.

[20]  M. Bell,et al.  Sustaining Improvement in Door-to-Balloon Time Over 4 Years: The Mayo Clinic ST-Elevation Myocardial Infarction Protocol , 2009, Circulation. Cardiovascular quality and outcomes.

[21]  Harlan M Krumholz,et al.  Association of door-to-balloon time and mortality in patients > or =65 years with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. , 2009, The American journal of cardiology.

[22]  H. Krumholz,et al.  Hospital improvement in time to reperfusion in patients with acute myocardial infarction, 1999 to 2002. , 2006, Journal of the American College of Cardiology.

[23]  Harlan M Krumholz,et al.  Door-to-drug and door-to-balloon times: where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI). , 2006, American heart journal.

[24]  H. Krumholz,et al.  Association of door-in to door-out time with reperfusion delays and outcomes among patients transferred for primary percutaneous coronary intervention. , 2011, JAMA.

[25]  J. Lowe,et al.  The Wavefront Phenomenon of Ischemic Cell Death: 1. Myocardial Infarct Size vs Duration of Coronary Occlusion in Dogs , 1977, Circulation.

[26]  Harlan M. Krumholz,et al.  ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for ST-Elevation and Non-ST-Eleva , 2006, Journal of the American College of Cardiology.

[27]  G. Lamas,et al.  Focused Update of the ACC / AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction , 2007 .

[28]  Denise H. Daudelin,et al.  Improving Use of Prehospital 12-Lead ECG for Early Identification and Treatment of Acute Coronary Syndrome and ST-Elevation Myocardial Infarction , 2010, Circulation. Cardiovascular quality and outcomes.