Mitochondrial C1QBP is essential for T cell antitumor function by maintaining mitochondrial plasticity and metabolic fitness

[1]  Junnian Zheng,et al.  Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune function , 2022, Cancer science.

[2]  F. Liu,et al.  Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming , 2021, Science advances.

[3]  Guangyong Peng,et al.  Mitochondria orchestrate T cell fate and function , 2021, Nature Immunology.

[4]  G. Coukos,et al.  Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion , 2020, Nature Immunology.

[5]  Junnian Zheng,et al.  Manipulation of Mitochondrial Plasticity Changes the Metabolic Competition Between “Foe” and “Friend” During Tumor Malignant Transformation , 2020, Frontiers in Oncology.

[6]  O. Kepp,et al.  Mitophagy, Mitochondrial Homeostasis, and Cell Fate , 2020, Frontiers in Cell and Developmental Biology.

[7]  Howard Y. Chang,et al.  Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen , 2020, Nature Immunology.

[8]  Lucia-Doina Popov.  Mitochondrial biogenesis: An update , 2020, Journal of cellular and molecular medicine.

[9]  Meijia Yang,et al.  B7-H3-Targeted CAR-T Cells Exhibit Potent Antitumor Effects on Hematologic and Solid Tumors , 2020, Molecular therapy oncolytics.

[10]  S. Berger,et al.  TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision. , 2019, Immunity.

[11]  Meijia Yang,et al.  B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma , 2019, Molecular therapy oncolytics.

[12]  P. Moraes-Vieira,et al.  Mitochondria as central hub of the immune system , 2019, Redox biology.

[13]  J. Yeh,et al.  Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells. , 2019, Cancer cell.

[14]  Daniel E. Speiser,et al.  Intratumoral Tcf1+PD‐1+CD8+ T Cells with Stem‐like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy , 2019, Immunity.

[15]  T. Uchiumi,et al.  Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation. , 2018, Cell reports.

[16]  E. Pearce,et al.  Unraveling the Complex Interplay Between T Cell Metabolism and Function. , 2018, Annual review of immunology.

[17]  E. Pearce,et al.  Immunometabolism in 2017: Driving immunity: all roads lead to metabolism , 2017, Nature Reviews Immunology.

[18]  Erika L. Pearce,et al.  Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function. , 2018, Trends in immunology.

[19]  T. Uchiumi,et al.  Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration , 2017, Scientific Reports.

[20]  W. Rathmell,et al.  Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. , 2017, JCI insight.

[21]  D. Dimitrov,et al.  Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. , 2017, Cancer cell.

[22]  G. Voeltz,et al.  Multiple Dynamin family members collaborate to drive mitochondrial division , 2016, Nature.

[23]  E. Wherry,et al.  Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. , 2016, Immunity.

[24]  Simon C Watkins,et al.  The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. , 2016, Immunity.

[25]  Michael Loran Dustin,et al.  Mitochondrial fusion fuels T cell memory , 2016, Cell Research.

[26]  Matheus C. Bürger,et al.  Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy , 2016, Nature.

[27]  O. Kretz,et al.  Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming , 2016, Cell.

[28]  T. Langer,et al.  OPA1 processing in cell death and disease – the long and short of it , 2016, Journal of Cell Science.

[29]  Prashant Mishra,et al.  Metabolic regulation of mitochondrial dynamics , 2016, The Journal of cell biology.

[30]  T. Wai,et al.  Mitochondrial Dynamics and Metabolic Regulation , 2016, Trends in Endocrinology & Metabolism.

[31]  Y. Okazaki,et al.  A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies , 2016, PLoS genetics.

[32]  J. Lippincott-Schwartz,et al.  Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics. , 2015, Developmental cell.

[33]  S. Sleijfer,et al.  Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells , 2014, British Journal of Cancer.

[34]  Prashant Mishra,et al.  Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. , 2014, Cell metabolism.

[35]  Sara Cipolat,et al.  Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency , 2013, Cell.

[36]  A. M. van der Bliek,et al.  Mitochondrial Fission, Fusion, and Stress , 2012, Science.

[37]  T. Uchiumi,et al.  p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability , 2012, Nucleic acids research.

[38]  G. V. D. van der Windt,et al.  Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. , 2012, Immunity.

[39]  K. Chung,et al.  p32 regulates mitochondrial morphology and dynamics through parkin , 2011, Neuroscience.

[40]  D. Hardie.  AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. , 2011, Genes & development.

[41]  J. Lippincott-Schwartz,et al.  Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation , 2011, Proceedings of the National Academy of Sciences.

[42]  J. Auwerx,et al.  Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. , 2011, The American journal of clinical nutrition.

[43]  K. Kuroiwa,et al.  Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate‐specific antigen relapse time after radical prostatectomy , 2011, Cancer science.

[44]  O. Shirihai,et al.  Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis , 2009, Diabetes.

[45]  David G. Nicholls,et al.  Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure , 2009, Journal of neurochemistry.

[46]  P. Puigserver,et al.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009, Nature.

[47]  David A Ferrick,et al.  Advances in measuring cellular bioenergetics using extracellular flux. , 2008, Drug discovery today.

[48]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[49]  L. Scorrano,et al.  OPA1 requires mitofusin 1 to promote mitochondrial fusion. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[50]  Erik E. Griffin,et al.  Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development , 2003, The Journal of cell biology.

[51]  D. Kang,et al.  p32 Protein, a Splicing Factor 2-associated Protein, Is Localized in Mitochondrial Matrix and Is Functionally Important in Maintaining Oxidative Phosphorylation* , 1997, The Journal of Biological Chemistry.