MARKERS OF SYSTEMIC INFLAMMATION AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract. Numerous studies have shown the impact of systemic inflammation on the formation of endothelial dysfunction in patients with COPD . In this review it is shown that cytokines, intercellular adhesion molecules, acute phase proteins , endoth elin-1, nitric oxide take an active part in this process. To assess endothelial damage are used the definition of arterial rigidity , as well as the level of expression of cytokines and cell adhesion molecules . Key words: COPD , endothelial dysfunction, systemic inflammation , arterial rigidity. Хроническая обструктивная болезнь легких (ХОБЛ) – это заболевание с прогрессирующим нарушением функции внешнего дыхания, которое связано с воспалительной реак-цией легочной ткани на раздражение различными патоген-ными агентами и газами [28]. По современным представлениям ХОБЛ характеризуется хроническим ограничением скорости воздушного потока, разнообразными патологическими изменениями в легких, существенными внелегочными проявлениями и серьезными сопутствующими заболеваниями, которые могут дополни-тельно отягощать течение ХОБЛ у отдельных пациентов и ухудшать прогноз. [18, 34,43]. Большие надежды в медицинской диагностике ХОБЛ связывают с анализом уже известных, и поиском новых биомаркеров, которые позволят оценить различные аспекты ХОБЛ, такие как патогенез, тяжесть, прогноз болезни и ответ на терапию [18, 23].

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