Integrated microfluidic array chip and LED photometer system for sulfur dioxide and methanol concentration detection

Abstract An integrated platform comprising a PMMA (Polymethyl-Methacrylate) microfluidic array chip and a LED photometer system is proposed for the concentration detection of sulfur dioxide (SO 2 ) and methanol (CH 4 O). In the proposed device, the sample and reagent are injected into six open chambers on the microfluidic chip and are mixed via a vortex stirring effect. Following the mixing process, a colorimetric reaction is induced between the sample and the reagent by means of a microhotplate positioned beneath the microfluidic chip array. The microfluidic chip is then transferred to a LED photometer system for detection purposes. The experimental results show that correlation coefficients of R 2  = 0.9915 and R 2  = 0.9941 are obtained when plotting the photometer output voltage against the SO 2 and CH 4 O concentrations of control samples with known concentrations ranging from 50 to 500 ppm. The real-world applicability of the proposed experimental platform is demonstrated by measuring the SO 2 concentration in two commercial Chinese herbs and the CH 4 O concentration in two commercial wines. It is shown that the concentration measurements obtained using the proposed system deviate by no more than 9% from those obtained using standard macroscale methods. Overall, the results presented in this study show that the proposed integrated microfluidic platform provides a compact and reliable tool for SO 2 and CH 4 O concentration measurement purposes.

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