论文信息 - Standardization of antiphospholipid antibodies ELISA

Standardization of antiphospholipid antibodies ELISA

抗リン脂質抗体症候群(APS)は,血液中に抗リン脂質抗体が出現し,動脈および静脈の血栓塞栓症(脳梗塞,肺梗塞,深部静脈血栓症など),不育症や習慣流産などの妊娠合併症を引き起こす自己免疫疾患である.APSの診断は「臨床所見」と「検査所見」の双方からなされ,2006年に改訂された抗リン脂質抗体症候群分類基準案(“Sapporo Criteria” Sydney改訂版) (表 1)に記載されている「検査所見」としては,1 国際血栓止血学会の診断ガイドラインに基づいた方法でループスアンチコアグラント(LA)が陽性,2 IgG型または IgM型の抗カルジオリピン抗体(aCL) が陽性:健常人の 99パーセンタイル以上または 40 単位以上,3 IgG型または IgM型の抗 β2-グリコプ ELISAによる抗リン脂質抗体価測定の標準化に向けて本木由香里,野島順三,吉田美香,關谷暁子,原和冴, 森下英理子,家子正裕

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